Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity

Biochemical and Biophysical Research Communications

Volumn 367, Issue 2, 2008, Pages 497-502

  Qian, Weizhu ^a,b   Wang, Ling ^a   Li, Bohua ^a,b   Wang, Hao ^a,b   Hou, Sheng ^a,b   Hong, Xueyu ^a   Zhang, Dapeng ^a   Guo, Yajun ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Shanghai Center for Cell Engineering and Antibody   (China)

Author keywords

CD34; Chimeric antibody; Hematopoietic stem cells; Immunogenicity; Monoclonal antibody

Indexed keywords

CD34 ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ARTICLE; CHIMERA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOGENICITY; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD34; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MICE; MICE, INBRED BALB C; PROTEIN ENGINEERING;

MURINAE;

EID: 38349076949     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.184     Document Type: Article

References (18)

1. Bhattacharya A., Slatter M.A., Chapman C.E., Barge D., Jackson A., Flood T.J., Abinun M., Cant A.J., and Gennery A.R. Single centre experience of umbilical cord stem cell transplantation for primary immunodeficiency. Bone Marrow Transplant. 36 (2005) 295-299
2. Peters C., and Steward C.G. Hematopoietic cell transplantation for inherited metabolic diseases: an overview of outcomes and practice guidelines. Bone Marrow Transplant. 31 (2003) 229-239
3. Kekarainen T., Mannelin S., Laine J., and Jaatinen T. Optimization of immunomagnetic separation for cord blood-derived hematopoietic stem cells. BMC Cell Biol. 7 (2006) 30
4. Civin C.I. Human monomyeloid cell membrane antigens. Exp. Hematol. 18 (1990) 461-467
5. He X.Y., Antao V.P., Basila D., Marx J.C., and Davis B.R. Isolation and molecular characterization of the human CD34 gene. Blood 79 (1992) 2296-2302
6. Civin C.I., Strauss L.C., Brovall C., Fackler M.J., Schwartz J.F., and Shaper J.H. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J. Immunol. 133 (1984) 157-165
7. Sutherland D.R., Marsh J.C., Davidson J., Baker M.A., Keating A., and Mellors A. Differential sensitivity of CD34 epitopes to cleavage by Pasteurella haemolytica glycoprotease: implications for purification of CD34-positive progenitor cells. Exp. Hematol. 20 (1992) 590-599
8. Steen R., Tjønnfjord G.E., Gaudernack G., Brinch L., and Egeland T. Differences in the distribution of CD34 epitopes on normal haemopoietic progenitor cells and leukaemic blast cells. Br. J. Haematol. 94 (1996) 597-605
9. Otto M., Chen X., Martin W.J., Leung W., Knowles J., Holladay M., Houston J., Handgretinger R., and Barfield R.C. Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation. Stem Cells 25 (2007) 537-542
10. Morrison S.L., Johnson M.J., Herzenberg L.A., and Oi V.T. Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. USA 81 (1984) 6851-6855
11. Boulianne G.L., Hozumi N., and Shulman M.J. Production of functional chimaeric mouse/human antibody. Nature 312 (1984) 643-646
12. Kipriyanov S.M., and Little M. Generation of recombinant antibodies. Mol. Biotechnol. 12 (1999) 173-201
13. LoBuglio A.F., Wheeler R.H., Trang J., Haynes A., Rogers K., Harvey E.B., Sun L., Ghrayeb J., and Khazaeli M.B. Mouse/human chimeric monoclonal antibody in man: kinetics and immune response. Proc. Natl. Acad. Sci. USA 86 (1989) 4220-4224
14. Coloma M.J., Hastings A., Wims L.A., and Morrison S.L. Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction. J. Immunol. Methods 152 (1992) 89-104
15. Li B., Wang H., Dai J., Ji J., Qian W., Zhang D., Hou S., and Guo Y. Construction and characterization of a humanized anti-human CD3 monoclonal antibody 12F6 with effective immunoregulation functions. Immunology 116 (2005) 487-498
16. Köhler G., and Milstein C. Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur. J. Immunol. 6 (1976) 511-519
17. Kabat E.A., Wu T.T., Perry H.M., Gottesman K.S., and Foeller C. Sequences of Proteins of Immunological Interest. fifth ed. (1991), United States Department of Health and Human Services, Bethesda, MD
18. Krause D.S., Fackler M.J., Civin C.I., and May W.S. CD34: structure, biology, and clinical utility. Blood 87 (1996) 1-13