Abnormal bone and mineral metabolism in kidney transplant patients - A review

American Journal of Nephrology

Volumn 28, Issue 2, 2008, Pages 246-253

  Sprague, Stuart M ^a   Belozeroff, Vasily ^b   Danese, Mark D ^c   Martin, Lynn P ^c   Olgaard, Klaus ^d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b AMGEN INC   (United States)

^c Outcomes Insights Inc   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Bone disease, post transplant; Hyperparathyroidism, secondary; Kidney transplant; Mineral metabolism

Indexed keywords

CALCIUM; PARATHYROID HORMONE; PHOSPHORUS; VITAMIN D;

BONE DENSITY; BONE METABOLISM; DISEASE SEVERITY; HUMAN; HYPERTENSION; HYPERTHYROIDISM; HYPOPHOSPHATEMIA; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; METABOLIC DISORDER; MINERAL METABOLISM; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME;

BIOLOGICAL MARKERS; BONE AND BONES; CALCIUM; DISEASE PROGRESSION; HUMANS; HYPERPARATHYROIDISM, SECONDARY; KIDNEY; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; PHOSPHORUS; TIME FACTORS; TREATMENT OUTCOME; VITAMIN D;

EID: 38349071130     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000110875     Document Type: Review

References (58)

1. Cecka JM, Terasaki PI: Worldwide transplant center directory;in Cecka JM, Terasaki PI (eds): Clinical Transplants 2002. Los Angeles, UCLA Immunogenetics Center, 2003, pp 417-546.
2. Vazquez MA: Chronic rejection of renal transplants: new clinical insights. Am J Med Sci 2000;320:43-58.
3. De Boer IH, Gorodetskaya I, Young B, Hsu CY, Chertow GM: The severity of secondary hyperparathyroidism in chronic renal insufficiency is GFR-dependent, race-dependent, and associated with cardiovascular disease. J Am Soc Nephrol 2002;13:2762-2769.
4. Cunningham J, Danese M, Olson K, Klassen P, Chertow GM: Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism. Kidney Int 2005;68:1793-1800.
5. Teng M, Wolf M, Ofsthun MN, Lazarus JM, Hernan MA, Camargo CA Jr, Thadhani R: Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol 2005;16:1115-1125.
6. Rix M, Lewin E, Olgaard K: Post-transplant bone disease. Transplant Rev 2003;17:176-186.
7. Torres A, Lorenzo V, Salido E: Calcium metabolism and skeletal problems after transplantation. J Am Soc Nephrol 2002;13:551-558.
8. Moe S, Drueke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G: Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006;69:1945-1953.
9. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease. National Kidney Foundation/Disease Outcome Quality Initiative. Am J Kidney Dis 2003;42(suppl 3):S1-S201.
10. Bonnin MR, Gonzalez MT, Grino JM, Cruzado JM, Bover J, Martinez JM, Navarro MA: Changes in serum osteocalcin levels in the follow-up of kidney transplantation. Ann Clin Biochem 1997;34:651-655.
11. Claesson K, Hellman P, Frodin L, Rastad J: Prospective study of calcium homeostasis after renal transplantation. World J Surg 1998;22:635-641.
12. de Sevaux RG, Hoitsma AJ, van Hoof HJ, Corstens FJ, Wetzels JF: Abnormal vitamin D metabolism and loss of bone mass after renal transplantation. Nephron Clin Pract 2003;93:C21-C28.
13. Gonzalez MT, Bonnin R, Cruzado JM, Garcia R, Moreso F, Fulladosa X, Alsina J, Navarro MA, Grino JM: Course of three biochemical bone markers after kidney transplantation. Transplant Proc 1995;27:2266-2271.
14. Messa P, Sindici C, Cannella G, Miotti V, Risaliti A, Gropuzzo M, Di Loreto PL, Bresadola F, Mioni G: Persistent secondary hyperparathyroidism after renal transplantation. Kidney Int 1998;54:1704-1713.
15. Mikuls TR, Julian BA, Bartolucci A, Saag KG: Bone mineral density changes within six months of renal transplantation. Transplantation 2003;75:49-54.
16. Oschatz E, Benesch T, Kodras K, Hoffmann U, Haas M: Changes of coronary calcification after kidney transplantation. Am J Kidney Dis 2006;48:307-313.
17. Saha HH, Salmela KT, Ahonen PJ, Pietila KO, Morsky PJ, Mustonen JT, Lalla ML, Pasternack AI: Sequential changes in vitamin D and calcium metabolism after successful renal transplantation. Scand J Urol Nephrol 1994;28:21-27.
18. Soylemezoglu O, Derici U, Arinsoy T, Hasanoglu A, Ozkaya O, Dalgic A, Bideci A, Buyan N, Hasanoglu E: Changes in bone mineral density, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in kidney transplant recipients. A longitudinal study. Nephron 2002;91:468-473.
