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2
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34447304106
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Walmsley SL, Thorne A, Loutfy MR, et al. A prospective randomized controlled trial of structured treatment interruption in HIV-infected patients failing highly active antiretroviral therapy (Canadian HIV Trials Network Study 164). J Acquir Immune Defic Syndr 2007; 45:418-425. A 12-week interruption did not increase the proportion of patients responding to salvage therapy.
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Walmsley SL, Thorne A, Loutfy MR, et al. A prospective randomized controlled trial of structured treatment interruption in HIV-infected patients failing highly active antiretroviral therapy (Canadian HIV Trials Network Study 164). J Acquir Immune Defic Syndr 2007; 45:418-425. A 12-week interruption did not increase the proportion of patients responding to salvage therapy.
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3
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33846024773
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Pai NP, Lawrence J, Reingold AL, Tulsky JP. Structured treatment interruptions (STI) in chronic unsuppressed HIV infection in adults. Cochrane Database Syst Rev 2006; 3:CD006148. This is a useful systematic review of studies in the setting of virological failure.
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Pai NP, Lawrence J, Reingold AL, Tulsky JP. Structured treatment interruptions (STI) in chronic unsuppressed HIV infection in adults. Cochrane Database Syst Rev 2006; 3:CD006148. This is a useful systematic review of studies in the setting of virological failure.
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4
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33748433647
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+ T-cell counts at 12 months.
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+ T-cell counts at 12 months.
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5
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33745086146
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Bloch MT, Smith DE, Quan D, et al. The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: final results from a randomized clinical trial (Pulse). J Acquir Immune Defic Syndr 2006; 42:192-202. Hydroxyurea was not of benefit when used with structured treatment interruptions in acute infection.
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Bloch MT, Smith DE, Quan D, et al. The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: final results from a randomized clinical trial (Pulse). J Acquir Immune Defic Syndr 2006; 42:192-202. Hydroxyurea was not of benefit when used with structured treatment interruptions in acute infection.
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6
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33747226141
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Structured treatment interruptions following immediate initiation of HAART in eight patients with acute HIV-1 seroconversion
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Vogel M, Lichterfeld M, Kaufmann DE, et al. Structured treatment interruptions following immediate initiation of HAART in eight patients with acute HIV-1 seroconversion. Eur J Med Res 2006; 11:273-278.
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(2006)
Eur J Med Res
, vol.11
, pp. 273-278
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Vogel, M.1
Lichterfeld, M.2
Kaufmann, D.E.3
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7
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33748078472
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Jacobson JM, Pat Bucy R, Spritzler J, et al. Evidence that intermittent structured treatment interruption, but not immunization with ALVAC-HIV vCP1452, promotes host control of HIV replication: the results of AIDS Clinical Trials Group 5068. J Infect Dis 2006; 194:623-632. This study provides proof of the auto-vaccination hypothesis, albeit in the setting of chronic infection.
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Jacobson JM, Pat Bucy R, Spritzler J, et al. Evidence that intermittent structured treatment interruption, but not immunization with ALVAC-HIV vCP1452, promotes host control of HIV replication: the results of AIDS Clinical Trials Group 5068. J Infect Dis 2006; 194:623-632. This study provides proof of the auto-vaccination hypothesis, albeit in the setting of chronic infection.
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8
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33751515147
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+ count-guided interruption of antiretroviral treatment
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This massive study is one of the most important and influential trials ever conducted in HIV medicine. It has changed clinical practice and continues to provide a wealth of data that will shape our understanding of the pathogenesis of HIV disease and the benefits of antiretroviral therapy
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+ count-guided interruption of antiretroviral treatment. N Engl J Med 2006; 355:2283-2296. This massive study is one of the most important and influential trials ever conducted in HIV medicine. It has changed clinical practice and continues to provide a wealth of data that will shape our understanding of the pathogenesis of HIV disease and the benefits of antiretroviral therapy.
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(2006)
N Engl J Med
, vol.355
, pp. 2283-2296
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El-Sadr, W.M.1
Lundgren, J.D.2
Neaton, J.D.3
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9
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34248149928
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Interruption of antiretroviral treatment in HIV-infected patients with preserved immune function is associated with a low rate of clinical progression: A prospective study by AIDS Clinical Trials Group 5170
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Skiest DJ, Su Z, Havlir DV, et al. Interruption of antiretroviral treatment in HIV-infected patients with preserved immune function is associated with a low rate of clinical progression: a prospective study by AIDS Clinical Trials Group 5170. J Infect Dis 2007; 195:1426-1436.
