Clinical evaluation of a new molecular method for detection of micrometastases in head and neck squamous cell carcinoma

Archives of Otolaryngology - Head and Neck Surgery

Volumn 130, Issue 8, 2004, Pages 937-942

  Shores, Carol G ^a,c   Yin, Xiaoying ^a   Funkhouser, William ^a   Yarbrough, Wendell ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 14;

ARTICLE; CANCER DIAGNOSIS; CERVICAL LYMPH NODE; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; FALSE POSITIVE REACTIONS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; KERATINS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MOLECULAR DIAGNOSTIC TECHNIQUES; NECK DISSECTION; NEOPLASM STAGING; NORTH CAROLINA; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; WOMEN'S HEALTH;

EID: 3843093942     PISSN: 08864470     EISSN: None     Source Type: Journal    
DOI: 10.1001/archotol.130.8.937     Document Type: Article

References (20)

1. Tu G. Upper neck (level II) dissection for NO neck supraglottic carcinoma. Laryngoscope. 1999;109:467-470.
2. Barrera J, Miller M, Said S, Jafek BW, Campana JP, Shroyer KR. Detection of occult cervical micrometastases in patients with head and neck squamous cell cancer. Laryngoscope. 2003;113:892-896.
3. Ambrosch P, Brinck U. Detection of nodal micrometastasis in head and neck cancer by serial sectioning and immunostaining. Oncology. 1996;10:1221-1226.
4. Hamakawa H, Takemura K, Sumida T, Kayahara H, Tanioka H, Sogawa K. Histological study on pN upgrading of oral cancer. Virchows Arch. 2000;437:116-121.
5. Enepekides D, Sultanem K, Nguyen C, Shenouda G, Black MJ, Rochon L. Occult cervical metastases: immunoperoxidase analysis of the pathologically negative neck. Otolaryngol Head Neck Surg. 1999;120:713-717.
6. Woolgar J. Micrometastasis in oral/oropharyngeal squamous cell carcinoma: incidence, histopathological features and clinical implications. Br J Oral Maxillofac Surg. 1999;37:181-186.
7. Rhee D, Wenig B, Smith R. The significance of immunohistochemically demonstrated nodal micrometastases in patients with squamous cell carcinoma of the head and neck. Laryngoscope. 2002;112:1970-1974.
8. Ferlito A, Shaha A, Rinaldo A. The incidence of lymph node micrometastases in patients pathologically staged NO in cancer of oral cavity and oropharynx. Oral Oncol. 2002;38:3-5.
9. Hermanek P, Hutter R, Sobin L, Wittekind C. Classification of isolated tumor cells and micrometastasis. Cancer. 1999;86:2668-2673.
10. Anderson P, Cambronero E, Shaha A, Shah JP. The extent of neck disease after regional failure during observation of the NO neck. Am J Surg. 1996;172:689-691.
11. Moll R, Franke W, Schiller D. The catalogue of human cytokeratins: patterns of expression in normal epithelia, tumors, and cultured cells. Cell. 1982;31:11-24.
12. Osaki T, Oyama T, Gu C-D, et al. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small cell lung cancer. J Clin Oncol. 2002;20:2930-2936.
13. Yasuda K, Adachi Y, Shiraishi N, Yamaguchi K, Hirabayashi Y, Kitano S. Pattern of lymph node micrometastasis and prognosis of patients with colorectal cancer. Ann Surg Oncol. 2001;8:300-304.
14. Ishigami S, Natsugoe S, Tokuda K, et al. Clinical impact of micrometastasis of the lymph node in gastric cancer. Am Surg. 2003;69:573-577.
15. Reis-Filho J, Simpson P, Martins A, Preto A, Gartner F, Schmitt FC. Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch. 2003;443:122-132.
16. Becker M, Yu K, Shores C, Yarbrough WG. Molecular assay to detect metastatic head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004;130:21-27.
17. Tsubokawa F, Nishisaka T, Takeshima Y, Inai K. Heterogeneity of expression of cytokeratin subtypes in squamous cell carcinoma of the lung: with special reference to CK14 overexpression in cancer of high-proliferative and lymphogenous metastatic potential. Pathol Int. 2002;52:286-293.
18. Woolgar J, Rogers S, Lowe D, Brown JS, Vaughan ED. Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol. 2003;39:130-137.
19. Doki Y, Ishikawa O, Mano M, et al. Cytokeratin deposits in lymph nodes show a distinct clinical significance from lymph node micrometastasis in human esophageal cancers. J Surg Res. 2002;107:75-81.
20. Hamakawa H, Fukizumi M, Bao Y, et al. Genetic diagnosis of micrometastasis based on SCC antigen mRNA in cervical lymph nodes of head and neck cancer. Clin Exp Metastasis. 1999;17:593-599.