19. Suwelack B, Gerhardt U, Witta J, Hillebrandt U, Hohage H: Effect of parathyroid hormone levels on carotid intima-media thickness after renal transplantation. Am J Hypertens 2001;14:1012-1018.
20. Casez JP, Lippuner K, Horber FF, Montandon A, Jaeger P: Changes in bone mineral density over 18 months following kidney transplantation: the respective roles of prednisone and parathyroid hormone. Nephrol Dial Transplant 2002;17:1318-1326.
21. Reinhardt W, Bartelworth H, Jockenhovel F, Schmidt-Gayk H, Witzke O, Wagner K, Heemann UW, Reinwein D, Philipp T, Mann K: Sequential changes of biochemical bone parameters after kidney transplantation. Nephrol Dial Transplant 1998;13:436-442.
22. Giannini S, D'Angelo A, Carraro G, Antonello A, Di LD, Marchini F, Plebani M, Zaninotto M, Rigotti P, Sartori L, Crepaldi G: Persistently increased bone turnover and low bone density in long-term survivors to kidney transplantation. Clin Nephrol 2001;56:353-363.
23. Kusec V, Smalcelj R, Cvijetic S, Rozman B, Skreb F: Determinants of reduced bone mineral density and increased bone turnover after kidney transplantation: cross-sectional study. Croat Med J 2000;41:396-400.
24. Rubello D, Giannini S, D'Angelo A, Nobile M, Carraio G, Rigotti P, Marchini F, Zaninotto M, Dalle CL, Sartori L, Nibale O, Carpi A: Secondary hyperparathyroidism is associated with vitamin D receptor polymorphism and bone density after renal transplantation. Biomed Pharmacother 2005;59:402-407.
25. Cayco AV, Wysolmerski J, Simpson C, Mitnick MA, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M: Posttransplant bone disease: evidence for a high bone resorption state. Transplantation 2000;70:1722-1728.
26. Torres A, Rodriguez AP, Concepcion MT, Garcia S, Rufino M, Martin B, Perez L, Machado M, de BE, Losada M, Hernandez D, Lorenzo V: Parathyroid function in longterm renal transplant patients: importance of pre-transplant PTH concentrations. Nephrol Dial Transplant 1998;13(suppl 3):94-97.
27. Horber FF, Casez JP, Steiger U, Czerniak A, Montandon A, Jaeger P: Changes in bone mass early after kidney transplantation. J Bone Miner Res 1994;9:1-9.
28. Almond MK, Kwan JT, Evans K, Cunningham J: Loss of regional bone mineral density in the first 12 months following renal transplantation. Nephron 1994;66:52-57.
29. Akcay A, Kanbay M, Huddam B, Usluogullari CA, Arat Z, Ozdemir FN, Haberal M: Relationship of posttransplantation erythrocytosis to hypercalcemia in renal transplant recipients. Transplant Proc 2005;37:3103-3105.
30. Al-Gabri S, Zadrazil J, Krejci K, Horak P, Bachleda P: Changes in bone mineral density and selected metabolic parameters over 24 months following renal transplantation. Transplant Proc 2005;37:1014-1019.
31. Brandenburg VM, Ketteler M, Fassbender WJ, Heussen N, Freuding T, Floege J, Ittel TH: Development of lumbar bone mineral density in the late course after kidney transplantation. Am J Kidney Dis 2002;40:1066-1074.
32. Ozdemir FN, Afsar B, Akgul A, Usluogullari C, Akcay A, Haberal M: Persistent hypercalcemia is a significant risk factor for graft dysfunction in renal transplantation recipients. Transplant Proc 2006;38:480-482.
33. Bagni B, Gilli P, Cavallini A, Bagni I, Marzola MC, Orzincolo C, Wahner HW: Continuing loss of vertebral mineral density in renal transplant recipients. Eur J Nucl Med 1994;21:108-112.
34. Brandenburg VM, Ketteler M, Heussen N, Politt D, Frank RD, Westenfeld R, Ittel TH, Floege J: Lumbar bone mineral density in very long-term renal transplant recipients: impact of circulating sex hormones. Osteoporos Int 2005;16:1611-1620.
35. Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ: Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study. Transplantation 2001;72:83-88.
36. Heaf J, Tvedegaard E, Kanstrup IL, Fogh-Andersen N: Bone loss after renal transplantation: role of hyperparathyroidism, acidosis, cyclosporine and systemic disease. Clin Transplant 2000;14:457-463.
37. Kusec V, Smalcelj R, Cvijetic S: Parathyroid hormone and bone mass after kidney transplantation. Acta Med Croatica 2002;56:17-20.
38. Malyszko J, Wolczynski S, Malyszko JS, Konstantynowicz J, Kaczmarski M, Mysliwiec M: Correlations of new markers of bone formation and resorption in kidney transplant recipients. Transplant Proc 2003;35:1351-1354.