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(2007)
J Infect Dis
, vol.195
, pp. 1426-1436
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Skiest, D.J.1
Su, Z.2
Havlir, D.V.3
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10
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33745003258
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CD4-guided structured antiretroviral treatment interruption strategy in HIV-infected adults in west Africa (Trivacan ANRS 1269 trial): A randomised trial
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This SMART-like study performed in Africa showed even more dramatic negative clinical consequences of treatment interruption
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Danel C, Moh R, Minga A, et al. CD4-guided structured antiretroviral treatment interruption strategy in HIV-infected adults in west Africa (Trivacan ANRS 1269 trial): a randomised trial. Lancet 2006; 367:1981-1989. This SMART-like study performed in Africa showed even more dramatic negative clinical consequences of treatment interruption.
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(2006)
Lancet
, vol.367
, pp. 1981-1989
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Danel, C.1
Moh, R.2
Minga, A.3
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11
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34748902968
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Estimates of opportunistic infection incidence or death within specific CD4 strata in HIV-infected patients in Abidjan. Cote d'Ivoire: Impact of alternative methods of CD4 count modelling
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Deuffic-Burban S, Losina E, Wang B, et al. Estimates of opportunistic infection incidence or death within specific CD4 strata in HIV-infected patients in Abidjan. Cote d'Ivoire: impact of alternative methods of CD4 count modelling. Eur J Epidemiol 2007; 22:737-744.
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(2007)
Eur J Epidemiol
, vol.22
, pp. 737-744
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Deuffic-Burban, S.1
Losina, E.2
Wang, B.3
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12
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33746479812
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CD4-guided scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1: Results of the Staccato randomised trial
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+ threshold than used in SMART or Trivacan may minimize clinical risks
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+ threshold than used in SMART or Trivacan may minimize clinical risks.
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(2006)
Lancet
, vol.368
, pp. 459-465
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Ananworanich, J.1
Gayet-Ageron, A.2
Le Braz, M.3
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13
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38149101507
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Hakim J, on behalf of the DART Team. A structured treatment interruption (STI) strategy of 12 week cycles on and off ART is clinically inferior to continuous treatment in patients with low CD4 counts before ART: a randomisation within the DART trial [abstract]. In: Proceedings of the XVI International AIDS Conference; 13-18 August 2006; Toronto, Canada. International AIDS Society: Geneva, Switzerland; 2006. http://www.aids2006.org/PAG/ Abstracts.aspx?AID=51163 [accessed 14 November].
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Hakim J, on behalf of the DART Team. A structured treatment interruption (STI) strategy of 12 week cycles on and off ART is clinically inferior to continuous treatment in patients with low CD4 counts before ART: a randomisation within the DART trial [abstract]. In: Proceedings of the XVI International AIDS Conference; 13-18 August 2006; Toronto, Canada. International AIDS Society: Geneva, Switzerland; 2006. http://www.aids2006.org/PAG/ Abstracts.aspx?AID=51163 [accessed 14 November].
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14
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33847036340
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Intermittent antiretroviral therapy in patients with controlled HIV infection
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+ decline, although minor HIV-related events were more common
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+ decline, although minor HIV-related events were more common.
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(2007)
AIDS
, vol.21
, pp. 457-466
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Marchou, B.1
Tangre, P.2
Charreau, I.3
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15
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34848865063
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Determinants of virologic and immunologic outcomes in chronically HIV-infected subjects undergoing repeated treatment interruptions: The Istituto Superiore di Sanita-Pulsed Antiretroviral Therapy (ISS-PART) Study
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+ decline and emergence of resistance mutations
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+ decline and emergence of resistance mutations.
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(2007)
J Acquir Immune Defic Syndr
, vol.46
, pp. 39-47
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Palmisano, L.1
Giuliano, M.2
Bucciardini, R.3
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16
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34047198735
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Cohen CJ, Colson AE, Sheble-Hall AG, et al. Pilot study of a novel short-cycle antiretroviral treatment interruption strategy: 48-week results of the five-dayson, two-days-off (FOTO) study. HIV Clin Trials 2007; 8:19-23. This is an interesting pilot study of an interruption strategy for people desiring drug-free weekends, which deserves evaluation in a large-scale randomized trial.
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Cohen CJ, Colson AE, Sheble-Hall AG, et al. Pilot study of a novel short-cycle antiretroviral treatment interruption strategy: 48-week results of the five-dayson, two-days-off (FOTO) study. HIV Clin Trials 2007; 8:19-23. This is an interesting pilot study of an interruption strategy for people desiring drug-free weekends, which deserves evaluation in a large-scale randomized trial.
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17
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34047154061
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Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection
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Outlines a more systematic approach to designing future interruption interventions
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Rosenberg ES, Davidian M, Banks HT. Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection. Drug Alcohol Depend 2007; 88 (Suppl 2):S41-S51. Outlines a more systematic approach to designing future interruption interventions.
