Cobalamin reduces homocysteine in older adults on folic acid-fortified diet: A pilot, double-blind, randomized, placebo-controlled trial [10]

Journal of the American Geriatrics Society

Volumn 52, Issue 8, 2004, Pages 1410-1412

  Garcia, Angeles ^a   Pulman, Kate ^a   Zanibbi, Katherine ^a   Day, Andrew ^a   Galarneau, Linda ^b   Freedman, Morris ^c  

^a QUEEN S UNIVERSITY   (Canada)

^b St Mary's of the Lake Hospital   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE; MULTIVITAMIN;

AGED; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DOUBLE BLIND PROCEDURE; ERYTHROCYTE; FEMALE; HUMAN; LETTER; MALE; MENTAL CONCENTRATION; MENTAL HEALTH; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL;

EID: 3843131731     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2004.52379_10.x     Document Type: Letter

References (8)

1. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis. BMJ 2002;325:1202-1208.
2. McCaddon A, Hudson P, Davies G et al. Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord 2001;12:309-313.
3. Seshadri S, Beiser A, Selhub J et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-483.
4. Garcia A, Haron Y, Pulman K et al. Increases in homocysteine are related to worsening of Stroop scores in normal elderly subjects. A prospective follow-up study. J Gerontol in press.
5. Joosten E, van den Berg A, Riezler R et al. Metabolic evidence that deficiencies of B12 (cobalamin), folate, and vitamin B6 occur commonly in elderly people. Am J Clin Nutr 1993;58:468-476.
6. Arnadottir M, Hultberg B, Nilsson-Ehle P et al. The effect of reduced glomerular filtration rate on plasma total homocysteine concentrations. Scand J Clin Lab Invest 1996;56:41-46.
7. Selhub J, Jaques PF, Rosenberg IH et al. Serum total homocysteine concentrations in the third national health and nutrition examination survey (1991-94): Population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 1999;131:331-339.
8. Garcia A, Haron Y, Evans L et al. Metabolic markers of cobalamin deficiency and cognitive function in normal older adults. J Am Geriatr Soc 2004;52:66-71.