Neuronal ubiquitinated intranuclear inclusions in familial and non-familial frontotemporal dementia of the motor neuron disease type associated with amyotrophic lateral sclerosis

Journal of Neuropathology and Experimental Neurology

Volumn 63, Issue 8, 2004, Pages 801-811

  Bigio, Eileen H ^a   Johnson, Nancy A ^a   Rademaker, Alfred W ^a   Fung, Bing B ^a   Mesulam, M Marsel ^a   Siddique, Nailah ^a   Dellefave, Lisa ^a   Caliendo, Janice ^a   Freeman, Stefanie ^a   Siddique, Teepu ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Amyotrophic lateral sclerosis; Familial dementia; Frontotemporal dementia; Frontotemporal dementia of the motor neuron disease type; Motor neuron disease; Ubiquitin

Indexed keywords

UBIQUITIN;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL INCLUSION; CELL LOSS; CLINICAL ARTICLE; DENTATE GYRUS; DISEASE ASSOCIATION; FAMILIAL DISEASE; FAMILY HISTORY; FEMALE; FRONTAL CORTEX; FRONTOTEMPORAL DEMENTIA; GLIOSIS; HUMAN; MALE; MOTOR NEURON DISEASE; NERVE CELL; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; TAUOPATHY; TEMPORAL CORTEX; UBIQUITINATION;

EID: 3843089299     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/63.8.801     Document Type: Article

References (12)

1. Wakabayashi K, Piao Y-S, Hayashi S, Kakita A, Yamada M, Takahashi H. Ubiquitinated neuronal inclusions in the neostriatum in patients with amyotrophic lateral sclerosis with and without dementia-A study of 60 patients 31 to 87 years of age. Clin Neuropathol 2001;20:47-52
2. Trojanowski JQ, Dickson D. Update on the neuropathological diagnosis of frontotemporal dementias. J Neuropathol Exp Neurol 2001;60:1123-26
3. McKhann GM, Albert MS, Grossman M, Miller B, Dickson D, Trojanowski JQ. Clinical and pathological diagnosis of frontotemporal dementia: Report of the Work Group on Frontotemporal Dementia and Pick's disease. Arch Neurol 2001;58:1803-9
4. Okamoto K, Hirai S, Yamazaki T, Sun XY, Nakazato Y. New ubiquitin-positive intraneuronal inclusion in the extra-motor cortices in patients with amyotrophic lateral sclerosis. Neurosci Lett 1991;129: 233-36
5. Wightman G, Anderson VE, Martin J, et al. Hippocampal and neocortical ubiquitin-immunoreactive inclusions in amyotrophic lateral sclerosis with dementia. Neurosci Lett 1992;139:269-74
6. Jackson M, Lowe J. The new neuropathology of degenerative frontotemporal dementias. Acta Neuropathol 1996;91:127-34
7. Lipton AM, White III CL, Bigio EH. FTLD-MND-type predominates in 76 cases of frontotemporal degeneration. Acta Neuropathol (in press)
8. Woulfe J, Kertesz A, Munoz DG. Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusions. Acta Neuropathol 2001;102:94-102
9. Mackenzie IRA, Feldman H. Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases. Acta Neuropathol 2003;105:543-48
10. Houropian DS, Thai L, Katzman R, et al. Dementia and motor neuron disease: Morphometric, biochemical, and Golgi studies. Ann Neurol 1984;16:305-13
11. Ince PG, Shaw PJ, Slade JY, Jones C, Hudgson P. Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn Superoxide dismutase gene: Pathological and immunocytochemical changes. Acta Neuropathol 1996;92:395-403
12. Hosier BA, Siddique T, Sapp PC, et al. Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-22. JAMA 2000;284:1664-69