Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans

Journal of Biological Chemistry

Volumn 283, Issue 2, 2008, Pages 1179-1188

  Song, Wen Liang ^a   Wang, Miao ^a   Ricciotti, Emanuela ^a   Fries, Susanne ^a   Yu, Ying ^a   Grosser, Tilo ^a   Reilly, Muredach ^a   Lawson, John A ^a   FitzGerald, Garret A ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Department of Translational Medicine and Therapeutics ^*

^c School of Veterinary Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN URINE; INFLAMMATORY DISEASE; LEUKOCYTE FUNCTIONS; MOUSE URINE; URINARY METABOLITE;

BIOSYNTHESIS; DISEASES; ENZYME ACTIVITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

LIVING SYSTEMS STUDIES;

11 EPIPROSTAGLANDIN F2 ALPHA; 11,15 DIOXO 9ALPHA HYDROXY 2,3,4,5 TETRANORPROSTAN 1,20 DIOIC ACID; ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; LIPOPOLYSACCHARIDE; NICOTINIC ACID; PROSTAGLANDIN D2; PROSTAGLANDIN SYNTHASE; PROSTANOIC ACID; ROFECOXIB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INHIBITION; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLITE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN ANALYSIS; SINGLE DRUG DOSE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE INHIBITORS; DIMERIZATION; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LACTONES; LIPOCALINS; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROSTAGLANDIN D2; PROSTANOIC ACIDS; SULFONES;

BACTERIA (MICROORGANISMS); MUS;

EID: 38149061171     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706839200     Document Type: Article

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