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(2007)
Drug Alcohol Depend
, vol.88
, Issue.SUPPL. 2
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Rosenberg, E.S.1
Davidian, M.2
Banks, H.T.3
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18
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33646205051
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Role of parametric resonance in virological failure during HIV treatment interruption therapy
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Breban R, Blower S. Role of parametric resonance in virological failure during HIV treatment interruption therapy. Lancet 2006; 367:1285-1289.
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(2006)
Lancet
, vol.367
, pp. 1285-1289
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Breban, R.1
Blower, S.2
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19
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38149137091
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Cohn D, for the SMART Study Group. Severity and types of clinical events by proximal CD4 cell counts in the SMART study [abstract THPE0047]. In: Proceedings of the XVI International AIDS Conference; 13-18 August 2006; Toronto, Canada. International AIDS Society: Geneva, Switzerland; 2006. http://www.iasociety.org/Default.aspx?pageId=11&abstractId=2194513 [accessed 14 November 2007].
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Cohn D, for the SMART Study Group. Severity and types of clinical events by proximal CD4 cell counts in the SMART study [abstract THPE0047]. In: Proceedings of the XVI International AIDS Conference; 13-18 August 2006; Toronto, Canada. International AIDS Society: Geneva, Switzerland; 2006. http://www.iasociety.org/Default.aspx?pageId=11&abstractId=2194513 [accessed 14 November 2007].
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20
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34548222243
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Risk of cancers during interrupted antiretroviral therapy in the SMART study
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This study shows that non-AIDS-defining malignancies dominate in the HAART era
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Silverberg MJ, Neuhaus J, Bower M, et al. Risk of cancers during interrupted antiretroviral therapy in the SMART study. AIDS 2007; 21:1957-1963. This study shows that non-AIDS-defining malignancies dominate in the HAART era.
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(2007)
AIDS
, vol.21
, pp. 1957-1963
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Silverberg, M.J.1
Neuhaus, J.2
Bower, M.3
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21
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38149039182
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Prineas R, Roediger M, Carr A, et al. Effect of alternate treatment protocols on the incidence of electrocardiographic abnormalities among HIV infected adults in the SMART trial [abstract WEPEB077]. In: Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia. International AIDS Society: Geneva, Switzerland; 2007. http://www.iasociety.org/Default.aspx?pageId=11& abstractId=200703664 [accessed 14 November 2007]
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Prineas R, Roediger M, Carr A, et al. Effect of alternate treatment protocols on the incidence of electrocardiographic abnormalities among HIV infected adults in the SMART trial [abstract WEPEB077]. In: Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia. International AIDS Society: Geneva, Switzerland; 2007. http://www.iasociety.org/Default.aspx?pageId=11& abstractId=200703664 [accessed 14 November 2007]
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22
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Gordin F, Roediger M, Clezy K, et al. An increased risk of bacterial pneumonia in patients interrupting antiretroviral treatment: results from the SMART study [abstract MOPEB100]. In: Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia. International AIDS Society: Geneva, Switzerland; 2007. http://www.iasociety. org/Default.aspx?pageId=11&abstractId=200701627 [accessed 14 November 2007].
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Gordin F, Roediger M, Clezy K, et al. An increased risk of bacterial pneumonia in patients interrupting antiretroviral treatment: results from the SMART study [abstract MOPEB100]. In: Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia. International AIDS Society: Geneva, Switzerland; 2007. http://www.iasociety. org/Default.aspx?pageId=11&abstractId=200701627 [accessed 14 November 2007].
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23
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Tedaldi E, Puoti M, Neuhaus J, et al. Opportunistic disease and mortality in patients co-infected with hepatitis C virus (HCV) and/or hepatitis B virus (HBV) in the SMART (Strategic Management of Antiretroviral Therapy) study [abstract TUAB203]. In: Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia. International AIDS Society: Geneva, Switzerland; 2007. http://www.iasociety.org/ Default. aspx?pageId=11&abstractId=200703450 [accessed 14 November 2007].
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Tedaldi E, Puoti M, Neuhaus J, et al. Opportunistic disease and mortality in patients co-infected with hepatitis C virus (HCV) and/or hepatitis B virus (HBV) in the SMART (Strategic Management of Antiretroviral Therapy) study [abstract TUAB203]. In: Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia. International AIDS Society: Geneva, Switzerland; 2007. http://www.iasociety.org/ Default. aspx?pageId=11&abstractId=200703450 [accessed 14 November 2007].
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Higher rate of antitretroviral therapy reinitiation among HIV-HBV coinfected patients in the episodic therapy arm of the SMART study
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abstract TUAB204, 22-25 July, Sydney, Australia. International AIDS Society: Geneva, Switzerland;, accessed 14 November 2007
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Dore G, Soriano V, Neuhaus J, et al. Higher rate of antitretroviral therapy reinitiation among HIV-HBV coinfected patients in the episodic therapy arm of the SMART study [abstract TUAB204]. In: Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia. International AIDS Society: Geneva, Switzerland; 2007. http://www.iasociety.org/Default.aspx?pageId=11&abstractId= 200704389 [accessed 14 November 2007].
