Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test

Experimental Physiology

Volumn 93, Issue 2, 2008, Pages 296-302

  Kawano, Hiroshi ^a,b   Tanimoto, Michiya ^a   Yamamoto, Kenta ^b   Sanada, Kiyoshi ^b   Gando, Yuko ^a,b   Tabata, Izumi ^a   Higuchi, Mitsuru ^b   Miyachi, Motohiko ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^b WASEDA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTERIAL STIFFNESS; ARTERY DIAMETER; ARTERY ENDOTHELIUM; ARTERY INTIMA; ARTICLE; B SCAN; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; CAROTID ARTERY; COLD PRESSOR TEST; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; HUMAN; MALE; MEAN ARTERIAL PRESSURE; MUSCLE STRENGTH; MUSCLE TRAINING; NORMAL HUMAN; SITTING; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE;

EID: 38349011286     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2007.039867     Document Type: Article

References (40)

1. American College of Sports Medicine Position Stand (1998). Exercise and physical activity for older adults. Med Sci Sports Exerc 30, 992 1008.
2. Bertovic DA, Waddell TK, Gatzka CD, Cameron JD, Dart AM & Kingwell BA (1999). Muscular strength training is associated with low arterial compliance and high pulse pressure. Hypertension 33, 1385 1391.
3. Cheung YF, Chan GC & Ha SY (2002). Arterial stiffness and endothelial function in patients with β-thalassemia major. Circulation 106, 2561 2566.
4. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J & Vogel R (2002). Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39, 257 265.
5. Corretti MC, Plotnick GD & Vogel RA (1995a). Correlation of cold pressor and flow-mediated brachial artery diameter responses with the presence of coronary artery disease. Am J Cardiol 75, 783 787.
6. Corretti MC, Plotnick GD & Vogel RA (1995b). The effects of age and gender on brachial artery endothelium-dependent vasoactivity are stimulus-dependent. Clin Cardiol 18, 471 476.
7. Cortez-Cooper MY, DeVan AE, Anton MM, Farrar RP, Beckwith KA, Todd JS & Tanaka H (2005). Effects of high intensity resistance training on arterial stiffness and wave reflection in women. Am J Hypertens 18, 930 934.
8. Gellman J, Hare J & Lowenstein C (1996). Intracoronary l-arginine normalizes the paradoxical response of atherosclerotic coronary arteries to adrenergic stimulation. Circulation 94, 242.
9. Haarbo J, Gotfredsen A, Hassager C & Christiansen C (1991). Validation of body composition by dual energy X-ray absorptiometry (DEXA). Clin Physiol 11, 331 341.
10. Hirai T, Sasayama S, Kawasaki T & Yagi S (1989). Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 80, 78 86.
11. Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A & Gutterman DD (2006). The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. J Am Coll Cardiol 48, 588 589.
12. Kawano H, Tanaka H & Miyachi M (2006). Resistance training and arterial compliance: keeping the benefits while minimizing the stiffening. J Hypertens 24, 1753 1759.
13. Kelly R, Hayward C, Avolio A & O'Rourke M (1989). Noninvasive determination of age-related changes in the human arterial pulse. Circulation 80, 1652 1659.
14. 2 vasoreactivity: association with endothelial dysfunction. Am J Physiol Heart Circ Physiol 291, H1856 H1861.
15. Lind L, Sarabi M, Millgard J, Kahan T & Edner M (1999). Endothelium-dependent vasodilation and structural and functional changes in the cardiovascular system are dependent on age in healthy subjects. Clin Physiol 19, 400 409.
16. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW & Ganz P (1986). Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 315, 1046 1051.
17. Miyachi M, Donato AJ, Yamamoto K, Takahashi K, Gates PE, Moreau KL & Tanaka H (2003). Greater age-related reductions in central arterial compliance in resistance-trained men. Hypertension 41, 130 135.
