Nonfunctioning Pituitary Tumors and Pituitary Incidentalomas

Endocrinology and Metabolism Clinics of North America

Volumn 37, Issue 1, 2008, Pages 151-171

  Molitch, Mark E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; CABERGOLINE; DOPAMINE RECEPTOR STIMULATING AGENT; OCTREOTIDE;

AUTOPSY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; HYPERPITUITARISM; HYPOPHYSIS TUMOR; HYPOPITUITARISM; HYPOTHALAMUS DISEASE; INCIDENTAL FINDING; NONFUNCTIONING PITUITARY ADENOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PITUITARY INCIDENTALOMA; PRIORITY JOURNAL; REVIEW; TRANSSPHENOIDAL SURGERY; TUMOR DIAGNOSIS; TUMOR RECURRENCE; VISUAL FIELD DEFECT;

HUMANS; INCIDENTAL FINDINGS; MAGNETIC RESONANCE IMAGING; PITUITARY NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 38349103090     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecl.2007.10.011     Document Type: Review

References (127)

1. Young W.F., Scheithauer B.W., Kovacs K.T., et al. Gonadotroph adenoma of the pituitary gland: a clinicopathologic analysis of 100 cases. Mayo Clin Proc 71 (1996) 649-656
2. Yamada S., Kovacs K., Horvath E., et al. Morphological study of clinically nonsecreting pituitary adenomas in patients under 40 years of age. J Neurosurg 75 (1991) 902-905
3. Chambers E.F., Turski P.A., LaMasters D., et al. Regions of low density in the contrast-enhanced pituitary gland: normal and pathologic processes. Radiology 144 (1982) 109-113
4. Elster A.D. Modern imaging of the pituitary. Radiology 187 (1993) 1-14
5. Freda P.U., Wardlaw S.L., and Post K.D. Unusual causes of sellar/parasellar masses in a large transsphenoidal surgical series. J Clin Endocrinol Metab 81 (1996) 3455-3459
6. Naidich M.J., and Russell E.J. Current approaches to imaging of the sellar region and pituitary. Endocrinol Metab Clin North Am 28 (1999) 45-79
7. Powrie J.K., Powell M., Ayers A.B., et al. Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. Clin Endocrinol 42 (1995) 315-322
8. Doraiswamy P.M., Potts J.M., Axelson D.A., et al. MR assessment of pituitary gland morphology in healthy volunteers: age- and gender-related differences. Am J Neuroradiol 13 (1992) 1295-1299
9. Elster A.D., Chen M.Y., Williams D.W.D., et al. Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology 174 (1999) 681-685
10. Tsunoda A., Okuda O., and Sato K. MR height of the pituitary gland as a function of age and sex: especially physiological hypertrophy in adolescence and in climacterium. Am J Neuroradiol 18 (1997) 551-554
11. Chanson P., Daujat F., Young J., et al. Normal pituitary hypertrophy as a frequent cause of pituitary incidentalomas: a follow-up study. J Clin Endocrinol Metab 86 (2001) 3009-3015
12. Susman W. Pituitary adenoma. Br Med J 2 (1933) 1215
13. Close H.G. The incidence of adenoma of the pituitary body in some types of new growth. Lancet 1 (1934) 732-734
14. Costello R.T. Subclinical adenoma of the pituitary gland. Am J Pathol 12 (1936) 205-215
15. Sommers S.C. Pituitary cell relations to body states. Lab Invest 8 (1959) 588-621
16. McCormick W.F., and Halmi N.S. Absence of chromophobe adenomas from a large series of pituitary tumors. Arch Pathol 92 (1971) 231-238
17. Haugen O.A. Pituitary adenomas and the histology of the prostate in elderly men. Acta Path Microbiol Scand Section A 81 (1973) 425-434
18. Kovacs K., Ryan N., and Horvath E. Pituitary adenomas in old age. J Gerontol 35 (1980) 16-22
19. Landolt A.M. Biology of pituitary microadenomas. In: Faglia G., Giovanelli M.A., and MacLeod R.M. (Eds). Pituitary microadenomas (1980), Academic Press, New York 107-122
