Conformational changes below the Tm: Molecular dynamics studies of the thermal pretransition of ribonuclease A

Biochemistry

Volumn 47, Issue 3, 2008, Pages 880-892

  Merkley, Eric D ^a   Bernard, Brady ^b   Daggett, Valerie ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; ENZYME ACTIVITY; MELTING POINT; PROTEINS; THERMAL EFFECTS; TOPOLOGY;

BOVINE PANCREATIC RIBONUCLEASE; THERMAL PRETRANSITION;

MOLECULAR DYNAMICS;

DIMER; RIBONUCLEASE A; SOLVENT; PANCREATIC RIBONUCLEASE; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; HIGH TEMPERATURE; HYDROGEN BOND; MELTING POINT; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; SIMULATION; ALGORITHM; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; HEAT; HYDROPHOBICITY; PHASE TRANSITION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; TRANSITION TEMPERATURE;

BOVINAE;

ALGORITHMS; ANIMALS; CATALYTIC DOMAIN; CATTLE; COMPUTER SIMULATION; HEAT; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, MOLECULAR; PHASE TRANSITION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RIBONUCLEASE, PANCREATIC; TRANSITION TEMPERATURE; WATER;

EID: 38349166890     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701565b     Document Type: Article

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