메뉴 건너뛰기




Volumn 21, Issue 1-3, 2008, Pages 137-150

Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver

Author keywords

Bile acids; Cell volume; Insulin Resistance; PKB; Proteolysis; Rapamycin; Tauroursodeoxycholate

Indexed keywords

1,4 BIS(2 CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BILE ACID; BUCLADESINE; EPIGALLOCATECHIN GALLATE; INSULIN; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM ION; PROTEIN KINASE B; PROTEIN KINASE C INHIBITOR; RAPAMYCIN; TAUROLITHOCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID;

EID: 38349181088     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000113756     Document Type: Article
Times cited : (12)

References (49)
  • 1
    • 33645738747 scopus 로고    scopus 로고
    • Endocrine functions of bile acids
    • Houten SM, Watanabe M, Auwerx J: Endocrine functions of bile acids. EMBO J 2006;25:1419-1425.
    • (2006) EMBO J , vol.25 , pp. 1419-1425
    • Houten, S.M.1    Watanabe, M.2    Auwerx, J.3
  • 2
    • 0034945397 scopus 로고    scopus 로고
    • Ursodeoxycholic acid mechanisms of action and clinical use in hepatobiliary disorders
    • Lazaridis KN, Gores GJ, Lindor KD: Ursodeoxycholic acid mechanisms of action and clinical use in hepatobiliary disorders. J Hepatol 2001;35:134-146.
    • (2001) J Hepatol , vol.35 , pp. 134-146
    • Lazaridis, K.N.1    Gores, G.J.2    Lindor, K.D.3
  • 3
    • 33744920572 scopus 로고    scopus 로고
    • Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis
    • Beuers U: Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006;3:318-328.
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , pp. 318-328
    • Beuers, U.1
  • 4
    • 3042594002 scopus 로고    scopus 로고
    • Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis
    • Häussinger D, Kurz AK, Wettstein M, Graf D, vom Dahl S, Schliess F: Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. Gastroenterology 2003;124:1476-1487.
    • (2003) Gastroenterology , vol.124 , pp. 1476-1487
    • Häussinger, D.1    Kurz, A.K.2    Wettstein, M.3    Graf, D.4    vom Dahl, S.5    Schliess, F.6
  • 5
    • 1242291934 scopus 로고    scopus 로고
    • Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes
    • Han SI, Studer E, Gupta S, Fang Y, Qiao L, Li W, Grant S, Hylemon PB, Dent P: Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes. Hepatology 2004;39:456-463.
    • (2004) Hepatology , vol.39 , pp. 456-463
    • Han, S.I.1    Studer, E.2    Gupta, S.3    Fang, Y.4    Qiao, L.5    Li, W.6    Grant, S.7    Hylemon, P.B.8    Dent, P.9
  • 7
    • 0041322990 scopus 로고    scopus 로고
    • Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
    • Reinehr R, Graf D, Häussinger D: Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. Gastroenterology 2003;125:839-853.
    • (2003) Gastroenterology , vol.125 , pp. 839-853
    • Reinehr, R.1    Graf, D.2    Häussinger, D.3
  • 9
    • 26244441014 scopus 로고    scopus 로고
    • The Farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism
    • Claudel T, Staels B, Kuipers F: The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol 2005;25:2020-2030.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 11
    • 0028954737 scopus 로고
    • Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: A role for PKC
    • Bouscarel B, Gettys TW, Fromm H, Dubner H: Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: a role for PKC. Am J Physiol 1995;268:G300-310.
    • (1995) Am J Physiol , vol.268
    • Bouscarel, B.1    Gettys, T.W.2    Fromm, H.3    Dubner, H.4
  • 13
    • 33750970321 scopus 로고    scopus 로고
    • Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver
    • Graf D, Kohlmann C, Haselow K, Gehrmann T, Bode JG, Häussinger D: Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver. Hepatology 2006;44:1206-1217.
    • (2006) Hepatology , vol.44 , pp. 1206-1217
    • Graf, D.1    Kohlmann, C.2    Haselow, K.3    Gehrmann, T.4    Bode, J.G.5    Häussinger, D.6
  • 15
    • 0034663645 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver
