Acid-related oesophageal sensitivity, not dysmotility, differentiates subgroups of patients with non-erosive reflux disease

Alimentary Pharmacology and Therapeutics

Volumn 27, Issue 5, 2008, Pages 396-403

  Thoua, N M ^a   Khoo, D ^b   Kalantzis, C ^a   Emmanuel, A V ^a  

^a UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCHLORIC ACID; SODIUM CHLORIDE;

ADULT; ARTICLE; CONTROLLED STUDY; ESOPHAGUS MOTILITY; ESOPHAGUS PAIN; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL ENDOSCOPY; HEARTBURN; HUMAN; HYPERSENSITIVITY; LOWER ESOPHAGUS SPHINCTER PRESSURE; MAJOR CLINICAL STUDY; MALE; NOCICEPTION; PAIN ASSESSMENT; PRIORITY JOURNAL; REFLUX ESOPHAGITIS; VISUAL ANALOG SCALE;

ADULT; CASE-CONTROL STUDIES; ESOPHAGEAL MOTILITY DISORDERS; ESOPHAGOSCOPY; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; HYDROCHLORIC ACID; HYDROGEN-ION CONCENTRATION; INFUSIONS, PARENTERAL; MALE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; SENSITIVITY AND SPECIFICITY; SODIUM CHLORIDE;

EID: 38349165306     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2007.03584.x     Document Type: Article

References (32)

1. Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2005 54 : 710 7.
2. Lind T, Havelund T, Carlsson R, et al. Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 1997 32 : 974 9.
3. Jones RH, Hungin ADS, Philips J, et al. Gastroesophageal reflux disease in primary care in Europe: clinical presentation and endoscopic findings. Eur J Gen Pract 1995 1 : 149 54.
4. Dent J, Brun J, Fendrick AM. An evidence-based appraisal of reflux disease management - the Genval Workshop Report. Gut 1999 44 (Suppl. 2 S1 16.
5. Carlsson R, Dent J, Watts R, et al. Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. International GORD Study Group. Eur J Gastroenterol Hepatol 1998 10 : 119 24.
6. Dean BB, Gano AD Jr., Knight K, Ofman JJ, Fass R. Effectiveness of proton pump inhibitors in nonerosive reflux disease. Clin Gastroenterol Hepatol 2004 2 : 656 64.
7. Shi G, Bruley des Varannes S, Scarpignato C, Le Rhun M, Galmiche JP. Reflux related symptoms in patients with normal oesophageal exposure to acid. Gut 1995 37 : 457 64.
8. Martinez SD, Malagon IB, Garewal HS, Cui H, Fass R. Non-erosive reflux disease (NERD) - acid reflux and symptom patterns. Aliment Pharmacol Ther 2003 17 : 537 45.
9. Galmiche JP, Clouse RE, Balint A, et al. Functional esophageal disorders. Gastroenterology 2006 130 : 1459 65.
10. Khajanchee YS, Hong D, Hansen PD, Swanström LL. Outcomes of antireflux surgery in patients with normal preoperative 24-hour pH test results. Am J Surg 2004 187 : 599 603.
11. Cicala M, Emerenziani S, Caviglia R, et al. Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2003 18 : 605 13.
12. Weusten BL, Akkermans LM, VanBerge-Henegouwen GP, Smout AJ. Symptom perception in gastroesophageal reflux disease is dependent on spatiotemporal reflux characteristics. Gastroenterology 1995 108 : 1739 44.
13. Kahrilas PJ, Dodds WJ, Hogan WJ. Effect of peristaltic dysfunction on esophageal volume clearance. Gastroenterology 1988 94 : 73 80.
14. Fass R. Erosive esophagitis and nonerosive reflux disease (NERD) - comparison of epidemiologic physiologic and therapeutic characteristics. J Clin Gastroenterol 2007 41 : 131 7.
15. Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995 37 : 7 12.
16. Sarkar S, Thompson DG, Woolf CJ, Hobson AR, Millane T, Aziz Q. Patients with chest pain and occult gastroesophageal reflux demonstrate visceral pain hypersensitivity which may be partially responsive to acid suppression. Am J Gastroenterol 2004 99 : 1998 2006.
17. Fass R, Naliboff B, Higa L, et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998 115 : 1363 73.
18. Shapiro M, Green C, Bautista JM, et al. Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acid. Am J Gastroenterol 2006 101 : 1084 91.
19. Clouse RE, Richter JE, Heading RC, Janssens J, Wilson JA. Functional esophageal disorders. Gut 1999 45 (Suppl. 2 ii31 6.
20. Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999 45 : 172 80.
21. Smout AJ. Endoscopy-negative acid reflux disease. Aliment Pharmacol Ther 1997 11 (Suppl. 2 81 5.
22. Miwa H, Minoo T, Hojo M, et al. Oesophageal hypersensitivity in Japanese patients with non-erosive gastro-oesophageal reflux diseases. Aliment Pharmacol Ther 2004 20 (Suppl. 1 112 7.
23. Marrero JM, de Caestecker JS, Maxwell JD. Effect of famotidine on oesophageal sensitivity in gastro-oesophageal reflux disease. Gut 1994 35 : 447 50.
24. Nagahara A, Miwa H, Minoo T, et al. Increased esophageal sensitivity to acid and saline in patients with nonerosive gastro-esophageal reflux disease. J Clin Gastroenterol 2006 40 : 891 5.
25. Stam R, Croiset G, Akkermans LM, Wiegant VM. Sensitization of the colonic response to novel stress after previous stressful experience. Am J Physiol 1996 271 : R1270 3.
26. Rao SS, Hatfield RA, Suls JM, Chamberlain MJ. Psychological and physical stress induces differential effects on human colonic motility. Am J Gastroenterol 1998 93 : 985 90.
27. Dickhaus B, Mayer EA, Firooz N, et al. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. Am J Gastroenterol 2003 98 : 135 43.
28. Bradley LA, Richter JE, Pulliam TJ, et al. The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors. Am J Gastroenterol 1993 88 : 11 9.
29. Fass R. Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease. Am J Gastroenterol 2003 98 (Suppl. 3 S2 7.
30. Frazzoni M, De Micheli E, Zentilin P, Savarino V. Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburn. Aliment Pharmacol Ther 2004 20 : 81 8.
31. Balaban DH, Yamamoto Y, Liu J, et al. Sustained esophageal contraction: a marker of esophageal chest pain identified by intraluminal ultrasonography. Gastroenterology 1999 116 : 29 37.
32. Pehlivanon N, Liu J, Mittal RK. Sustained esophageal contraction: a motor correlate of heartburn symptom. Am J Gastrointest Liver Physiol 2001 281 : G743 51.