Human blood neutrophil responses to prolonged exercise with and without a thermal clamp

Journal of Applied Physiology

Volumn 104, Issue 1, 2008, Pages 20-26

  Laing, Stewart J ^a   Jackson, Anna R ^a   Walters, Robert ^b   Lloyd Jones, Enid ^b   Whitham, Martin ^c   Maassen, Norbert ^d   Walsh, Neil P ^c,e  

^a NORTHWICK PARK HOSPITAL   (United Kingdom)

^b YSBYTY GWYNEDD   (United Kingdom)

^c BANGOR UNIVERSITY   (United Kingdom)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e BANGOR UNIVERSITY   (United Kingdom)

Author keywords

Environment; Heat; Immersion; Immune; Phagocyte

Indexed keywords

ADRENALIN; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROCORTISONE; INTERLEUKIN 6; NORADRENALIN; OXYGEN; STRESS HORMONE;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; BLOOD SAMPLING; CORE TEMPERATURE; EXERCISE; GROWTH HORMONE BLOOD LEVEL; HEATING; HUMAN; MALE; NEUTROPHIL; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WATER IMMERSION; WATER TEMPERATURE;

ADULT; BODY TEMPERATURE; CELL DEGRANULATION; CYTOKINES; EXERCISE; GRANULOCYTE COLONY-STIMULATING FACTOR; HORMONES; HUMANS; HYDROCORTISONE; HYPERTHERMIA, INDUCED; IMMERSION; INTERLEUKIN-6; LEUKOCYTE COUNT; MALE; NEUTROPHILS; NOREPINEPHRINE; TIME FACTORS; WATER;

EID: 38349059053     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00792.2007     Document Type: Article

References (44)

