Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 11, 2007, Pages 5058-5067

  Zode, Gulab S ^a,c   Clark, Abbot F ^a,b   Wordinger, Robert J ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b ALCON RESEARCH LTD   (United States)

^c UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; SMAD PROTEIN; SMAD1 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; BONE MORPHOGENETIC PROTEIN;

ARTICLE; ASTROCYTE; CELL ISOLATION; CELL LYSATE; CELL SECRETION; CELL TYPE; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; LAMINA CRIBROSA CELL; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; AGED; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; MIDDLE AGED; OPTIC DISK; PHOSPHORYLATION; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; ASTROCYTES; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOPRECIPITATION; MIDDLE AGED; OPTIC DISK; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 38449087480     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0127     Document Type: Article

References (41)

1. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmology. 1996;80:389-393.
2. Rohen JW. Why is intraocular pressure elevated in chronic simple glaucoma? anatomical considerations. Ophthalmology. 1983;90:758-765.
3. Rohen JW, Lutjen-Drecoll E, Flugel C, Meyer M, Grierson I. Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG). Exp Eye Res. 1993;56:683-692.
4. Grierson I, Calthorpe CM. Characteristics of meshwork cells and age changes in the outflow system of the eye: their relevance to primary open angle glaucoma. In: Mills KB, ed. Glaucoma: Proceedings of the Fourth International Symposium of the Northern Eye Institute. New York: Pergamon; 1989:12-31.
5. Anderson DR. Ultrastructure of human and monkey lamina cribrosa and optic nerve head. Arch Ophthalmol. 1969;82:800-814.
6. Hernandez M, Gong H. Extracellular matrix of the trabecular meshwork and optic nerve head. In: Ritch R, Shields MB, Krupin T, eds. The Glaucomas. Mosby: St. Louis; 1996:213-249.
7. Hernandez MR, Andrzejewska WM, Neufeld AH. Changes in the extracellular matrix of the human optic nerve head in primary open-angle glaucoma. Am J Ophthalmol. 1990;109:180-188.
8. Hernandez MR, Pena JD. The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol. 1997;115:389-395.
9. Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, Cordeiro MF. Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest Ophthalmol Vis Sci. 2005;46:175-182.
10. Quigley HA. Neuronal death in glaucoma. Prog Retin Eye Res. 1999;18:39-57.
11. Quigley HA, Hohman RM, Addicks EM, Massof RW, Green WR. Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma. Am J Ophthalmol. 1983;95:673-691.
12. Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, Zack DJ. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci. 1995;36:774-786.
13. Morrison JC, Dorman-Pease ME, Dunkelberger GR, Quigley HA. Optic nerve head extracellular matrix in primary optic atrophy and experimental glaucoma. Arch Ophthalmol. 1990;108:1020-1024.
14. Hernandez MR, Igoe F, Neufeld AH. Cell culture of the human lamina cribrosa. Invest Ophthalmol Vis Sci. 1988;29:78-89.
15. Hernandez MR. The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 2000;19:297-321.
16. Johnson EC, Morrison JC, Farrell S, Deppmeier L, Moore CG, McGinty MR. The effect of chronically elevated intraocular pressure on the rat optic nerve head extracellular matrix. Exp Eye Res. 1996;62:663-674.
17. Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF. Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. Mol Vis. 2002;8:241-250.
18. von Bubnoff A, Cho KW. Intracellular BMP signaling regulation in vertebrates: pathway or network? Dev Biol. 2001;239:1-14.
19. Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 1996;10:1580-1594.
20. Attisano L, Tuen Lee-Hoeflich S. The Smads. Genome Biol. 2001;2:REVIEWS3010.
21. Balemans W, Van Hul W. Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev Biol. 2002;250:231-250.
22. Yamashita H, Ten Dijke P, Heldin CH, Miyazono K. Bone morphogenetic protein receptors. Bone. 1996;19:569-574.
23. Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science. 1988;242:1528-1534.
24. Roberts AB, Heine UI, Flanders KC, Sporn MB. Transforming growth factor-beta: major role in regulation of extracellular matrix. Ann NY Acad Sci. 1990;580:225-232.
25. Nohe A, Keating E, Knaus P, Petersen NO. Signal transduction of bone morphogenetic protein receptors. Cell Signal. 2004;16:291-299.
26. Chang B, Smith RS, Peters M, et al. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genet. 2001;2:18.
27. Wang S, Hirschberg R. Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. J Biol Chem. 2004;279:23200-23206.
28. Wordinger RJ, Fleenor DL, Hellberg PE, et al. Effects of TGF-β2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Invest Ophthalmol Vis Sci. 2007;48:1191-1200.
29. Lambert W, Agarwal R, Howe W, Clark AF, Wordinger RJ. Neurotrophin and neurotrophin receptor expression by cells of the human lamina cribrosa. Invest Ophthalmol Vis Sci. 2001;42:2315-2323.
30. Lambert WS, Clark AF, Wordinger RJ. Neurotrophin and trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation. BMC Neurosci. 2004;5:51.
31. Souchelnytskyi S, Nakayama T, Nakao A, et al. Physical and functional interaction of murine and xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors. J Biol Chem. 1998;273:25364-25370.
32. Zhao J, Crowe DL, Castillo C, Wuenschell C, Chai Y, Warburton D. Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis. Mech Dev. 2000;93:71-81.
33. Nakao A, Afrakhte M, Moren A, et al. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature. 1997;389:631-635.
34. Imamura T, Takase M, Nishihara A, et al. Smad6 inhibits signalling by the TGF-beta superfamily. Nature. 1997;389:622-626.
35. Cordeiro MF, Khaw PT. The healing optic nerve in glaucoma: transforming growth factor beta and optic nerve head remodeling. Br J Ophthalmol. 1999;83:132-133.
36. Quigley HA, Addicks EM. Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol. 1981;99:137-143.
37. Fukuchi T, Ueda J, Hanyu T, Abe H, Sawaguchi S. Changes in transforming growth factor-beta and platelet-derived growth factor in the optic nerve head in monkey experimental glaucoma. Nippon Ganka Gakkai Zasshi. 1999;103:193-200.
38. Fuchshofer R, Birke M, Welge-Lussen U, Kook D, Lutjen-Drecoll E. Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes. Invest Ophthalmol Vis Sci. 2005;46:568-578.
39. Gottanka J, Chan D, Eichhorn M, Lutjen-Drecoll E, Ethier CR. Effects of TGF-β2 in perfused human eyes. Invest Ophthalmol Vis Sci. 2004;45:153-158.
40. Kirwan RP, Crean JK, Fenerty CH, Clark AF, O'Brien CJ. Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head. J Glaucoma. 2004;13:327-334.
41. Kirwan RP, Fenerty CH, Crean J, Wordinger RJ, Clark AF, O'Brien CJ. Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro. Mol Vis. 2005;11:798-810.