The human genioglossus response to negative airway pressure: Stimulus timing and route of delivery

Experimental Physiology

Volumn 93, Issue 2, 2008, Pages 288-295

  Doherty, Liam S ^a   Cullen, John P ^a   Nolan, Philip ^a,b   McNicholas, Walter T ^a,b  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AIRWAY DYNAMICS; AIRWAY PRESSURE; ARTICLE; BREATHING APPARATUS; BREATHING PATTERN; ELECTROMYOGRAM; EPIGLOTTIS; GENIOGLOSSUS MUSCLE; HUMAN; MALE; MUSCLE; MUSCLE EXCITATION; MUSCLE FUNCTION; NORMAL HUMAN; NOSE MUCOSA; SUPINE POSITION;

EID: 38349008632     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2007.039677     Document Type: Article

References (28)

1. Akahoshi T, White DP, Edwards JK, Beauregard J & Shea SA (2001). Phasic mechanoreceptor stimuli can induce phasic activation of upper airway muscles in humans. J Physiol 531, 677 691.
2. Doble EA, Leiter JC, Knuth SL, Daubenspeck JA & Bartlett D Jr. (1985). A noninvasive intraoral electromyographic electrode for genioglossus muscle. J Appl Physiol 58, 1378 1382.
3. Douglas NJ, Jan MA, Yildirim N, Warren PM & Drummond GB (1993). Effect of posture and breathing route on genioglossal electromyogram activity in normal subjects and in patients with the sleep apnea/hypopnea syndrome. Am Rev Respir Dis 148, 1341 1345.
4. Eastwood PR, Allison GT, Shepherd KL, Szollosi I & Hillman DR (2003). Heterogeneous activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodes. J Appl Physiol 94, 1849 1858.
5. Horner RL, Innes JA, Murphy K & Guz A (1991). Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressure in man. J Physiol 436, 15 29.
6. Lofaso F, d'Ortho MP, Fodil R, Delclaux C, Harf A & Lorino AM (2001). Abdominal muscle activity in sleep apnea during continuous positive airway pressure titration. Chest 120, 390 396.
7. Lorino AM, Lofaso F, Duizabo D, Zerah F, Goldenberg F, d'Ortho MP, Harf A & Lorino H (1998). Respiratory resistive impedance as an index of airway obstruction during nasal continuous positive airway pressure titration. Am J Respir Crit Care Med 158, 1465 1470.
8. Malhotra A, Fogel RB, Edwards JK, Shea SA & White DP (2000). Local mechanisms drive genioglossus activation in obstructive sleep apnea. Am J Respir Crit Care Med 161, 1746 1749.
9. Malhotra A, Pillar G, Fogel RB, Edwards JK, Ayas N, Akahoshi T, Hess D & White DP (2002). Pharyngeal pressure and flow effects on genioglossus activation in normal subjects. Am J Respir Crit Care Med 165, 71 77.
10. Mathew OP, Abu-Osba YK & Thach BT (1982). Influence of upper airway pressure changes on genioglossus muscle respiratory activity. J Appl Physiol 52, 438 444.
11. Mathur R, Mortimore IL, Jan MA & Douglas NJ (1995). Effect of breathing, pressure and posture on palatoglossal and genioglossal tone. Clin Sci (Lond) 89, 441 445.
12. Mortimore IL, Mathur R & Douglas NJ (1995). Effect of posture, route of respiration, and negative pressure on palatal muscle activity in humans. J Appl Physiol 79, 448 454.
13. Pillar G, Fogel RB, Malhotra A, Beauregard J, Edwards JK, Shea SA & White DP (2001). Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences. Respir Physiol 127, 23 38.
14. Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R & White DP (2000). Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender. Am J Respir Crit Care Med 162, 1627 1632.
15. Popovic RM & White DP (1995). Influence of gender on waking genioglossal electromyogram and upper airway resistance. Am J Respir Crit Care Med 152, 725 731.
16. Remmers JE, deGroot WJ, Sauerland EK & Anch AM (1978). Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 44, 931 938.
17. Saboisky JP, Butler JE, Fogel RB, Taylor JL, Trinder JA, White DP & Gandevia SC (2006). Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing. J Neurophysiol 95, 2213 2221.
18. Schneider H, Boudewyns A, Smith PL, O'Donnell CP, Canisius S, Stammnitz A, Allan L & Schwartz AR (2002). Modulation of upper airway collapsibility during sleep: influence of respiratory phase and flow regimen. J Appl Physiol 93, 1365 1376.
19. Schneider H, O'Hearn DJ, Leblanc K, Smith PL, O'Donnell CP, Eisele DW, Peter JH & Schwartz AR (2000). High-flow transtracheal insufflation treats obstructive sleep apnea. A pilot study. Am J Respir Crit Care Med 161, 1869 1876.
20. Shea SA, Akahoshi T, Edwards JK & White DP (2000). Influence of chemoreceptor stimuli on genioglossal response to negative pressure in humans. Am J Respir Crit Care Med 162, 559 565.
21. Stanchina ML, Malhotra A, Fogel RB, Trinder J, Edwards JK, Schory K & White DP (2003). The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep. Sleep 26, 851 856.
22. Strohl KP, Hensley MJ, Hallett M, Saunders NA & Ingram RH Jr. (1980). Activation of upper airway muscles before onset of inspiration in normal humans. J Appl Physiol 49, 638 642.
23. Tantucci C, Mehiri S, Duguet A, Similowski T, Arnulf I, Zelter M, Derenne JP & Milic-Emili J (1998). Application of negative expiratory pressure during expiration and activity of genioglossus in humans. J Appl Physiol 84, 1076 1082.
24. Tsuiki S, Ono T, Ishiwata Y & Kuroda T (2000). Functional divergence of human genioglossus motor units with respiratory-related activity. Eur Respir J 15, 906 910.
25. van Lunteren E, Van de Graaff WB, Parker DM, Mitra J, Haxhiu MA, Strohl KP & Cherniak NS (1984). Nasal and laryngeal reflex responses to negative upper airway pressure. J Appl Physiol 56, 746 752.
26. Wheatley JR, Mezzanotte WS, Tangel DJ & White DP (1993). Influence of sleep on genioglossus muscle activation by negative pressure in normal men. Am Rev Respir Dis 148, 597 605.
27. White DP, Edwards JK & Shea SA (1998). Local reflex mechanisms: influence on basal genioglossal muscle activation in normal subjects. Sleep 21, 719 728.
28. Woodall DL, Hokanson JA & Mathew OP (1989). Time of application of negative pressure pulses and upper airway muscle activity. J Appl Physiol 67, 366 370.