Cholesterol shows preference for the interior of polyunsaturated lipid membranes

Journal of the American Chemical Society

Volumn 130, Issue 1, 2008, Pages 10-11

  Marrink, Siewert J ^a   De Vries, Alex H ^a   Harroun, Thad A ^b   Katsaras, John ^b,c   Wassall, Stephen R ^d  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b BROCK UNIVERSITY   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^d INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; POLYUNSATURATED FATTY ACID;

ARTICLE; LIPID ANALYSIS; LIPID COMPOSITION; LIPID MEMBRANE; STRUCTURE ANALYSIS;

BINDING SITES; CHOLESTEROL; FATTY ACIDS, UNSATURATED; LIPID BILAYERS; NEUTRON DIFFRACTION; PHOSPHATIDYLCHOLINES;

EID: 38349032639     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja076641c     Document Type: Article

References (13)

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8. Simulations were performed using GROMACS: van der Spoel, D.; Lindahl, E.; Hess, B.; Groenhof, G.; Mark, A. E.; Berendsen, H. J. C. J. Comput. Chem. 2005, 26, 1701.
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10. The experimental profile also shows density for the cholesterol head group at the usual position around ±1.2 nm; see arrows in Figure 1A. Due to the limited resolution of the experimental data (∼1 nm), it is not clear whether this is realistic or an artifact from the reconstruction procedure.
11. An effective time scale is used; see Supporting Information.
12. Armstrong, V. T.; Brzustowicz, M. R.; Wassall, S. R.; Jenski, L. J.; Stillwell, W. Arch. Biochem. Biophys. 2003, 414, 74.
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