Correlation of pituitary histomorphometry with adrenocorticotrophic hormone response to domperidone administration in the diagnosis of equine pituitary pars intermedia dysfunction

Veterinary Pathology

Volumn 45, Issue 1, 2008, Pages 26-38

  Miller, Margaret A ^a   Pardo, I D ^a,b   Jackson, L P ^a   Moore, G E ^a   Sojka, J E ^a  

^a PURDUE UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ACTH; Adrenocorticotrophic hormone; Domperidone; Dopaminergic inhibition; Equine; Histomorphometry; Horses; Pituitary adenoma; Pituitary hyperplasia; Pituitary pars intermedia dysfunction

Indexed keywords

CORTICOTROPIN; DIAGNOSTIC AGENT; DOMPERIDONE; DOPAMINE RECEPTOR BLOCKING AGENT;

ANIMAL; ANIMAL DISEASE; ARTICLE; FEMALE; HORSE; HORSE DISEASE; HYPOPHYSIS DISEASE; HYPOPHYSIS INTERMEDIATE LOBE; MALE; METABOLISM; ORGAN SIZE; PATHOLOGY;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; DOMPERIDONE; DOPAMINE ANTAGONISTS; FEMALE; HORSE DISEASES; HORSES; MALE; ORGAN SIZE; PITUITARY DISEASES; PITUITARY GLAND, INTERMEDIATE;

EQUIDAE;

EID: 38349174799     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1354/vp.45-1-26     Document Type: Article

References (30)

