Protective effect of Withania somnifera dunal root extract against protracted social isolation induced behavior in rats

Indian Journal of Physiology and Pharmacology

Volumn 51, Issue 4, 2007, Pages 345-353

  Gupta, Girdhari Lal ^a   Rana, Avtar Chand ^a  

^a BN College of Pharmacy ^*  (India)

Author keywords

Anxiety; Depression; Diazepam; Social isolation stress; Withania somnifera

Indexed keywords

DIAZEPAM; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; FORCED SWIMMING TEST; IMMOBILIZATION; MALE; MAZE TEST; NONHUMAN; PLANT ROOT; RAT; RESPONSE TIME; SOCIAL ISOLATION; TRANQUILIZING ACTIVITY; WITHANIA SOMNIFERA;

ANIMALS; DIAZEPAM; MALE; MAZE LEARNING; PLANT EXTRACTS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SOCIAL ISOLATION; STRESS, PSYCHOLOGICAL; SWIMMING; WITHANIA;

EID: 38149115405     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ehlers CL, Wall TL, Wyss SP, Chaplin RI. Social zeitgebers: a peer separation model of depression in rats. In: Koob G, Ehlers CL, Kupfer DJ, editors. Animal models of depression. Boston' Birkhauser 1989; 99-110.
2. Parker V, Morinan A. The socially-isolated rats as a model for anxiety. Neuropharmacology 1986; 25: 663-664.
3. Dong E, Matsumoto K, Tohda M, Kaneko Y, Watanabe H. Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice. Neurosci Res 1999; 33: 171-177.
4. Dong E, Matsumoto K, Watanabe H. Involvement of peripheral type of benzodiazepine receptor in social isolation stress-induced decrease in pentobarbital sleep in mice. Life Sci 1999; 65: 1561-1568.
5. Dong E, Matsumoto K, Uzunova V, Sugaya I, Takahata H, Nomura H, Watanabe H, Costa E, Guidotti A. Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc Natl Acad Sci 2001; 98: 2849-2854.
6. Karim A, Arslan MI. Isolation modifies the behavioural response in rats. Bangladesh Med Res Counc Bull 2000; 26: 27-32.
7. Guidotti A, Dong E, Matsumoto K, Pinna G, Rasmusson AM, Costa E. The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Res 2001; 37: 110-115.
8. Ago Y, Matsuda T. Brain microdialysis of isolation-reared mice under freely-moving conditions. Nippon Yakurigaku Zasshi 2003; 122: 135-140.
9. Hirani K, Sharma AN, Jain NS, Ugale RR, Chopde CT. Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology 2005; 180: 267-278.
10. Woods JH, Katz JL, Winger G. Benzodiazepines: use, abuse and consequences. Pharmacol Rev 1992; 44: 151-347.
11. Gupta GL, Rana AC. Withania somnifera (Ashwagandha): A Review. Phcog Rev 2007; 1: 129-136.
12. A receptor complex. Indian J Med Res 1991; 94: 312-315.
13. Kaur P, Sharma M, Mathur S, Tiwari M, Divekar HM, Kumar R, Srivastava KK, Chandra R. Effect of 1-oxo-5beta, 6beta-epoxy-witha-2-ene-27-ethoxy-olide isolated from the roots of Withania somnifera on stress indices in Wistar rats. J Altern Complement Med 2003; 9: 897-907.
14. Jain S, Shukla SD, Sharma K, Bhatnagar M. Neuroprotective effects of Withania somnifera Dunn in hippocampal sub-regions of female albino rat. Phytother Res 2001; 15: 544-548.
15. Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav 2003; 75: 547-555.
16. Kumar A, Kulkarni SK. Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism. Phytother Res 2006; 20: 538-541.
17. A receptor function in rat brain. J Neurochem 2000; 75: 732-740.
18. Stahl E. In: Thin Layer Chromatography, A Laboratory Handbook, 2nd edition. Allen and Unwin: London 1964; 311-357.
19. Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 1986; 24: 525-529.
20. Porsolt RD, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977; 266: 730-732.
21. Bertoglio LJ, Carobrez AP. Prior maze experience required to alter midazolam effects in rats submitted to the elevated plus-maze. Pharmacol Biochem Behav 2002; 72: 449-455.
22. Garzon J, Del Rio J. Hyperactivity induced in rats by long-term isolation: further studies on a new animal model for the detection of antidepressants. Eur J Pharmacol 1981; 74: 287-294.
23. Miura H, Qiao H, Ohta T. Attenuating effects of the isolated rearing condition on increased brain serotonin and dopamine turnover elicited by novelty stress. Brain Res 2002; 926: 10-17.
24. Lapiz MD, Mateo Y, Parker T, Marsden C. Effects of noradrenaline depletion in the brain on response on novelty in isolation-reared rats. Psychopharmacology 2000; 152: 312-320.
25. Strome EM, Wheler GH, Higley JD, Loriaux DL, Suomi SJ, Doudet DJ. Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates. Proc Natl Acad Sci 2002; 99: 15749-15754.
26. Vasar E, Peuranen E, Harro J, Lang A, Oreland L, Mannisto PT. Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein. Naunyn Schmiedebergs Arch Pharmacol 1993; 348: 96-101.
27. Rupniak NM, Carlson EC, Harrison T, Oates B, Seward E, Owen S, de Felipe C, Hunt S, Wheeldon A. Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice. Neuropharmacology 2000; 39: 1413-1421.
28. Alexander SL, Irvine CH, Livesey JH, Donald RA. Effect of isolation stress on concentrations of arginine vasopressin, alpha-melanocyte-stimulating hormone and ACTH in the pituitary venous effluent of the normal horse. J Endocrinol 1988; 116: 325-334.
29. Miura H, Qiao H, Ohta T. Attenuating effects of the isolated rearing condition on increased brain serotonin and dopamine turnover elicited by novelty stress. Brain Res 2002; 926: 10-17.
30. Waselus M, Valentino RJ, Van Bockstaele EJ. Ultrastructural evidence for a role of gamma-aminobutyric acid in mediating the effects of corticotropin-releasing factor on the rat dorsal raphe serotonin system. J Comp Neurol 2005; 482: 155-165.
31. Dawson GR, Crawford SP, Collinson N, Iversen SD, Tricklebank MD. Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity. Psychopharmacology 1995; 118: 316-323.
32. Kokare DM, Chopde CT, Subhedar NK. Participation of alpha-melanocyte stimulating hormone in ethanol-induced anxiolysis and withdrawal anxiety in rats. Neuropharmacology 2006; 51: 536-545.