20. Mosca L., Solcia E., Capella C., et al. Pituitary adenomas: surgical versus post-mortem findings today. In: Faglia G., Giovanelli M.A., and MacLeod R.M. (Eds). Pituitary microadenomas (1980), Academic Press, New York 137-142
21. Burrows G.N., Wortzman G., Rewcastle N.B., et al. Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med 304 (1981) 156-158
22. Parent A.D., Bebin J., and Smith R.R. Incidental pituitary adenomas. J Neurosurg 54 (1981) 228-231
23. Muhr C., Bergstrom K., Grimelius L., et al. A parallel study of the roentgen anatomy of the sella turcica and the histopathology of the pituitary gland in 205 autopsy specimens. Neuroradiology 21 (1981) 55-65
24. Max M.B., Deck M.D.F., and Rottenberg D.A. Pituitary metastasis: incidence in cancer patients and clinical differentiation from pituitary adenoma. Neurology 31 (1981) 998-1002
25. Schwezinger G., and Warzok R. Hyperplasien und adenome der hypophyse im unselektierten sektionsgut. Zentralbi Allg Pathol 126 (1982) 495-498
26. Coulon G., Fellmann D., Arbez-Gindre F., et al. Les adenome hypophysaires latents. Etude autopsique. Sem Hop Paris 59 (1983) 2747-2750
27. Siqueira M.G., and Guembarovski A.L. Subclinical pituitary microadenomas. Surg Neurol 22 (1984) 134-140
28. Char G., and Persaud V. Asymptomatic microadenomas of the pituitary gland in an unselected autopsy series. West Indian Med J 35 (1986) 275-279
29. Gorczyca W., and Hardy J. Microadenomas of the human pituitary and their vascularization. Neurosurgery 22 (1988) 1-6
30. El-Hamid M.W.A., Joplin G.F., and Lewis P.D. Incidentally found small pituitary adenomas may have no effect on fertility. Acta Endocrinol 117 (1988) 361-364
31. Scheithauer B.W., Kovacs K.T., Randall R.V., et al. Effects of estrogen on the human pituitary: a clinicopathologic study. Mayo Clin Proc 64 (1989) 1077-1084
32. Kontogeorgos G., Kovacs K., Horvath E., et al. Multiple adenomas of the human pituitary. A retrospective autopsy study with clinical implications. J Neurosurg 74 (1991) 243-247
33. Marin F., Kovacs K.T., Scheithauer B.W., et al. The pituitary gland in patients with breast carcinoma: a histologic and immunocytochemical study of 125 cases. Mayo Clin Proc 67 (1992) 949-956
34. Sano T., Kovacs K.T., Scheithauer B.W., et al. Aging and the human pituitary gland. Mayo Clin Proc 68 (1993) 971-977
35. Teramoto A., Hirakawa K., Sanno N., et al. Incidental pituitary lesions in 1,000 unselected autopsy specimens. Radiology 193 (1994) 161-164
36. Camaris C., Balleine R., and Little D. Microadenomas of the human pituitary. Pathology 27 (1995) 8-11
37. Tomita T., and Gates E. Pituitary adenomas and granular cell tumors. Incidence, cell type, and location of tumor in 100 pituitary glands at autopsy. Am J Clin Pathol 111 (1999) 817-825
38. Kurosaki M., Saeger W., and Lüdecke D.K. Pituitary tumors in the elderly. Pathol Res Pract 197 (2001) 493-497
39. Buurman H., and Saeger W. Subclinical adenomas in postmortem pituitaries: classification and correlations to clinical data. Eur J Endocrinol 154 (2006) 753-758
40. Rittierodt M., and Hori A. Pre-morbid morphological conditions of the human pituitary. Neuropathology 27 (2007) 43-48
41. Auer R.N., Alakija P., and Sutherland G.R. Asymptomatic large pituitary adenomas discovered at autopsy. Surg Neurol 46 (1996) 28-31
42. Wolpert S.M., Molitch M.E., Goldman J.A., et al. Size, shape and appearance of the normal female pituitary gland. Am J Neuroradiol 5 (1984) 263-267
43. Peyster R.G., Adler L.P., Viscarello R.R., et al. CT of the normal pituitary gland. Neuroradiology 28 (1986) 161-165
