Gram-negative pathogen Klebsiella oxytoca is associated with spontaneous chronic otitis media in Toll-like receptor 4-deficient C3H/HeJ mice

Acta Oto-Laryngologica

Volumn 128, Issue 2, 2008, Pages 132-138

  MacArthur, Carol J ^a   Pillers, De Ann M ^b   Pang, Jiaqing ^b   Degagne, Jacqueline M ^a   Kempton, J Beth ^a   Trune, Dennis R ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Genetic animal models; Gram negative infections; Inflammation; Inner ear; Otitis media

Indexed keywords

ENDOTOXIN; TOLL LIKE RECEPTOR 4;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BLOOD CULTURE; C3H MOUSE; CHRONIC OTITIS MEDIA; CONTROLLED STUDY; DISEASE MODEL; ELECTRON MICROSCOPY; HISTOPATHOLOGY; IMAGE ANALYSIS; INFLAMMATION; INNATE IMMUNITY; KLEBSIELLA OXYTOCA; MOUSE; MYRINGOTOMY; NEUTROPHIL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; BACTERIOLOGICAL TECHNIQUES; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; EAR, MIDDLE; IMMUNE TOLERANCE; IMMUNITY, NATURAL; KLEBSIELLA INFECTIONS; KLEBSIELLA OXYTOCA; MICE; MICE, INBRED C3H; MICROSCOPY, ELECTRON; OTITIS MEDIA; OTOSCOPY; POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 4;

EID: 38349077402     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480701387124     Document Type: Article

References (20)

1. AHQR. Management of acute otitis media. Summary, evidence report/technology assessment. No. 15, June 2000. http:/www.ahqr.gov/clinic/ otitisum.htm
2. Mitchell C, Kempton JB, Scott-Tyler DR, Trune DR. Otitis media incidence and impact on the ABR in lipopolysaccharide-nonresponsive C3H/HeJ mice. Otolaryngol Head Neck Surg 1997;117:459-64.
3. Qureshi S, Lariviere L, Leveque G, Clermont S, Moore KJ, Gros P, et al. Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4). J Exp Med 1999;189:615-25.
4. Haziot A, Hijiya N, Gangloff SC, Silver J, Goyert SM. Induction of a novel mechanism of accelerated bacterial clearance by lipopolysaccaride in CD14-deficient and toll-like receptor 4-deficient mice. J Immunol 2001;166:1075-8.
5. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/HeJ and C57/10ScCr mice: mutations in Tlr4 gene. Science 1998;282:2085-8.
6. MacArthur CJ, Hefeneider S, Kempton JB, Trune DR. C3H/HeJ mouse model for spontaneous chronic otitis media. Laryngoscope 2006;116:1071-9.
7. Kovtunovych G, Lytvynenko T, Negrutska V, Lar O, Brisse S, Kozyrovska N. Identification of Klebsiella oxytoca using a specific PCR assay targeting the polygalacturonase pehX gene. Res Microbiol 2003;154:587-92.
8. Inglis A, Gates G. Acute otitis media and otitis media with effusion. In: Cummings C, editor. Cummings otolaryngology head & neck surgery. Philadelphia: Elsevier; 2005. p. 4445-68.
9. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000;25:187-91.
10. Sahly H, Podschun R. Clinical, bacteriological, and serological aspects of Klebsiella infection and their spondylarthropathic sequelae. Clin Diagn Lab Immunol 1997;4:393-9.
11. Podschun R, Ullman U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 1998;11:589-603.
12. Orobello P, Park R, Belcher LJ, Eggleston P, Lederman HM, Banks JR, et al. Microbiology of chronic sinusitis in children. Arch Otolaryngol Head Neck Surg 1991;117:980-3.
13. Gray J, Hobbs P. Management of outbreaks of Gram-negative bacteria in neonatal units. J Hosp Infect 2002;52:317-8.
14. Lorenz E, Hallman M, Marttila R, Haataja R, Schwartz DA. Association between the Asp299Gly polymorphisms in the toll-like receptor 4 and premature births in the Finnish population. J Pediatr Res 2002;52:373-6.
15. Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol 2004;5:975-9.
16. Hoag WG, Meier H. Infectious diseases. In: Green EL, editor. Biology of the laboratory mouse. New York: Dover Publications; 1966. p. 595-6.
17. Amako K, Meno Y, Takade A. Fine structures of the capsules of Klebsiella pneumoniae and Escherichia coli K1. J Bacteriol 1988;170:4960-2.
18. Meyerhoff WL, Kim CS, Paparella MM. Pathology of chronic otitis media. Ann Otol Rhinol Laryngol 1978;87:1-12.
19. Schachern P, Paparella M, Hybertson R, Sano S, Duvall AJ. Bacterial tympanogenic labyrinthitis, meningitis and sensorineural damage. Arch Otolaryngol Head Neck Surg 1992;118:53-7.
20. Cureoglu S, Schachern PA, Paparella MM, Lindgren BR. Cochlear changes in chronic otitis media. Laryngoscope 2004;114:622-6.