    • Kurz AK, Block C, Graf D, vom Dahl S, Schliess F, Häussinger D: Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. Biochem J 2000;350:1207-1213.
    • (2000) Biochem J , vol.350 , pp. 1207-1213
    • Kurz, A.K.1    Block, C.2    Graf, D.3    vom Dahl, S.4    Schliess, F.5    Häussinger, D.6
  • 16
    • 0036241214 scopus 로고    scopus 로고
    • Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner
    • Graf D, Kurz AK, Fischer R, Reinehr R, Häussinger D: Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. Gastroenterology 2002;122:1411-1427.
    • (2002) Gastroenterology , vol.122 , pp. 1411-1427
    • Graf, D.1    Kurz, A.K.2    Fischer, R.3    Reinehr, R.4    Häussinger, D.5
  • 17
    • 2442674271 scopus 로고    scopus 로고
    • Involvement of integrins and Src in insulin signaling towards autophagic proteolysis in rat liver
    • Schliess F, Reissmann R, Reinehr R, vom Dahl S, Häussinger D: Involvement of integrins and Src in insulin signaling towards autophagic proteolysis in rat liver. J Biol Chem 2004;279:21294-21301.
    • (2004) J Biol Chem , vol.279 , pp. 21294-21301
    • Schliess, F.1    Reissmann, R.2    Reinehr, R.3    vom Dahl, S.4    Häussinger, D.5
  • 18
    • 0030941434 scopus 로고    scopus 로고
    • Experimental methods in hepatology. Guidelines of the German Association for the Study of the Liver (GASL). Liver perfusion-technique and applications
    • vom Dahl S, Häussinger D: Experimental methods in hepatology. Guidelines of the German Association for the Study of the Liver (GASL). Liver perfusion-technique and applications. Z Gastroenterol 1997;35:221-226.
    • (1997) Z Gastroenterol , vol.35 , pp. 221-226
    • vom Dahl, S.1    Häussinger, D.2
  • 20
    • 0031050706 scopus 로고    scopus 로고
    • Osmoregulated taurine transport in H4IIE rat hepatoma cells and perfused rat liver
    • Warskulat U, Wettstein M, Häussinger D: Osmoregulated taurine transport in H4IIE rat hepatoma cells and perfused rat liver. Biochem J 1997;321:683-690.
    • (1997) Biochem J , vol.321 , pp. 683-690
    • Warskulat, U.1    Wettstein, M.2    Häussinger, D.3
  • 23
    • 0035088560 scopus 로고    scopus 로고
    • Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes
    • Rippin SJ, Hagenbuch B, Meier PJ, Stieger B: Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes. Hepatology 2001;33:776-782.
    • (2001) Hepatology , vol.33 , pp. 776-782
    • Rippin, S.J.1    Hagenbuch, B.2    Meier, P.J.3    Stieger, B.4
  • 24
    • 0025250354 scopus 로고
    • Expression of the bile acid transport protein during liver development and in hepatoma cells
    • von Dippe P, Levy D: Expression of the bile acid transport protein during liver development and in hepatoma cells. J Biol Chem 1990 15;265:5942-5945.
    • (1990) J Biol Chem , vol.15 , Issue.265 , pp. 5942-5945
    • von Dippe, P.1    Levy, D.2
  • 25
    • 0037007124 scopus 로고    scopus 로고
    • The insulin signalling pathway
    • Lizcano JM, Alessi DR: The insulin signalling pathway. Curr Biol 2002;12:R236-R238.
    • (2002) Curr Biol , vol.12
    • Lizcano, J.M.1    Alessi, D.R.2
  • 28
    • 0028988138 scopus 로고
    • SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC: SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995;364:229-233.
    • (1995) FEBS Lett , vol.364 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3    Meier, R.4    Cohen, P.5    Gallagher, T.F.6    Young, P.R.7    Lee, J.C.8
  • 29
    • 0038172651 scopus 로고    scopus 로고
    • Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms
    • Graf D, Reinehr R, Kurz AK, Fischer R, Häussinger D: Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms. Arch Biochem Biophys 2003;415:34-42.
    • (2003) Arch Biochem Biophys , vol.415 , pp. 34-42
    • Graf, D.1    Reinehr, R.2    Kurz, A.K.3    Fischer, R.4    Häussinger, D.5
  • 31
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P: Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000;351:95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 34
    • 0034878320 scopus 로고    scopus 로고
    • Insulin resistance by loop diuretics and hyperosmolarity in perfused rat liver