39. Marcen R, Caballero C, Pascual J, Teruel JL, Tenorio M, Ocana J, Villafruela JJ, Burgos FJ, Fernandez AM, Muriel A, Ortuno J: Lumbar bone mineral density in renal transplant patients on neoral and tacrolimus: a four-year prospective study. Transplantation 2006;81:826-831.
40. Renau A, Yoldi B, Farrerons J, Sola R, Guirado L, Gich I: Bone mass and mineral metabolism in kidney transplant patients. Transplant Proc 2002;34:407.
41. Roe SD, Porter CJ, Godber IM, Hosking DJ, Cassidy MJ: Reduced bone mineral density in male renal transplant recipients: evidence for persisting hyperparathyroidism. Osteoporos Int 2005;16:142-148.
42. Torres A, Machado M, Concepcion MT, Martin N, Lorenzo V, Hernandez D, Rodriguez AP, Rodriguez A, de BE, Gonzalez-Posada JM, Hernandez A, Salido E: Influence of vitamin D receptor genotype on bone mass changes after renal transplantation. Kidney Int 1996;50:1726-1733.
43. Grotz WH, Mundinger FA, Gugel B, Exner VM, Kirste G, Schollmeyer PJ: Bone mineral density after kidney transplantation. A cross-sectional study in 190 graft recipients up to 20 years after transplantation. Transplantation 1995;59:982-986.
44. Moreno A, Torregrosa JV, Pons F, Campistol JM, Martinez De Osaba MJ, Oppenheimer F: Bone mineral density after renal transplantation: long-term follow-up. Transplant Proc 1999;31:2322-2323.
45. Ugur A, Guvener N, Isiklar I, Turan M, Erdal R, Haberal M: Osteoporosis after renal transplantation: single center experience. Transplantation 2001;71:645-649.
46. Palmer S, McGregor DO, Strippoli GF: Interventions for preventing bone disease in kidney transplant recipients. Cochrane Database Syst Rev 2005;2:CD005015.
47. Abdelhadi M, Nordenstrom J: Bone mineral recovery after parathyroidectomy in patients with primary and renal hyperparathyroidism. J Clin Endocrinol Metab 1998;83:3845-3851.
48. Evenepoel P, Claes K, Kuypers D, Maes B, Vanrenterghem Y: Impact of parathyroidectomy on renal graft function, blood pressure and serum lipids in kidney transplant recipients: a single centre study. Nephrol Dial Transplant 2005;20:1714-1720.
49. Garcia A, Mazuecos A, Garcia T, Gonzalez P, Ceballos M, Rivero M: Effect of parathyroidectomy on renal graft function. Transplant Proc 2005;37:1459-1461.
50. Kruse AE, Eisenberger U, Frey FJ, Mohaupt MG: The calcimimetic cinacalcet normalizes serum calcium in renal transplant patients with persistent hyperparathyroidism. Nephrol Dial Transplant 2005;20:1311-1314.
51. Leca N, Laftavi M, Gundroo A, Kohli R, Min I, Karam J, Sridhar N, Blessios G, Venuto R, Pankewycz O: Early and severe hyperparathyroidism associated with hypercalcemia after renal transplant treated with cinacalcet. Am J Transplant 2006;6:2391-2395.
52. Punch JD, Thompson NW, Merion RM: Subtotal parathyroidectomy in dialysis-dependent and post-renal transplant patients. A 25-year single-center experience. Arch Surg 1995;130:538-542.
53. Rostaing L, Moreau-Gaudry X, Baron E, Cisterne JM, Monrozies-Bernadet P, Durand D: Changes in blood pressure and renal function following subtotal parathyroidectomy in renal transplant patients presenting with persistent hypercalcemic hyperparathyroidism. Clin Nephrol 1997;47:248-255.
54. Schmid T, Muller P, Spelsberg F: Parathyroidectomy after renal transplantation: a retrospective analysis of long-term outcome. Nephrol Dial Transplant 1997;12:2393-2396.
55. Serra AL, Schwarz AA, Wick FH, Marti HP, Wuthrich RP: Successful treatment of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism. Nephrol Dial Transplant 2005;20:1315-1319.
56. Tanaci N, Karakose H, Guvener N, Tutuncu NB, Colak T, Haberal M: Influence of 1,25-dihydroxyvitamin D3 as an immunomodulator in renal transplant recipients: a retrospective cohort study. Transplant Proc 2003;35:2885-2887.
57. Toro J, Gentil MA, Garcia R, Perez-Valdivia MA, Garcia AE, Algarra GR, Pereira P, Gonzalez-Roncero F, Mateos J: Alendronate in kidney transplant patients: a single-center experience. Transplant Proc 2005;37:1471-1472.
58. Triponez F, Dosseh D, Hazzan M, Noel C, Vanhille P, Proye CA: Subtotal parathyroidectomy with thymectomy for autonomous hyperparathyroidism after renal transplantation. Br J Surg 2005;92:1282-1287.