Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides

European Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2008, Pages 1105-1113

  Dolezal, Martin ^a   Cmedlova, Pavlina ^a   Palek, Lukas ^a   Vinsova, Jarmila ^a   Kunes, Jiri ^a   Buchta, Vladimir ^b   Jampilek, Josef ^c   Kralova, Katarina ^d  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c Zentiva Prague   (Czech Republic)

^d Physics and Informatics   (Slovakia)

Author keywords

Antialgal activity; Antifungal; Antimycobacterial; In vitro; Lipophilicity determination; Photosynthesis inhibiting; Pyrazinecarboxamides; Structure activity relationships

Indexed keywords

5 TERT BUTYL 6 CHLORO N (3 TRIFLUOROMETHYLPHENYL)PYRAZINE 2 CARBOXAMIDE; N (3 TRIFLUOROMETHYLPHENYL)PYRAZINE 2 CARBOXAMIDE; N PHENYLPYRAZINE 2 CARBOXAMIDE DERIVATIVE; PYRAZINAMIDE; PYRAZINE 2 CARBOXYLIC ACID (3 TRIFLUOROMETHYLPHENYL)AMIDE; PYRAZINE 2 CARBOXYLIC ACID AMIDE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHOTOSYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CERCOPITHECUS AETHIOPS; CHLORELLA VULGARIS; CHLOROPHYLL; CHLOROPLASTS; HERBICIDES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PYRAZINES; SPINACIA OLERACEA; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 38149088496     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.07.013     Document Type: Article

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