1. Athens JW, Raab SO, Haab OP, Mauer AM, Ashenbrucker H, Cartwright GE, Wintrobe MM. Leukokinetic studies. III. The distribution of granulocytes in the blood of normal subjects. J Clin Invest 40: 159-164, 1961.
2. Bierman HR, Kelly KH, Cordes FL, Petrakis NL, Kass H, Shpil EL. The influence of respiratory movements upon the circulating leukocytes. Blood 7: 533-544, 1952.
3. Bishop NC, Walsh NP, Scanlon GA. Effect of prolonged exercise and carbohydrate on total neutrophil elastase content. Med Sci Sports Exerc 35: 1326-1332, 2003.
4. Boldt J, Brosch C, Lehmann A, Suttner S, Isgro F. The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients. Anesth Analg 99: 1009-1017, 2004.
5. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14: 377-381, 1982.
6. Brenner IK, Zamecnik J, Shek PN, Shephard RJ. The impact of heat exposure and repeated exercise on circulating stress hormones. Eur J Appl Physiol 76: 445-454, 1997.
7. Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA. Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. Eur J Appl Physiol 75: 47-53, 1997.
8. Chudalla R, Baerwalde S, Schneider G, Maassen N. Local and systemic effects on blood lactate concentration during exercise with small and large muscle groups. Pflügers Arch 452: 690-697, 2006.
9. Cross MC, Radomski MW, VanHelder WP, Rhind SG, Shephard RJ. Endurance exercise with and without a thermal clamp: effects on leukocytes and leukocyte subsets. J Appl Physiol 81: 822-829, 1996.
10. De Haas M, Kerst JM, van der Schoot CE, Calafat J, Hack CE, Nuijens JH, Roos D, van Oers RH, dem Borne AE. Granulocyte colony-stimulating factor administration to healthy volunteers: analysis of the immediate activating effects on circulating neutrophils. Blood 84: 3885-3894, 1994.
11. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37: 247-248, 1974.
12. Ellis GS, Carlson DE, Hester L, He JR, Bagby GJ, Singh IS, Hasday JD. G-CSF, but not corticosterone, mediates circulating neutrophilia induced by febrile-range hyperthermia. J Appl Physiol 98: 1799-1804, 2005.
13. Fairbarn MS, Blackie SP, Pardy RL, Hogg JC. Comparison of effects of exercise and hyperventilation on leukocyte kinetics in humans. J Appl Physiol 75: 2425-2428, 1993.
14. Foster NK, Martyn JB, Rangno RE, Hogg JC, Pardy RL. Leukocytosis of exercise: role of cardiac output and catecholamines. J Appl Physiol 61: 2218-2223, 1986.
15. Henson PM, Zanolari B, Schwartzman NA, Hong SR. Intracellular control of human neutrophil secretion. I. C5a-induced stimulus-specific desensitization and the effects of cytochalasin. Br J Immunol 121: 851-855, 1978.
16. Hoffman-Goetz L, Pedersen BK. Exercise and the immune system: a model of the stress response? Immunol Today 15: 382-387, 1994.
17. Hollies NRS. Psychological scaling in comfort assessment. In: Clothing Comfort. Interaction of Thermal, Ventilation, Construction and Assessment Factors, edited by Hollies NRS, Goldman RF. Ann Arbor, MI: Science, 1977, p. 107-120.
18. Johnson JL, Moore EE, Tamura DY, Zallen G, Biffl WL, Silliman CC. Interleukin-6 augments neutrophil cytotoxic potential via selective enhancement of elastase release. J Surg Res 76: 91-94, 1998.
19. Kappel M, Hansen MB, Diamant M, Jorgensen JO, Gyhrs A, Pedersen BK. Effects of an acute bolus growth hormone infusion on the human immune system. Horm Metab Res 25: 579-585, 1993.
20. Kappel M, Stadeager C, Tvede N, Galbo H, Pedersen BK. Effects of in vivo hyperthermia on natural killer cell activity, in vitro proliferative responses and blood mononuclear cell subpopulations. Clin Exp Immunol 84: 175-180, 1991.
21. Kappel M, Tvede N, Galbo H, Haahr PM, Kjaer M, Linstow M, Klarlund K, Pedersen BK. Evidence that the effect of physical exercise on NK cell activity is mediated by epinephrine. J Appl Physiol 70: 2530-2534, 1991.
22. Laing SJ, Blackwell J, Gwynne D, Walters R, Walsh NP. Neutrophil degranulation response to 2 hours of exercise in a 30 degrees C environment. Aviat Space Environ Med 76: 1068-1073, 2005.
23. Li TL, Gleeson M. The effects of carbohydrate supplementation during the second of two prolonged cycling bouts on immunoendocrine responses. Eur J Appl Physiol 95: 391-399, 2005.
24. Nahas GG, Tannieres ML, Lennon JF. Direct measurement of leukocyte motility: effects of pH and temperature. Proc Soc Exp Biol Med 138: 350-352, 1971.
25. Niess AM, Fehrenbach E, Lehmann R, Opavsky L, Jesse M, Northoff H, Dickhuth HH. Impact of elevated ambient temperatures on the acute immune response to intensive endurance exercise. Eur J Appl Physiol 89: 344-351, 2003.
26. Orr Y, Taylor JM, Bannon PG, Geczy C, Kritharides L. Circulating CD10-/CD16low neutrophils provide a quantitative index of active bone marrow neutrophil release. Br J Haematol 131: 508-519, 2005.
27. Pedersen BK, Kappel M, Klokker M, Nielsen HB, Secher NH. The immune system during exposure to extreme physiologic conditions. Int J Sports Med 15, Suppl 3: S116-S121, 1994.
28. Reilly T, Dowzer CN, Cable NT. The physiology of deep-water running. J Sports Sci 21: 959-972, 2003.
29. Rhind SG, Gannon GA, Shek PN, Brenner IK, Severs Y, Zamecnik J, Buguet A, Natale VM, Shephard RJ, Radomski MW. Contribution of exertional hyperthermia to sympathoadrenal-mediated lymphocyte subset redistribution. J Appl Physiol 87: 1178-1185, 1999.
30. Roberts NJ Jr, Sandberg K. Hyperthermia and human leukocyte function. II. Enhanced production of and response to leukocyte migration inhibition factor (LIF). J Immunol 122: 1990-1993, 1979.
31. Roberts NJ Jr, Steigbigel RT. Hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils. Infect Immun 18: 673-679, 1977.
32. Roberts WO. Exercise-associated collapse in endurance events: a classification system. Physician Sportsmed 17: 49-55, 1989.
33. Robson PJ, Blannin AK, Walsh NP, Castell LM, Gleeson M. Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes. Int J Sports Med 20: 128-135, 1999.
34. Salak JL, McGlone JJ, Lyte M. Effects of in vitro adrenocorticotrophic hormone, cortisol and human recombinant interleukin-2 on porcine neutrophil migration and luminol-dependent chemiluminescence. Vet Immunol Immunopathol 39: 327-337, 1993.
35. Shirreffs SM, Maughan RJ. Urine osmolality and conductivity as indices of hydration status in athletes in the heat. Med Sci Sports Exerc 30: 1598-1602, 1998.
36. Starkie RL, Hargreaves M, Rolland J, Febbraio MA. Heat stress, cytokines, and the immune response to exercise. Brain Behav Immun 19: 404-412, 2005.
37. Suzuki K, Naganuma S, Totsuka M, Suzuki KJ, Mochizuki M, Shiraishi M, Nakaji S, Sugawara K. Effects of exhaustive endurance exercise and its one-week daily repetition on neutrophil count and functional status in untrained men. Int J Sports Med 17: 205-212, 1996.
38. Suzuki K, Nakaji S, Yamada M, Liu Q, Kurakake S, Okamura N, Kumae T, Umeda T, Sugawara K. Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Med Sci Sports Exerc 35: 348-355, 2003.
39. Tintinger GR, Theron AJ, Anderson R, Ker JA. The anti-inflammatory interactions of epinephrine with human neutrophils in vitro are achieved by cyclic AMP-mediated accelerated resequestration of cytosolic calcium. Biochem Pharmacol 61: 1319-1328, 2001.
40. Tonnesen E, Christensen NJ, Brinklov MM. Natural killer cell activity during cortisol and adrenaline infusion in healthy volunteers. Eur J Clin Invest 17: 497-503, 1987.
41. Walsh NP, Blannin AK, Bishop NC, Robson PJ, Gleeson M. Effect of oral glutamine supplementation on human neutrophil lipopolysaccharide-stimulated degranulation following prolonged exercise. Int J Sport Nutr Exerc Metab 10: 39-50, 2000.
42. Walsh NP, Whitham M. Exercising in environmental extremes: a greater threat to immune function? Sports Med 36: 941-976, 2006.
43. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349, 2000.
44. Yamada M, Suzuki K, Kudo S, Totsuka M, Nakaji S, Sugawara K. Raised plasma G-CSF and IL-6 after exercise may play a role in neutrophil mobilization into the circulation. J Appl Physiol 92: 1789-1794, 2002.