A regulatory role of interleukin 15 in wound healing and mucosal infection in mice

Journal of Leukocyte Biology

Volumn 83, Issue 1, 2008, Pages 165-172

  Kagimoto, Yoshiko ^a   Yamada, Hisakata ^a   Ishikawa, Takahiro ^a   Maeda, Naoyoshi ^a   Goshima, Fumi ^b   Nishiyama, Yukihiro ^b   Furue, Masutaka ^a   Yoshikai, Yasunobu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

T cells; Cytokines; Immune regulation; Immunity

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; FEMALE; GENITAL TRACT INFECTION; HERPES SIMPLEX VIRUS 2; LYMPHOCYTE FUNCTION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SKIN EPITHELIUM; SKIN INFECTION; T LYMPHOCYTE; TRANSGENIC MOUSE; WOUND HEALING;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS I; INTERFERON TYPE II; INTERLEUKIN-15; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUCOUS MEMBRANE; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

HUMAN HERPESVIRUS 2; MUS; MUS MUSCULUS;

EID: 38149124788     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0307137     Document Type: Article

References (51)

1. Haas, W., Pereira, P., Tonegawa, S. (1993) γ/δ Cells. Annu. Rev. Immunol. 11, 637-685.
2. Hayday, A., Tigelaar, R. (2003) Immunoregulation in the tissues by T cells. Nat. Rev. Immunol. 3, 233-242.
3. Kabelitz, D., Marischen, L., Oberg, H. H., Holtmeier, W., Wesch, D. (2005) Epithelial defense by γ δ T cells. Int. Arch. Allergy Immunol. 137, 73-81.
4. Komori, H. K., Meehan, T. F., Havran, W. L. (2006) Epithelial and mucosal γ δ T cells. Curr. Opin. Immunol. 18, 534-538.
5. Born, W., Cady, C., Jones-Carson, J., Mukasa, A., Lahn, M., O'Brien, R. (1999) Immunoregulatory functions of γ δ T cells. Adv. Immunol. 71, 77-144.
6. Jameson, J., Ugarte, K., Chen, N., Yachi, P., Fuchs, E., Boismenu, R., Havran, W. L. (2002) A role for skin T cells in wound repair. Science 296, 747-749.
7. Sharp, L. L., Jameson, J. M., Cauvi, G., Havran, W. L. (2005) Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1. Nat. Immunol. 6, 73-79.
8. Girardi, M., Lewis, J., Glusac, E., Filler, R. B., Geng, L., Hayday, A. C., Tigelaar, R. E. (2002) Resident skin-specific T cells provide local, non-redundant regulation of cutaneous inflammation. J. Exp. Med. 195, 855-867.
9. Jameson, J. M., Cauvi, G., Sharp, L. L., Witherden, D. A., Havran, W. L. (2005) γδ T cell-induced hyaluronan production by epithelial cells regulates inflammation. J. Exp. Med. 201, 1269-1279.
10. Stanberry, L. R. (1992) Pathogenesis of herpes simplex virus infection and animal models for its study. Curr. Top. Microbiol. Immunol. 179, 15-30.
11. Whitley, R. J. (1996) Herpes simplex viruses. In Virology, 3rd ed. (B. N. Fields, D. Knipe, P. M. Howley, eds.), Philadelphia, PA, USA, Lippincott-Raven, 2297-2342.
12. Parr, M. B., Parr, E. L. (1998) Mucosal immunity to herpes simplex virus type 2 infection in the mouse vagina is impaired by in vivo depletion of T lymphocytes. J. Virol. 72, 2677-2685.
13. Schmid, D. S., Rouse, B. T. (1992) The role of T cell immunity in control of herpes simplex virus. Curr. Top. Microbiol. Immunol. 179, 57-74.
14. Manickan, E., Rouse, R. J., Yu, Z., Wire, W. S., Rouse, B. T. (1995) Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes. J. Immunol. 155, 259-265.
15. Nishimura, H., Yajima, T., Kagimoto, Y., Ohata, M., Watase, T., Kishihara, K., Goshima, F., Nishiyama, Y., Yoshikai, Y. (2004) Intraepithelial γ/δ T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2. J. Virol. 78, 4927-4930.
16. Bamford, R. N., Grant, A. J., Burton, J. D., Peters, C., Kurys, G., Goldman, C. K., Brennan, J., Roessler, E., Waldmann, T. A. (1994) The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91, 4940-4944.
17. Giri, J. G., Ahdieh, M., Eisenman, J., Shanebeck, K., Grabstein, K., Kumaki, S., Namen, A., Park, L. S., Cosman, D., Anderson, D. (1994) Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13, 2822-2830.
18. Grabstein, K. H., Eisenman, J., Shanebeck, K., Rauch, C., Srinivasan, S., Fung, V., Beers, C., Richardson, J., Schoenborn, M. A., Ahdieh, M., Richardson, L., Alderson, M. R., Watson, J. D., Anderson, D. M., Giri, J. G. (1994) Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264, 965-968.
19. Tagaya, Y., Bamford, R. N., DeFilippis, A. P., Waldmann, T. A. (1996) IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4, 329-336.
20. Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S., Ma, A. (1998) IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9, 669-676.
21. Kennedy, M. K., Glaccum, M., Brown, S. N., Butz, E. A., Viney, J. L., Embers, M., Matsuki, N., Charrier, K., Sedger, L., Willis, C. R., Brasel, K., Morrissey, P. J., Stocking, K., Schuh, J. C., Joyce, S., Peschon, J. J. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191, 771-780.
22. De Creus, A., Van Beneden, K., Stevenaert, F., Debacker, V., Plum, J., Leclercq, G. (2002) Developmental and functional defects of thymic and epidermal V γ 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice. J. Immunol. 168, 6486-6493.