1. Aleman M, Watson JL, Williams DC, LeCouteur RA, Nieto JE, Shelton GD: Myopathy in horses with pituitary pars intermedia dysfunction (Cushing's disease). Neuromuscul Disord 16:737-744, 2006
2. Amann JF, Smith RM, Ganjam VK, Paull WK, McClure RC, Green EM, Garner HE: Distribution and implications of β-endorphin and ACTH-immunoreactive cells in the intermediate lobe of the hypophysis in healthy equids. Am J Vet Res 48:323-327, 1987
3. Antakly T, Eisen H: Immunocytochemical localization of glucocorticoid receptor in target cells. Endocrinology 115:1984-1989, 1984
4. Antakly T, Sasaki A, Liotta AS, Palkovits M, Krieger DT: Induced expression of the glucocorticoid receptor in the rat intermediate pituitary lobe. Science 299:277-279, 1985
5. Barone JA: Domperidone: a peripherally acting dopamine-2 receptor antagonist. Ann Pharmacother 33:429-440, 1999
6. Berne RM, Levy MN: The hypothalamus and pituitary gland. In: Physiology, 4th ed., pp. 872-909. Mosby, St. Louis, MO, 1998
7. Boujon CE, Bestetti GE, Meier HP, Straub R, Junker U, Rossi GL: Equine pituitary adenoma: a functional and morphological study. J Comp Pathol 109:163-178, 1993
8. Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS: Domperidone: a review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. Drugs 24:360-400, 1982
9. Couëtil L, Paradis MR, Knoll J: Plasma adrenocorticotrophin concentration in healthy horses and in horses with clinical signs of hyperadrenocorticism. J Vet Intern Med 10:1-6, 1996
10. Cross DL, Redmond LM, Strickland JR: Equine fescue toxicosis: signs and solutions. J Anim Sci 73:899-908, 1995
11. Donaldson MT, Jorgensen AJR, Beech J: Evaluation of suspected pituitary pars intermedia dysfunction in horses with laminitis. J Am Vet Med Assoc 224:1123-1127, 2004
12. Donaldson MT, McDonnell SM, Schanbacher BJ, Lamb SV, McFarlane D, Beech J: Variation in plasma adrenocorticotrophic hormone concentration and dexamethasone suppression test results with season, age, and sex in healthy ponies and horses. J Vet Intern Med 19:217-222, 2005
13. Dybdal NO, Hargreaves KM, Madigan JE, Gribble DH, Kennedy PC, Stabenfeldt GH: Diagnostic testing for pituitary pars intermedia dysfunction in horses. J Am Vet Med 204:627-632, 1994
14. Frank N, Andrews FM, Sommardahl CS, Eiler H, Rohrback BW, Donnell RL: Evaluation of the combined dexamethasone suppression/thyrotropin-releasing hormone stimulation test for detection of pars intermedia pituitary adenomas in horses. J Vet Intern Med 20:987-993, 2006
15. Heinrichs M, Baumgartner W, Capen CC: Immunocytochemical demonstration of proopiomelanocortinderived peptides in pituitary adenomas of the pars intermedia in horses. Vet Pathol 27:419-425, 1990
16. LaPerle KMD, Capen CC: Endocrine system. In: Pathologic Basis of Veterinary Disease, ed. McGavin MD and Zachary JF, 4th ed., pp. 693-741. Mosby Elsevier, St. Louis, MO, 2007
17. McFarlane D, Donaldson MT, McDonnell SM, Cribb AE: Effects of season and sample handling on measurement of plasma a-melanocyte-stimulating hormone concentrations in horses and ponies. Am J Vet Res 65:1463-1468, 2004
18. McFarlane D, Dybdal N, Donaldson MT, Miller L, Cribb AE: Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction (PPID). J Neuroendocrinol 17:73-80, 2005
19. McFarlane D, Miller LM, Craig LE, Dybdal NO, Habecker PL, Miller MA, Patterson JS, Cribb AE: Agreement in histologic assessments of the pituitary pars intermedia in aged horses. Am J Vet Res 66:2055-2059, 2005
20. McKlveen TL, Jones JC, Sponenberg DP, Scarratt K, Ward DL, Aardema CH: Assessment of the accuracy of computed tomography for measurement of normal equine pituitary glands. Am J Vet Res 64:1387-1394, 2003
21. Millington WR, Dybdal NO, Dawson R Jr, Manzini C, Mueller GP: Equine Cushing's disease: differential regulation of β-endorphin processing in tumours of the intermediate pituitary. Endocrinology 123:1598-1604, 1988
22. Okada T, Shimomuro T, Oikawa M, Nambo Y, Kiso Y, Morikawa Y, Liptrap RM, Yamashiro S, Little PB, Sasaki F: Immunocytochemical localization of adrenocorticotropic hormone-immunoreactive cells of the pars intermedia in thoroughbreds. Am J Vet Res 58:920-924, 1997
23. Orth DN, Holscher MA, Wilson MG, Nicholson WE, Plue RD, Mount CD: Equine Cushing's disease: plasma immunoreactive pro-opiolipomelanocortin peptide and cortisol levels basally and in response to diagnostic tests. Endocrinology 110:1430-1441, 1982
24. Orth DN, Nicholson WE: Bioactive and immunoreactive adrenocorticotropin in normal equine pituitary and in pituitary tumors of horses with Cushing's disease. Endocrinology 111:559-563, 1982
25. Schott HC: Pituitary pars intermedia dysfunction: equine Cushing's disease. Vet Clin Equine 18:237-270, 2002
26. Scully KM, Rosenfeld MG: Pituitary development: regulatory codes in mammalian organogenesis. Science 295:2231-2235, 2002
27. Silberzahn P, Pouret EJ, Zwain I: Androgen and oestrogen response to a single injection of hCG in cryptorchid horses. Equine Vet J 21:126-129, 1989
28. Van der Kolk JH, Heinrichs M, Amerongen JD, Stooker RCJ, in de Wal LJ, van den Ingh TSGAM: Evaluation of pituitary gland anatomy and histopathologic findings in clinically normal horses and horses and ponies with pituitary pars intermedia adenoma. Am J Vet Res 65:1701-1707, 2004
29. Williams PJ, MacVicar BA, Pittman QJ: Synaptic modulation by dopamine of calcium currents in rat pars intermedia. J Neurosci 10:757-763, 1990
30. Wilson MG, Nicholson WE, Holscher MA, Sherrell BJ, Mount CD, Orth DN: Pro-opiolipomelanocortin peptides in normal pituitary, pituitary tumor, and plasma of normal and Cushing's horses. Endocrinology 110:941-954, 1982