44. Chong B.W., Kucharczyk A.W., Singer W., et al. Pituitary gland MR: a comparative study of healthy volunteers and patients with microadenomas. Am J Neuroradiol 15 (1994) 675-679
45. Hall W.A., Luciano M.G., Doppman J.L., et al. Pituitary magnetic resonance imaging in normal human volunteers: occult adenomas in the general population. Ann Intern Med 120 (1994) 817-820
46. Nammour G.M., Ybarra J., Naheedy M.H., et al. Incidental pituitary macroadenoma: a population-based study. Am J Med Sci 314 (1997) 287-291
47. Yue N.C., Longsteth Jr. W.T., Elster A.D., et al. Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the Cardiovascular Health Study. Radiology 202 (1997) 41-46
48. Chacko A.G., and Chandy M.J. Incidental pituitary macroadenomas. Br J Neurosurg 6 (1992) 233-236
49. Donovan L.E., and Corenblum B. The natural history of the pituitary incidentaloma. Arch Intern Med 153 (1995) 181-183
50. Reincke M., Allolio B., Saeger W., et al. The 'incidentaloma' of the pituitary gland. Is neurosurgery required?. JAMA 263 (1990) 2772-2776
51. Nishizawa S., Ohta S., Yokoyama T., et al. Therapeutic strategy for incidentally found pituitary tumors ("pituitary incidentalomas"). Neurosurgery 43 (1998) 1344-1348
52. Feldkamp J., Santen R., Harms E., et al. Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomas-results of a prospective study. Clin Endocrinol 51 (1999) 109-113
53. Igarashi T., Saeki N., and Yamaura A. Long-term magnetic resonance imaging follow-up of asymptomatic sellar tumors. Their natural history and surgical indications. Neurol Med Chir (Tokyo) 39 (1999) 592-599
54. Sanno N., Oyama K., Tahara S., et al. A survey of pituitary incidentaloma in Japan. Eur J Endocrinol 149 (2003) 123-127
55. Fainstein Day P., Guitelman M., Artese R., et al. Retrospective multicentric study of pituitary incidentalomas. Pituitary 7 (2004) 145-148
56. Arita K., Tominaga A., Sugiyama K., et al. Natural course of incidentally found nonfunctioning pituitary adenoma, with special reference to pituitary apoplexy during follow-up examination. J Neurosurg 104 (2006) 884-891
57. Angeli A., and Terzolo M. Adrenal incidentaloma-a modern disease with old complications. J Clin Endocrinol Metab 87 (2002) 4869-4871
58. Bradley K.J., Wass J.A.H., and Turner H.E. Non-functioning pituitary adenomas with positive immunoreactivity for ACTH behave more aggressively than ACTH immunonegative tumours but do not recur more frequently. Clin Endocrinol 58 (2003) 59-64
59. Lopez J.A., Kleinschmidt-DeMasters B.K., Sze C.-I., et al. Silent corticotroph adenomas: further clinical and pathological observations. Hum Pathol 35 (2004) 1137-1147
60. King Jr. J.T., Justice A.C., and Aron D.C. Management of incidental pituitary microadenomas: a cost-effectiveness analysis. J Clin Endocrinol Metab 82 (1997) 3625-3632
61. Krikorian A., and Aron D. Evaluation and management of pituitary incidentalomas-revisiting an acquaintance. Nat Clin Pract Endocrinol Metab 2 (2006) 138-145
62. Molitch M.E., and Reichlin S. Hypothalamic hyperprolactinemia: neuroendocrine regulation of prolactin secretion in patients with lesions of the hypothalamus and pituitary stalk. In: MacLeod R.M., Thorner M.O., and Scapagnini U. (Eds). Prolactin. Basic and clinical correlates (1985), Liviana Press, Padova (Italy) 709-719
63. Arafah M.B., Neki K.E., Gold R.S., et al. Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. J Clin Endocrinol Metab 80 (1995) 3507-3512
64. St-Jean E., Blain F., and Comtois R. High prolactin levels may be missed by immunoradiometric assay in patients with macroprolactinomas. Clin Endocrinol 44 (1996) 305-309