23. Ashkar, A. A., Rosenthal, K. L. (2003) Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J. Virol. 77, 10168-10171.
24. Gill, N., Rosenthal, K. L., Ashkar, A. A. (2005) NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection. J. Virol. 79, 4470-4478.
25. Nishimura, H., Yajima, T., Naiki, Y., Tsunobuchi, H., Umemura, M., Itano, K., Matsuguchi, T., Suzuki, M., Ohashi, P. S., Yoshikai, Y. (2000) Differential roles of interleukin-15 mRNA isoforms generated by alternative splicing in immune responses in vivo. J. Exp. Med. 191, 157-170.
26. Umemura, M., Nishimura, H., Hirose, K., Matsuguchi, T., Yoshikai, Y. (2001) Over-expression of IL-15 in vivo induces a predominant Tcl response in mice inoculated with Mycobacterium bovis Bacille Calmette-Guerin infection. J. Immunol. 167, 946-956.
27. +T cells increased in IL-15 transgenic mice are involved in early protection a primary infection with Listeria monocytogenes. Eur. J. Immunol. 31, 757-766.
28. Umemura, M., Nishimura, H., Yajima, T., Wajjwalku, W., Matsuguchi, T., Takahashi, M., Nishiyama, Y., Makino, M., Nagai, Y., Yoshikai, Y. (2002) Over-expression of interleukin 15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome. FASEB J. 16, 1755-1763.
29. Nishiyama, Y., Rapp, F. (1981) Repair replication of viral and cellular DNA in herpes simplex virus type 2-infected human embryonic and xeroderma pigmentosum cells. Virology 110, 466-475.
30. Havran, W. L., Chien, Y. H., Allison, J. P. (1991) Recognition of self antigens by skin-derived T cells with invariant γ δ antigen receptors. Science 252, 1430-1432.
31. Rakasz, E., Hagen, M., Sandor, M., Lynch, R. G. (1997) γ δ T cells of the murine vagina: T cell response in vivo in the absence of the expression of CD2 and CD28 molecules. Int. Immunol. 9, 161-167.
32. Wang, X. J., Han, G., Owens, P., Siddiqui, Y., Li, A. G. (2006) Role of TGF β-mediated inflammation in cutaneous wound healing. J. Invest. Dermatol. Symp. Proc. 11, 112-117.
33. Workalemahu, G., Foerster, M., Kroegel, C. (2004) Expression and synthesis of fibroblast growth factor-9 in human γδ T-lymphocytes. Response to isopentenyl pyrophosphate and TGF-β1/IL-15. J. Leukoc. Biol. 75, 657-663.
34. Workalemahu, G., Foerster, M., Kroegel, C., Braun, R. K. (2003) Human γ δ-T lymphocytes express and synthesize connective tissue growth factor: effect of IL-15 and TGF-β1 and comparison with β-T lymphocytes. J. Immunol. 170, 153-157.
35. Monteleone, G., Pallone, F., MacDonald, T. T. (2004) Smad7 in TGF-β-mediated negative regulation of gut inflammation. Trends Immunol. 25, 513-517.
36. Young, H. A. (2006) Unraveling the pros and cons of interferon-γ gene regulation. Immunity 24, 506-507.
37. Suzuki, T., Hiromatsu, K., Ando, Y., Okamoto, T., Tomoda, Y., Yoshikai, Y. (1995) Regulatory role of γ δ T cells in uterine intraepithelial lymphocytes in maternal antifetal immune responses. J. Immunol. 154, 4476-4484.
38. Mukasa, A., Born, W. K., O'Brien, R. L. (1999) Inflammation alone evokes the response of a TCR-invariant mouse γ δ T cell subset. J. Immunol. 162, 4910-4913.
39. Nakazato, K., Yamada, H., Yajima, T., Kagimoto, Y., Kuwano, H., Yoshikai, Y. (2007) Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCR γ δ intestinal intraepithelial T lymphocytes in IL-15-deficient mice. J. Immunol. 178, 757-764.
40. Nishimura, H., Fujimoto, A., Naoyuki, T., Yajima, T., Wajjwalku, W., Yoshikai, Y. (2005) A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing. FASEB J. 19, 19-28.
41. Macdonald, T. T., Monteleone, G. (2005) Immunity, inflammation, and allergy in the gut. Science 307, 1920-1925.
42. Weiner, H. L. (2001) Induction and mechanism of action of transforming growth factor-β secreting Th3 regulatory cells. Immunol. Rev. 182, 207-214.
43. Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. A., Weiner, H. L. (1994) Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237-1240.
44. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742.
45. + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421, 388-392.
46. Izcue, A., Coombes, J. L., Powrie, F. (2006) Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212, 256-271.
47. Wing, K., Fehervari, Z., Sakaguchi, S. (2006) Emerging possibilities in the development and function of regulatory T cells. Int. Immunol. 18, 991-1000.
48. Clark, R. A., Kupper, T. S. (2007) IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 109, 194-202.
49. Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., Murphy, K. M. (2006) Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24, 677-688.
50. Obermeier, F., Hausmann, M., Kellermeier, S., Kiessling, S., Strauch, U. G., Duitman, E., Bulfone-Paus, S., Herfarth, H., Bock, J., Dunger, N., Stoeck, M., Scholmerich, J., Falk, W., Rogler, G. (2006) IL-15 protects intestinal epithelial cells. Eur. J. Immunol. 36, 2691-2699.
51. O'Kane, S., Ferguson, M. W. (1997) Transforming growth factor β s and wound healing. Int. J. Biochem. Cell Biol. 29, 63-78.