Improving the prediction of exceptionally poor tableting performance: An investigation into Hiestand's "special case"

Journal of Pharmaceutical Sciences

Volumn 93, Issue 8, 2004, Pages 2017-2021

  Mullarney, Matthew P ^a   Hancock, Bruno C ^a  

^a PFIZER INC   (United States)

Author keywords

Compaction; Compression; Excipients; Mechanical properties; Tableting

Indexed keywords

ASCORBIC ACID; CELLULOSE ACETATE; CITRIC ACID; GLYCEROL BEHENATE; GLYCEROL LAURATE; LAURIC ACID DERIVATIVE; PARACETAMOL; PHENACETIN; STARCH GLYCOLATE SODIUM; STEARIC ACID; TARTARIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; DRUG FORMULATION; DRUG MANUFACTURE; DYNAMICS; HARDNESS; TABLET; TECHNOLOGY; TENSILE STRENGTH; THEORY;

EID: 3843078702     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20108     Document Type: Article

References (11)

1. Hiestand EN. 2002. Mechanical behavior of solids: Elements of powder beds and compacts. In: Mechanics and physical principles for powders and compacts, 2nd ed. Stowell JG, editor. West Lafayette, IN: SSCI Inc., pp 21-48.
2. Hiestand EN. 1989. The basis for practical applications of the tableting indices. Pharm Technol Int 8:54-66.
3. Joiris E, Martino PD, Berneron C, Guyot-Hermann A-M, Guyot J-C. 1998. Compression behavior of orthorhombic paracetamol. Pharm Res 15:1122-1130.
4. Hiestand EN. 1996. Rationale for and the measurement of tableting indices. In: Pharmaceutical powder compaction technology. Alderborn G, Nystrom C, editors. New York: Marcel Dekker, pp 219-244.
5. Hiestand E, Smith DP. 1984. Indices of tableting performance. Powder Technol 38:145-159.
6. Mullarney MP, Hancock BC, Carlson GT, Ladipo DD, Langdon BA. 2003. The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets. Int J Pharm 257:227-236.
7. Hancock BC, Colvin JT, Mullarney MP, Zinchuk AV. 2003. The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets. Pharm Technol 27:64-80.
8. Kassem MAA, El-Bayoumi T. 1983. Manufacture and physical characteristics of directly compressed tablets of different types of L-ascorbic acid. J Drug Res 14:141-149.
9. Kawashima Y, Imai M, Takeuchi H, Yamamoto H, Kamiya K, Hino T. 2003. Improved flowability and compactibility of spherically agglomerated crystals of ascorbic acid for direct tableting designed by spherical crystallization process. Powder Technol 130:283-289.
10. Munoz N, Ferrero C, Munoz-Ruiz A, Velasco MV, Jimenez-Castellanos MR. 1998. Effect of Explotab on the tabletability of a poorly soluble drug. Drug Dev Ind Pharm 24:785-791.
11. Riepma KA, Vromans H, Lerk CF. 1978. Characteristics by scanning electron microscopy of powders mixed with magnesium stearate. Powder Technol 20:75-82.