Occupational exposure to ionizing radiation has no effect on T- and B-cell total counts or percentages of helper, cytotoxic and activated T-cell subsets in the peripheral circulation of male radiation workers

International Journal of Radiation Biology

Volumn 80, Issue 7, 2004, Pages 493-498

  Rees, G S ^a   Daniel, C P ^a   Morris, S D ^b   Whitehouse, C A ^a   Binks, K ^a   MacGregor, D H ^b   Tawn, E J ^a  

^a WESTLAKES RESEARCH INSTITUTE   (United Kingdom)

^b SELLAFIELD LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN;

ADULT; ARTICLE; B LYMPHOCYTE; CELL COUNT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HUMAN; IMMUNOCOMPETENT CELL; IONIZING RADIATION; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NONMEDICAL OCCUPATIONS; OCCUPATIONAL EXPOSURE; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; SMOKING; STATISTICAL ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADULT; B-LYMPHOCYTES; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; SMOKING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 3843145137     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000410001725099     Document Type: Article

References (21)

1. AKIYAMA, M., 1995, Late effects of radiation on the human immune-system - an overview of immune-response among the atomic-bomb survivors. International Journal of Radiation Biology, 68, 497-508.
2. AKIYAMA, M., YAMAKIDO, M., KOBUKE, K., DOCK, D. S., HAMILTON, H. B., AWA, A. A. and KATO, H., 1983, Peripheral lymphocyte-response to PHA and T-cell population among atomic-bomb survivors. Radiation Research, 93, 572-580.
3. AKIYAMA, M., ZHOU, O. L., KUSUNOKI, Y., KYOIZUMI, S., KOHNO, N., AKIBA, S. and DELONGCHAMP, R. R., 1989, Age and dose related alteration of in vitro mixed lymphocyte culture response of blood-lymphocytes from A-bomb survivors. Radiation Research, 117, 26-34.
4. CHANDRA, R. K., 2002, Nutrition and the immune system from birth to old age. European Journal of Clinical Nutrition, 56 (Suppl. 3), S73-76.
5. CHANG, W. P., HWANG, J. S., HUNG, M. C., HU, T. H., LEE, S. D. and HWANG, B. F., 1999, Chronic low-dose gamma-radiation exposure and the alteration of the distribution of lymphocyte subpopulations in residents of radioactive buildings. International Journal of Radiation Biology, 75, 1231-1239.
6. HAYASHI, T., KUSUNOKI, Y., HAKODA, M., MORISHITA, Y., KUBO, Y., MAKI, M., KASAGI, F., KODAMA, K., MACPHEE, D. G. and KYOIZUMI, S., 2003, Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. International Journal of Radiation Biology, 79, 129-136.
7. KITE, A. V. and BRITCHER, A. R., 1996, Uncertainties in recorded photon radiation doses at Sellafield. Radiation Protection Dosimetry, 67, 23-32.
8. KODAMA, K., FUJIWARA, S., YAMADA, M., KASAGI, F., SHIMIZU, Y. and SHIGEMATSU, I., 1996, Profiles of non-cancer diseases in atomic-bomb survivors. World Health Statistics Quarterly, 49, 7-16.
9. KUSUNOKI, Y., AKIYAMA, M., KYOIZUMI, S., BLOOM, E. T. and MAKINODAN, T., 1988, Age-related alteration in the composition of immunocompetent blood-cells in atomic-bomb survivors. International Journal of Radiation Biology, 53, 189-198.
10. KUSUNOKI, Y., HAYASHI, T. and KYOIZUMI, S., 2001b, T-cell responses to mitogens in atomic-bomb survivors: radiation effects on mitogen responsiveness are apparent in survivors who had not been diagnosed with cancer prior to testing. Radiation Research, 156, 564-565.
11. KUSUNOKI, Y., HAYASHI, T., MORISHITA, Y., YAMAOKA, M., MAKI, M., HAKODA, M., KODAMA, K., BEAN, M. A. and KYOZUMI, S., 2001a, T-cell responses to mitogens in atomic-bomb survivors: a decreased capacity to produce interleukin 2 characterizes the T-cells of heavily irradiated individuals. Radiation Research, 155, 81-88.
12. KUSUNOKI, Y., KYOIZUMI, S., HIRAI, Y., SUZUKI, T., NAKASHIMA, E., KODAMA, K. and SEYAMA, T., 1998, Flow cytometry measurements of subsets of T, B and NK cells in peripheral blood lymphocytes of atomic-bomb survivors. Radiation Research, 150, 227-236.
13. KUSUNOKI, Y., KYOIZUMI, S., YAMAOKA, M., KASAGI, F., KODAMA, K. and SEYAMA, T., 1999, Decreased proportion of CD4 T cells in the blood of atomic-bomb survivors with myocardial infarction. Radiation Research, 152, 539-543.
14. KUSUNOKI, Y., YAMAOKA, M., KASAGI, F., HAYASHI, T., KOYAMA, K., KODAMA, K., MACPHEE, D. G. and KYOIZUMI, S., 2002, T cells of atomic-bomb survivors respond poorly to stimulation by Staphylococcus aureus toxins in vitro: does this stem from their peripheral lymphocyte populations having a diminished naive CD4 T-cell content? Radiation Research, 158, 715-724.
15. MAKINODAN, T., LUBINSKI, J. and FONG, T. C., 1987, Cellular, biochemical, and molecular-basis of T-cell senescence. Archives of Pathology and Laboratory Medicine, 111, 910-914.
16. + CD45RA) T lymphocytes and increase of serum immunoglobulin G due to perceived job stress in Japanese nuclear electric power plant workers. Journal of Occupational and Environmental Medicine, 42, 143-150.
17. SOPORI, M., 2002, Effects of cigarette smoke on the immune system. Nature Reviews Immunology, 2, 372-377.
18. TUSCHL, H., KOVAC, R. and WOTTAWA, A., 1990, Lymphocyte-T subsets in occupationally exposed persons. International Journal of Radiation Biology, 58, 651-659.
19. TUSCHL, H., STEGER, F. and KOVAC, R., 1995, Occupational exposure and its effect on some immune parameters. Health Physics, 68, 59-66.
20. WONG, F. L., YAMADA, M., SASAKI, H., KODAMA, K., AKIBA, S., SHIMAOKA, K. and HOSODA, Y., 1993, Non-cancer disease incidence in the atomic-bomb survivors - 1958-1986. Radiation Research, 135, 418-430.
21. YARILIN, A. A., BELYAKOV, I. M., KUSMENOK, O. I., ARSHINOV, V. Y., SIMONOVA, A. V., NADEZHINA, N. M. and GNEZDITSKAYA, E. V., 1993, Late T-cell deficiency in victims of the Chernobyl radiation accident - possible mechanisms of induction. International Journal of Radiation Biology, 63, 519-528.