    • Schliess F, vom Dahl S, Häussinger D: Insulin resistance by loop diuretics and hyperosmolarity in perfused rat liver. Biol Chem 2001;382:1063-1069.
    • (2001) Biol Chem , vol.382 , pp. 1063-1069
    • Schliess, F.1    vom Dahl, S.2    Häussinger, D.3
  • 35
    • 0030906632 scopus 로고    scopus 로고
    • Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C
    • Jones BA, Rao YP, Stravitz RT, Gores GJ: Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C. Am J Physiol 1997;272:G1109-G1115.
    • (1997) Am J Physiol , vol.272
    • Jones, B.A.1    Rao, Y.P.2    Stravitz, R.T.3    Gores, G.J.4
  • 36
  • 37
    • 25144462468 scopus 로고    scopus 로고
    • Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines
    • Shah SA, Looby E, Volkov Y, Long A, Kelleher D: Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines. Eur J Cancer 2005;41:2160-2169.
    • (2005) Eur J Cancer , vol.41 , pp. 2160-2169
    • Shah, S.A.1    Looby, E.2    Volkov, Y.3    Long, A.4    Kelleher, D.5
  • 38
    • 0023834876 scopus 로고
    • Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
    • Takayama S, White MF, Kahn CR: Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem 1988;263:3440-3447.
    • (1988) J Biol Chem , vol.263 , pp. 3440-3447
    • Takayama, S.1    White, M.F.2    Kahn, C.R.3
  • 40
    • 11144219992 scopus 로고    scopus 로고
    • Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase
    • Kimball SR, Siegfried BA, Jefferson LS: Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. J Biol Chem 2004 24;279:54103-54109.
    • (2004) J Biol Chem , vol.24 , Issue.279 , pp. 54103-54109
    • Kimball, S.R.1    Siegfried, B.A.2    Jefferson, L.S.3
  • 41
    • 5644285347 scopus 로고    scopus 로고
    • In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids
    • Mothe-Satney I, Gautier N, Hinault C, Lawrence J-CJ, Van Obberghen E: In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids. J Biol Chem 2004;279:42628-42637.
    • (2004) J Biol Chem , vol.279 , pp. 42628-42637
    • Mothe-Satney, I.1    Gautier, N.2    Hinault, C.3    Lawrence, J.-C.J.4    Van Obberghen, E.5
  • 42
    • 33750922694 scopus 로고    scopus 로고
    • Korsheninnikova E, Van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, Maassen JA: Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 2006;49:3049-3057.
    • Korsheninnikova E, Van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, Maassen JA: Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 2006;49:3049-3057.
  • 44
    • 33747871436 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes
    • Tsuchiya S, Tsuji M, Morio Y, Oguchi K: Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes. Toxicol Lett 2006;166:14-149.
    • (2006) Toxicol Lett , vol.166 , pp. 14-149
    • Tsuchiya, S.1    Tsuji, M.2    Morio, Y.3    Oguchi, K.4
  • 45
    • 0038381474 scopus 로고    scopus 로고
    • Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
    • Beuers U, Denk GU, Soroka CJ, Wimmer R, Rust C, Paumgartner G, Boyer JL: Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem 2003;278:1810-17818.
    • (2003) J Biol Chem , vol.278 , pp. 1810-17818
    • Beuers, U.1    Denk, G.U.2    Soroka, C.J.3    Wimmer, R.4    Rust, C.5    Paumgartner, G.6    Boyer, J.L.7
  • 47
    • 0032588907 scopus 로고    scopus 로고
    • Involvement of p38 MAPK in the regulation of proteolysis by liver cell hydration
    • Häussinger D, Schliess F, Dombrowski F, vom Dahl S: Involvement of p38 MAPK in the regulation of proteolysis by liver cell hydration. Gastroenterology 1999;116:921-935.
    • (1999) Gastroenterology , vol.116 , pp. 921-935
    • Häussinger, D.1    Schliess, F.2    Dombrowski, F.3    vom Dahl, S.4
  • 49
    • 0029020401 scopus 로고
    • Diabetes mellitus-induced alterations of hepatobiliary function
    • Watkins JB, Sanders RA: Diabetes mellitus-induced alterations of hepatobiliary function. Pharmacol Rev 1995;47:1-23.
    • (1995) Pharmacol Rev , vol.47 , pp. 1-23
    • Watkins, J.B.1    Sanders, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.