Analysis of the exon 12 and 14 mutations of the JAK2 gene in Philadelphia chromosome-positive leukemia [11]

Leukemia

Volumn 22, Issue 1, 2008, Pages 216-

  Inami, M ^a   Yamaguchi, H ^a   Hasegawa, S ^b   Mitamura, Y ^a   Kosaka, F ^a   Kobayashi, A ^b   Kimura, S ^b   Dan, K ^a   Inokuchi, K ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Sekino Clinical Pharmacology Clinic   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BCR ABL PROTEIN; IMATINIB; JANUS KINASE 2; STAT PROTEIN; STAT5 PROTEIN;

BONE MARROW CELL; CANCER GENETICS; CHROMOSOME ABERRATION; CHRONIC MYELOID LEUKEMIA; DISEASE COURSE; DISEASE SEVERITY; EXON; GENE DELETION; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC IDENTIFICATION; GENETIC REGULATION; GENETIC STABILITY; HUMAN; LETTER; MAJOR CLINICAL STUDY; PHILADELPHIA 1 CHROMOSOME; POLYCYTHEMIA VERA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TELOMERE; UNITED STATES;

EID: 38349133620     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404953     Document Type: Letter

References (8)

1. Jelinek J, Oki Y, Gharibyan V, Bueso-Ramos C, Prchal JT, Verstovsek S et al. JAK2 mutation 1849G> T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 2005; 106: 3370-3373.
2. Kronenwett R, Graf T, Neumann F, Pechtel S, Steidl U, Diaz-Blanco E et al. Absence of the JAK2 mutation V617F in CD34+ hematopoietic stem and progenitor cells from patients with BCR-ABL-positive CML in chronic phase and blast crisis. Leuk Res 2006; 30: 1323-1324.
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8. Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 1996; 13: 247-254.