Pharmacokinetics and bioequivalence of trimebutine dispersive tablet in healthy subjects

Yaoxue Xuebao

Volumn 39, Issue 3, 2004, Pages 208-211

  Jiang, Hong ^a   Ding, Li ^a   Yang, Jin ^a   Huang, Xin ^a   Liu, Guang Yu ^b   Zhang, Zheng Xing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Bioequaivalence; HPLC ESI MS; Pharmacokinelics; Sibutramine; Trimebutine

Indexed keywords

AMMONIUM ACETATE; BICARBONATE; CYCLOHEXANE; METHANOL; PHOSPHODIESTERASE I; SIBUTRAMINE; TRIMEBUTINE; GASTROINTESTINAL AGENT;

ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION MONITORING; NORMAL HUMAN; PLASMA; SEPARATION TECHNIQUE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; ADULT; COMPARATIVE STUDY; MALE; PHARMACOKINETICS; TABLET;

ADULT; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GASTROINTESTINAL AGENTS; HUMANS; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TABLETS; THERAPEUTIC EQUIVALENCY; TRIMEBUTINE;

EID: 3843061400     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Lavit M, Saivin S, Boudra H, et al. Determination of trimebution and desmethyltrimebutine in human plasma by HPLC [J]. Arzneimittelforsch, 2000,50(7):640-644.
2. Saivin S, Lavit M, Michel F, et al. Pharmacokinetics and bioequivalence of two trimebutine formulations in healthy volunteers using desmethyl- trimebutine levels [J]. Arzneimittelforsch, 2000,50(8):717-721.
3. Wang H, Zhou H, Horimoto S, et al. Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry [J]. J Chromatogr B Anal Technol Biomed Life Sci, 2002,779(2):173-187.
4. Yang J, Wang CJ, Liu XQ, et al. Development of bioavailability program package 2.0 [J]. Chin J Clin Pharmacol, 2003,19(2):125-127.