Toxicity and gut associated lymphoid tissue translocation of polymyxin B orally administered by alginate/chitosan microparticles in rats

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 1, 2008, Pages 21-26

  Coppi, Gilberto ^a   Bondi, Moreno ^a   Coppi, Andrea ^a   Rossi, Tiziana ^a   Sergi, Santo ^a   Iannuccelli, Valentina ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ALGINATE; CALCIUM ION; CHITOSAN; POLYMYXIN B; WATER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CROSS LINKING; DIET RESTRICTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG URINE LEVEL; FEEDING; GASTROINTESTINAL TOXICITY; IN VIVO STUDY; INCIDENCE; INTESTINE LYMPHATIC TISSUE; LD 50; LYMPHATIC SYSTEM; MALE; MONITORING; MORTALITY; NONHUMAN; PEYER PATCH; RAT; SAFETY; SPRAY DRYING;

ACUTE TOXICITY TESTS; ADMINISTRATION, ORAL; ALGINATES; ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT; CHITOSAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DYSPNEA; GASTROINTESTINAL HEMORRHAGE; GLUCURONIC ACID; HEMORRHAGIC DISORDERS; HEXURONIC ACIDS; LYMPHOID TISSUE; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; MICROSPHERES; PARTICLE SIZE; POLYMYXIN B; RATS; RATS, SPRAGUE-DAWLEY; STOMACH;

EID: 38349181604     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.1.0003     Document Type: Article

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