Pharmacokinetics and biodistribution of amikacin encapsulated in carrier erythrocytes

Journal of Antimicrobial Chemotherapy

Volumn 61, Issue 2, 2008, Pages 375-381

  Millán, Carmen Gutiérrez ^a   Castañeda, Aránzazu Zarzuelo ^a   López, Francisco González ^a   Marinero, Maria Luisa Sayalero ^a   Lanao, José M ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Aminoglycosides; Loaded erythrocytes; Tissue distribution

Indexed keywords

AMIKACIN; GLUTARALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; ENCAPSULATION; ERYTHROCYTE; KIDNEY CORTEX; KIDNEY MEDULLA; LIVER; LUNG; MALE; MEAN RESIDENCE TIME; NONHUMAN; PHAGOCYTOSIS; RAT; RETICULOENDOTHELIAL SYSTEM; SPLEEN; SUSTAINED DRUG RELEASE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

AMIKACIN; ANIMALS; DRUG CARRIERS; DRUG COMPOUNDING; ERYTHROCYTES; MALE; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 38449087460     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm477     Document Type: Article

References (23)

1. Gutiérrez Millán C, Sayalero Marinero ML, Zarzuelo Castañeda A et al. Drug, enzyme and peptide delivery using erythrocytes as carriers. J Control Release 2004; 95: 27-49.
2. Lanao JM, Sayalero ML. Cells and cell ghosts as drug carriers. In: Torchilin VP, ed. Nanopardiculates as Drug Carriers. London: Imperial Collage Press, 2006; 329-48.
3. Gutiérrez Millán C, Zarzuelo Castañeda A, Sayalero Marinero ML et al. Factors associated with the performance of carrier erythrocytes obtained by hypotonic dialysis. Blood Cells Mol Dis 2004; 33: 132-40.
4. Zocchi E, Tonetti M, Polvani C et al. Encapsulation of doxorubicin in liver-targeted erythrocytes increases the therapeutic index of the drug in a murine metastitic model. Proc Natl Acad Sci USA 1989; 86: 2040-4.
5. Gasparini A, Chiarantini L, Kirch H et al. In vitro targeting of doxorubicin loaded canine erythrocytes to cytotoxic T-lymphocytes (CTLL). In: Magnani M, DeLoach JR, eds. Advances in Experimental Medicine and Biology, vol. 326, The Use of Resealed Erythrocytes as Carriers and Bioreactors. New York, NY: Plenum Press, 1992; 291-7.
6. Bax BE, Bain MD, Talbot PJ et al. Survival of carrier erythrocytes in vivo. Clin Sci 1999; 96: 171-8.
7. Stendahl O, Phagocytosis of Bacteria and Bacterial Pathogenicity. New York, NY: Cambridge University Press, 2006.
8. Belyi IF. Actin machinery of phagocytic cells: Universal target for bacterial attack. Microsc Res Tech 2002; 67: 432-40.
9. Salem II, Flasher DL, Duzgunes N. Liposome-encapsulated antibiotics. Methods Enzymol 2005; 391: 261-91.
10. Lecaroz C, Gamazo C, Blanco-Prieto MJ. Nanocarriers with gentamicin to treat intracellular pathogens. J Nanosci Nanotechnol 2006; 6 3296-302.
11. Eichler HG, Rameis H, Bauer K et al. Survival of gentamicin-loaded carrier erythrocytes in healthy human volunteers. Eur J Clin Invest 1986; 16: 39-42.
12. Gutiérrez Millán C, Zarzuelo Castañeda A, González López F et al. Encapsulation and in vitro evaluation of amikacin-loaded erythrocytes. Drug Deliv 2005; 12: 409-16.
13. Santos B, Sayalero ML, Zarzuelo A et al. Determination of amikacin in biological tissues Py HPLC. J Liquid Chromalogr Relat Technol 2002; 25: 463-73.
14. Karol MD, Veng-Pedersen P, Brashear RE. Diffusion and flow transfer of theophylline across the blood-brain barrier pharmacokinetic analysis. J Pharmacokinet Biopharm 1983; 11: 273-87.
15. Ebling WF, Wada DR, Stanski DR. From piecewise to full physiological pharmacokinetic modelling: Applied to thiopental disposition in the rat. J Pharmacokinet Biopharm 1994; 22: 259-92.
16. Gillespie WR, Cheng H. A multidimensional deconvolution method for evaluating the absorption of drugs undergoing reversible metabolism and presystemic metabolite formation. J Pharm Sci 1993; 82: 1085-9.
17. Yamaoka K, Nakagawa T, Uno T. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 1978; 6: 547-58.
18. McNamara PJ, Fleishaker JC, Hayden TL. Mean residence time in peripheral tissue. J Pharmacokinet Biopharm 1987; 15: 439-50.
19. Weitzman EA. Analyzing qualitative data with computer software. Health Serv Res 1999; 34: 1241-63.
20. Gening TP, Manuilov KK. Pharmacokinetics of an antibiotic administered in cell carriers. Antibiot Khimioter 1991; 36: 19-20.
21. Trapote MA, Arévalo MA, Lanao JM et al. Pharmacokinetic and nephrotoxic study of gentamicin in rabbits using a new dosage regimen. Eur J Drug Metab Pharmacokinet 1989; 14: 169-75.
22. Zarzuelo A, Lanao JM, López FG et al. Influence of the infusion rate on disposition of netilmicin in the isolated rat perfused kidney. Eur J Pharm Sci 2002; 16: 133-41.
23. DeLoach JR, Peters S, Pinkard O et al. Effect of glutaraldehyde on enzyme-loaded erythrocytes. Biochim Biophys Acta 1977; 496: 507-15.