65. Barkan A.L., and Chandler W.F. Giant pituitary prolactinoma with falsely low serum prolactin: the pitfall of the "high-dose hook effect": case report. Neurosurgery 42 (1998) 913-915
66. The Growth Hormone Research Society and Pituitary Society Consensus Conference. Biochemical assessment and long-term monitoring in patients with acromegaly. J Clin Endocrinol Metab 89 (2004) 3099-102
67. Arnaldi G., Angeli A., Atkinson A.B., et al. Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 88 (2003) 5593-5602
68. Findling J.W., and Raff H. Cushing's syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab 91 (2006) 3746-3753
69. Erlichman C., Meakin J.W., and Simpson W.J. Review of 154 patients with non-functioning pituitary tumors. Int J Radiat Oncol Biol Phys 5 (1979) 1981-1986
70. Ebersold M.J., Quast L.M., Laws E.R., et al. Long-term results in transsphenoidal removal of nonfunctioning pituitary adenomas. J Neurosurg 64 (1986) 713-719
71. Comtois R., Beauregard H., Somma M., et al. The clinical and endocrine outcome to transsphenoidal microsurgery of nonsecreting pituitary adenomas. Cancer 68 (1991) 860-866
72. Shone G.R., Richards S.H., Hourihan M.D., et al. Non-secretory adenomas of the pituitary treated by trans-ethmoidal sellotomy. J R Soc Med 84 (1991) 140-143
73. Colao A., Cerbone G., Cappabianca P., et al. Effect of surgery and radiotherapy on visual and endocrine function in nonfunctioning pituitary adenomas. J Endocrinol Invest 21 (1998) 284-290
74. Greenman Y., Ouaknine G., Veshchev I., et al. Postoperative surveillance of clinically nonfunctioning pituitary macroadenomas: markers of tumour quiescence and regrowth. Clin Endocrinol 58 (2003) 763-769
75. Nomikos P., Ladar C., Fahlbusch R., et al. Impact of primary surgery on pituitary function in patients with non-functioning pituitary adenomas-a study on 721 patients. Acta Neurochir (Wien) 146 (2004) 27-35
76. Mortini P., Losa M., Barzaghi R., et al. Results of transsphenoidal surgery in a large series of patients with pituitary adenoma. Neurosurgery 56 (2005) 1222-1233
77. Arafah A.M. Reversible hypopituitarism in patients with large nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 62 (1986) 1173-1179
78. Tominaga A., Uozumi T., Arita K., et al. Anterior pituitary function in patients with nonfunctioning pituitary adenoma: results of longitudinal follow-up. Endocr J 42 (1995) 421-427
79. Dekkers O.M., Pereira A.M., Roelfsema F., et al. Observation alone after transsphenoidal surgery for nonfunctioning pituitary macroadenoma. J Clin Endocrinol Metab 91 (2006) 1796-1801
80. Marzuela M., Astigarraga B., Vicente A., et al. Recovery of visual and endocrine function following transsphenoidal surgery of large nonfunctioning pituitary adenomas. J Endocrinol Invest 17 (1994) 703-707
81. Molitch M.E., Clemmons D.R., Malozowski S., et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 91 (2006) 1621-1634
82. De Herder W.W., Kwekkeboom D.J., Feelders R.A., et al. Somatostatin receptor imaging for neuroendocrine tumors. Pituitary 9 (2006) 243-248
83. De Herder W.W., Reijs A.E., Feelders R.A., et al. Diagnostic imaging of dopamine receptors in pituitary adenomas. Eur J Endocrinol 156 Suppl 1 (2007) S53-S56
84. 18F]fluoro-ethyl-spiperone. Eur J Nucl Med 24 (1997) 1149-1155
85. Steiner E., Knosp E., Herold C.J., et al. Pituitary adenomas: findings of postoperative MR imaging. Radiology 185 (1992) 521-527
86. Dina T.S., Feaster S.H., and Laws E.R. MR of the pituitary gland postsurgery: serial MR studies following transsphenoidal resection. Am J Neuroradiol 14 (1993) 763-769
87. Ciric I., Ragin A., Baumgartner C., et al. Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery 40 (1997) 225-236