18. Miyachi M, Kawano H, Sugawara J, Takahashi K, Hayashi K, Yamazaki K, Tabata I & Tanaka H (2004). Unfavorable effects of resistance training on central arterial compliance: a randomized intervention study. Circulation 110, 2858 2863.
19. Miyachi M, Tanaka H, Kawano H, Okajima M & Tabata I (2005). Lack of age-related decreases in basal whole leg blood flow in resistance-trained men. J Appl Physiol 99, 1384 1390.
20. Miyachi M, Tanaka H, Yamamoto K, Yoshioka A, Takahashi K & Onodera S (2001). Effects of one-Legged endurance training on femoral arterial and venous size in healthy humans. J Appl Physiol 90, 2439 2444.
21. Moyna NM & Thompson PD (2004). The effect of physical activity on endothelial function in man. Acta Physiol Scand 180, 113 123.
22. Nabel EG, Ganz P, Gordon JB, Alexander RW & Selwyn AP (1988). Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. Circulation 77, 43 52.
23. Najjar SS, Scuteri A & Lakatta EG (2005). Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 46, 454 462.
24. Nakamura M, Sugawara S, Arakawa N, Nagano M, Shizuka T, Shimoda Y, Sakai T & Hiramori K (2004). Reduced vascular compliance is associated with impaired endothelium-dependent dilatation in the brachial artery of patients with congestive heart failure. J Card Fail 10, 36 42.
25. Nase GP & Boegehold MA (1996). Nitric oxide modulates arteriolar responses to increased sympathetic nerve activity. Am J Physiol Heart Circ Physiol 271, H860 H869.
26. Nichols W & O'Rourke M (1998). McDonald's Blood Flow in Arteries, Arnold, London, UK.
27. O'Rourke M (1990). Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension. Hypertension 15, 339 347.
28. Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, Limacher M, Pina IL, Stein RA, Williams M & Bazzarre T (2000). AHA Science Advisory. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription: An advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association; Position paper endorsed by the American College of Sports Medicine. Circulation 101, 828 833.
29. Pyke KE & Tschakovsky ME (2005). The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol 568, 357 369.
30. Rakobowchuk M, McGowan CL, de Groot PC, Hartman JW, Phillips SM & MacDonald MJ (2005). Endothelial function of young healthy males following whole body resistance training. J Appl Physiol 98, 2185 2190.
31. Rubenfire M, Rajagopalan S & Mosca L (2000). Carotid artery vasoreactivity in response to sympathetic stress correlates with coronary disease risk and is independent of wall thickness. J Am Coll Cardiol 36, 2192 2197.
32. Seals DR (1990). Sympathetic activation during the cold pressor test: influence of stimulus area. Clin Physiol 10, 123 129.
33. Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I & Salvetti A (1995). Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91, 1981 1987.
34. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA & Seals DR (2000). Aging, habitual exercise, and dynamic arterial compliance. Circulation 102, 1270 1275.
35. Tousoulis D, Davies G, Tentolouris C, Crake T & Toutouzas P (1997). Inhibition of nitric oxide synthesis during the cold pressor test in patients with coronary artery disease. Am J Cardiol 79, 1676 1679.
36. Van Merode T, Hick PJ, Hoeks AP, Rahn KH & Reneman RS (1988). Carotid artery wall properties in normotensive and borderline hypertensive subjects of various ages. Ultrasound Med Biol 14, 563 569.
37. Vita JA, Treasure CB, Yeung AC, Vekshtein VI, Fantasia GM, Fish RD, Ganz P & Selwyn AP (1992). Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Circulation 85, 1390 1397.
38. Yoshiga CC, Higuchi M & Oka J (2002). Rowing prevents muscle wasting in older men. Eur J Appl Physiol 88, 1 4.
39. Zanzinger J, Czachurski J & Seller H (1994). Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo. Circ Res 75, 1073 1077.
40. Zeiher AM, Drexler H, Wollschlaeger H, Saurbier B & Just H (1989). Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J Am Coll Cardiol 14, 1181 1190.