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(2007)
Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
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Dore, G.1
Soriano, V.2
Neuhaus, J.3
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25
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38149119478
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The effect of episodic ART on HIV transmission risk: A substudy of the SMART study
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abstract 979, accessed 14 November 2007
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Burman W, Grund B, Neuhaus J, et al. The effect of episodic ART on HIV transmission risk: a substudy of the SMART study [abstract 979]. In: Proceedings of the 14th Conference on Retroviruses and Opportunistic Infections; 25-28 February 2007; Los Angeles, California. Alaexandria, Virginia: Conference on Retroviruses and Opportunistic Infections; 2007. http://www. retroconference.org/2007/Abstracts/28742.htm [accessed 14 November 2007].
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(2007)
Proceedings of the 14th Conference on Retroviruses and Opportunistic Infections; 25-28 February 2007; Los Angeles, California. Alaexandria, Virginia: Conference on Retroviruses and Opportunistic Infections
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Burman, W.1
Grund, B.2
Neuhaus, J.3
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26
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33745949890
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Dynamics of T cells subsets and lymphoproliferative responses during structured treatment interruption cycles and after definitive interruption of HAART in early chronic HIV type-1-infected patients
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Libois A, Lopez A, Garcia F, et al. Dynamics of T cells subsets and lymphoproliferative responses during structured treatment interruption cycles and after definitive interruption of HAART in early chronic HIV type-1-infected patients. AIDS Res Hum Retroviruses 2006; 22:657-666.
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(2006)
AIDS Res Hum Retroviruses
, vol.22
, pp. 657-666
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Libois, A.1
Lopez, A.2
Garcia, F.3
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27
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Ferritin levels during structured treatment interruption of highly active antiretroviral therapy
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Boom J, Kosters E, Duncombe C, et al. Ferritin levels during structured treatment interruption of highly active antiretroviral therapy. HIV Med 2007; 8:388-395.
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(2007)
HIV Med
, vol.8
, pp. 388-395
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Boom, J.1
Kosters, E.2
Duncombe, C.3
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28
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Structured intermittent interruption of chronic HIV infection treatment with highly active antiretroviral therapy: Effects on leptin and TNF-alpha
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Arjona MM, Perez-Cano R, Garcia-Juarez R, et al. Structured intermittent interruption of chronic HIV infection treatment with highly active antiretroviral therapy: effects on leptin and TNF-alpha. AIDS Res Hum Retroviruses 2006; 22:307-314.
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(2006)
AIDS Res Hum Retroviruses
, vol.22
, pp. 307-314
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Arjona, M.M.1
Perez-Cano, R.2
Garcia-Juarez, R.3
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29
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34547798122
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Stopping antiretroviral therapy
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This is a useful review of stopping strategies to avoid NNRTI resistance
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Taylor S, Boffito M, Khoo S, et al. Stopping antiretroviral therapy. AIDS 2007; 21:1673-1682. This is a useful review of stopping strategies to avoid NNRTI resistance.
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(2007)
AIDS
, vol.21
, pp. 1673-1682
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Taylor, S.1
Boffito, M.2
Khoo, S.3
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30
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34147106431
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Nevirapine clearance from plasma in African adults stopping therapy: A pharmacokinetic substudy
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This study shows prolonged clearance of nevirapine in African patients interrupting therapy, suggesting the need for a longer period of NRTI cover
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Kikaire B, Khoo S, Walker AS, et al. Nevirapine clearance from plasma in African adults stopping therapy: a pharmacokinetic substudy. AIDS 2007; 21:733-737. This study shows prolonged clearance of nevirapine in African patients interrupting therapy, suggesting the need for a longer period of NRTI cover.
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(2007)
AIDS
, vol.21
, pp. 733-737
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Kikaire, B.1
Khoo, S.2
Walker, A.S.3
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31
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31044456584
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Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: An Adult AIDS Clinical Trials Group Study
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This important study demonstrates the effect of genetic variability on efavirenz clearance
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Ribaudo HJ, Haas DW, Tierney C, et al. Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study. Clin Infect Dis 2006; 42:401-407. This important study demonstrates the effect of genetic variability on efavirenz clearance.
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(2006)
Clin Infect Dis
, vol.42
, pp. 401-407
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Ribaudo, H.J.1
Haas, D.W.2
Tierney, C.3
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32
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Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society: USA panel
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Hammer SM, Saag MS, Schechter M, et al. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society: USA panel. JAMA 2006; 296:827-843.
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(2006)
JAMA
, vol.296
, pp. 827-843
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Hammer, S.M.1
Saag, M.S.2
Schechter, M.3
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