88. Barker II F.G., Klibanski A., and Swearingen B. Transsphenoidal surgery for pituitary tumors in the United States, 1996-2000; mortality, morbidity, and the effects of hospital and surgeon volume. J Clin Endocrinol Metab 88 (2003) 4709-4719
89. Nemergut E.C., Zuo Z., Jane J.A., et al. Predictors of diabetes insipidus after transsphenoidal surgery: a review of 881 patients. J Neurosurg 103 (2005) 448-454
90. Ciric I., Mikhael M., Stafford T., et al. Transsphenoidal microsurgery of pituitary macroadenomas with long-term follow-up results. J Neurosurg 59 (1983) 395-401
91. Pia H.W., Grote E., and Hildebrandt G. Giant pituitary adenomas. Neurosurg Rev 8 (1985) 207-220
92. Mohr G., Hardy J., Comtois R., et al. Surgical management of giant pituitary adenomas. Can J Neurol Sci 17 (1990) 62-66
93. Alleyne Jr. C.H., Barrow D.L., and Oyesiku N.M. Combined transsphenoidal and pterional craniotomy approach to giant pituitary tumors. Surg Neurol 57 (2002) 380-390
94. Bradley K.M., Adams C.B.T., Potter C.P.S., et al. An audit of selected patients with non-functioning pituitary adenoma treated by transsphenoidal surgery without irradiation. Clin Endocrinol 41 (1994) 655-659
95. Gittoes N.J.L., Bates A.S., Tse W., et al. Radiotherapy for non-functioning pituitary tumours. Clin Endocrinol 48 (1998) 331-337
96. Park P., Chandler W.F., Barkan A.L., et al. The role of radiation therapy after surgical resection of nonfunctional pituitary macroadenomas. Neurosurgery 55 (2004) 100-107
97. Brada M., Rajan B., Traish D., et al. The long-term efficacy of conservative surgery and radiotherapy in the control of pituitary adenomas. Clin Endocrinol 38 (1993) 571-578
98. Breen P., Flickinger J.C., Kondziolka D., et al. Radiotherapy for nonfunctional pituitary adenoma: analysis of long-term tumor control. J Neurosurg 89 (1998) 933-938
99. Lillehei K.O., Kirschman D.L., Kleinschmidt-DeMasters B.K., et al. Reassessment of the role of radiation therapy in the treatment of endocrine-inactive pituitary macroadenomas. Neurosurgery 43 (1998) 432-439
100. Turner H.E., Stratton I.M., Byrne J.V., et al. Audit of selected patients with nonfunctioning pituitary adenomas treated without irradiation-a follow-up study. Clin Endocrinol 51 (1999) 281-4
101. Woollons A.C., Hunn M.K., Rajapakse Y.R., et al. Non-functioning pituitary adenomas: indications for postoperative radiotherapy. Clin Endocrinol 53 (2000) 713-717
102. Soto-Ares G., Cortet-Rudelli C., Assaker R., et al. MRI protocol technique in the optimal therapeutic strategy of non-functioning pituitary adenomas. Eur J Endocrinol 146 (2002) 179-186
103. Alameda C., Lucas T., Peneda E., et al. Experience in the management of 51 non-functioning pituitary adenomas: indications for post-operative radiotherapy. J Endocrinol Invest 23 (2005) 18-22
104. Tanaka Y., Hongo K., Tada T., et al. Growth pattern and rate in residual nonfunctioning pituitary adenomas: correlations among tumor volume doubling time, patient age, and MIB-1 index. J Neurosurg 98 (2003) 359-365
105. Hansen L.K., and Molitch M.E. Postoperative radiotherapy for clinically nonfunctioning pituitary adenomas. Endocrinologist 8 (1998) 71-78
106. Gittoes N.J.L. Radiotherapy for non-functioning pituitary tumors-when and under what circumstances. Pituitary 6 (2003) 103-108
107. Sheehan J.P., Niranjan A., Sheehan J.M., et al. Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium. J Neurosurg 102 (2005) 678-691
108. Feigl G.C., Bonelli C.M., Berghold A., et al. Effects of gamma knife radiosurgery of pituitary adenomas on pituitary function. J Neurosurg 97 Suppl 5 (2002) 415-421
