Reversal of P-glycoprotein-mediated drug efflux by eudesmin from Haplophyllum perforatum and cytotoxicity pattern versus diphyllin, podophyllotoxin and etoposide

Planta Medica

Volumn 73, Issue 15, 2007, Pages 1563-1567

  Lim, Suzanne ^a,b   Grassi, Jérôme ^c   Akhmedjanova, Valentina ^d   Debiton, Eric ^a,b   Balansard, Guy ^e   Beliveau, Richard ^c   Barthomeuf, Chantal ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c UNIVERSITY OF MONTREAL   (Canada)

^d S Yu Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences   (Uzbekistan)

^e AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Cytotoxicity; Diphyllin; Eudesmin; Haplophyllum perforatum; Lignans; P glycoprotein; Rutaceae

Indexed keywords

DIPROPHYLLINE; ETOPOSIDE; EUDESMIN; GLYCOPROTEIN P; HAPLOPHYLLUM PERFORATUM EXTRACT; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PLANT EXTRACT; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG; VINBLASTINE;

ARTICLE; BREAST CANCER; CELL STRAIN; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; HAPLOPHYLLUM PERFORATUM; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; MULTIDRUG RESISTANCE; NONHUMAN; SOLID TUMOR;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DIOXOLANES; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; FURANS; HUMANS; LIGNANS; P-GLYCOPROTEIN; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; PODOPHYLLOTOXIN; RUTACEAE;

HAPLOPHYLLUM; RUTACEAE;

EID: 38149045034     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-993754     Document Type: Article

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