Interaction of suplatast tosilate (IPD) with chloride channels in human blood eosinophils: A potential mechanism underlying its anti-allergic and anti-asthmatic effects

Clinical and Experimental Allergy

Volumn 38, Issue 2, 2008, Pages 305-312

  Agrawal, D K ^a   Cheng, G ^a   Kim, M J ^a   Kiniwa, M ^b  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Adhesion; Allergy; Asthma; Chemotaxis; Chloride channels; Eosinophils; IPD; Receptors; Respiratory burst; Suplatast tosilate

Indexed keywords

4 METHYLBENZOIC ACID; ANTIALLERGIC AGENT; ANTIASTHMATIC AGENT; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; RADIOLIGAND; SODIUM CHLORIDE; SULFONIC ACID DERIVATIVE; SUPEROXIDE; SUPLATAST TOSYLATE; TOLUENESULFONIC ACID; TRITIUM; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC ASTHMA; ARTICLE; BINDING ASSAY; BINDING SITE; BLOOD; BLOOD DONOR; CELL ADHESION; CHEMOTAXIS; CHLORIDE CURRENT; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTRIC POTENTIAL; ENDOTHELIUM CELL; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOLATION PROCEDURE; LIGAND BINDING; MALE; PATCH CLAMP; PRIORITY JOURNAL; RESPIRATORY BURST; WHOLE CELL;

ADULT; AGED; ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ARYLSULFONATES; ASTHMA; BINDING SITES; CELL ADHESION; CHEMOTAXIS; CHLORIDE CHANNELS; CHLORIDES; ENDOTHELIAL CELLS; EOSINOPHILS; FEMALE; HUMANS; MALE; MIDDLE AGED; RESPIRATORY BURST; RESPIRATORY HYPERSENSITIVITY; SULFONIUM COMPOUNDS;

EID: 38349153328     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2007.02877.x     Document Type: Article

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