109. Tishler R.B., Loeffler J.S., Lunsford L.D., et al. Tolerance of cranial nerves of the cavernous sinus to radiosurgery. Int J Radiat Oncol Biol Phys 27 (1993) 215-221
110. Leber K.A., Berglöff J., and Pendl G. Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery. J Neurosurg 88 (1998) 43-50
111. St. George E.J., Kudhail J., Perks J., et al. Acute symptoms after gamma knife radiosurgery. J Neurosurg 97 Suppl 5 (2002) 631-634
112. Benveniste R.J., King W.A., Walsh J., et al. Repeated transsphenoidal surgery to treat recurrent or residual pituitary adenoma. J Neurosurg 102 (2005) 1004-1012
113. Swords F.M., Allan C.A., Plowman P.N., et al. Stereotactic radiosurgery SVI: a treatment for previously irradiated pituitary adenomas. J Clin Endocrinol Metab 88 (2003) 6334-40
114. Bevan J.S., and Burke C.W. Non-functioning pituitary adenomas do not regress during bromocriptine therapy but possess membrane-bound dopamine receptors which bind bromocriptine. Clin Endocrinol 25 (1986) 561-572
115. Pivonello R., Matrone C., Filippella M., et al. Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors: comparison with the effectiveness of cabergoline treatment. J Clin Endocrinol Metab 89 (2004) 1674-1683
116. Grossman A., Ross R., Charlesworth M., et al. The effect of dopamine agonist therapy on large functionless pituitary tumours. Clin Endocrinol 22 (1985) 679-686
117. Van Schaardenburg D., Roelfsema F., Van Seters A.P., et al. Bromocriptine therapy for non-functioning pituitary adenoma. Clin Endocrinol 30 (1989) 475-484
118. Greenman Y., Tordjman K., Osher E., et al. Postoperative treatment of clinically nonfunctioning pituitary adenomas with dopamine agonists decreases tumor remnant growth. Clin Endocrinol 63 (2005) 39-44
119. Lohmann T., Trantakis C., Biesold M., et al. Minor tumour shrinkage in nonfunctioning pituitary adenomas by long-term treatment with the dopamine agonist cabergoline. Pituitary 4 (2001) 173-178
120. Schade R., Andersohn F., Suissa S., et al. Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med 356 (2007) 29-38
121. Zanettini R., Antonini A., Gatto G., et al. Valvular heart disease and the use of dopamine agonists for Parkinson's disease. N Engl J Med 356 (2007) 39-46
122. De Bruin T.W.A., Kwekkeboom D.J., Van't Verlaat J.W., et al. Clinically nonfunctioning pituitary adenoma and octreotide response to long term high dose treatment, and studies in vitro. J Clin Endocrinol Metab 75 (1992) 1310-1317
123. Katznelson L., Oppenheim D.S., Coughlin J.F., et al. Chronic somatostatin analog administration in patients with α-subunit-secreting pituitary tumors. J Clin Endocrinol Metab 75 (1992) 1318-1325
124. Duet M., Mundler O., Ajzenberg C., et al. Somatostatin receptor imaging in non-functioning pituitary adenomas: value of an uptake index. Eur J Nucl Med 21 (1994) 647-650
125. Plockinger U., Reichel M., Fett U., et al. Preoperative octreotide treatment of growth hormone-secreting and clinically nonfunctioning pituitary macroadenomas: effect on tumor volume and lack of correlation with immunohistochemistry and somatostatin receptor scintigraphy. J Clin Endocrinol Metab 79 (1994) 1416-1423
126. Warnet A., Harris A.G., Renard E., et al. A prospective multicenter trial of octreotide in 24 patients with visual defects caused by nonfunctioning and gonadotropin-secreting pituitary adenomas. Neurosurgery 41 (1997) 786-796
127. Andersen M., Bjerre P., Schrøder H.D., et al. In vivo secretory potential and the effect of combination therapy with octreotide and cabergoline in patients with clinically non-functioning pituitary adenomas. Clin Endocrinol 56 (2001) 23-30