Prometheus: From legend to the real liver support therapy

International Journal of Artificial Organs

Volumn 30, Issue 10, 2007, Pages 858-863

  Rifai, K ^a   Tetta, C ^b   Ronco, Claudio ^c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FRESENIUS MEDICAL CARE   (Germany)

^c SAN BORTOLO HOSPITAL   (Italy)

Author keywords

Adsorption; Extracorporeal treatments; Liver failure

Indexed keywords

ARTIFICIAL ORGANS; BIOCOMPATIBILITY; DIALYSIS; PORE SIZE; TECHNOLOGY TRANSFER;

ARTIFICIAL LIVER SUPPORT SYSTEMS; BLOOD PURIFICATION; CHEMICAL NATURE; EXTRACORPOREAL TREATMENT; INTRINSIC CHARACTERISTICS; LIVER DISEASE; LIVER FAILURE; PARTICLES-SIZE DISTRIBUTIONS; PORE-SIZE DISTRIBUTION; PROMETHEUS;

ADSORPTION;

ADSORPTION KINETICS; ALBUMIN DIALYSIS; BIOCOMPATIBILITY; FLOW; HEMODIALYSIS; HEMOFILTRATION; HUMAN; LIVER FAILURE; LIVER SUPPORT; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPTIC SHOCK; TREATMENT INDICATION;

EID: 38149027586     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880703001002     Document Type: Review

References (20)

1. Yatzidis H. A convenient hemoperfusion microapparatus over charcoal for the treatment of endogenous and exogenous intoxification: its use as an effective artificial kidney. Proc Eur Dial Transplant Assoc 1964; 1: 83-7.
2. La Greca G, Brendolan A, Ghezzi PM, et al. The concept of sorbent in hemodialysis. Int J Artif Organs 1998; 21: 303-8.
3. De Nitti C Giordano R, Gervasio R, et al. Choosing new adsorbents for endogenous ultrapure infusion fluid: performances, safety and flow distribution. Int J Artif Organs 2001; 24: 765-76.
4. Winchester JF, Silberzweig J, Ronco C, et al. Sorbents in acute renal failure and end-stage renal disease: middle molecule and cytokine removal. Blood Purif 2004; 22: 73-7.
5. Tetta C, Bellomo R, Brendolan A, Piccinni P, Digito A, Dan M, Irone M, Lonnemann G, Moscato D, Buades J, La Greca G, Ronco C. Use of adsorptive mechanisms in continuous renal replacement therapies in the critically ill. Kidney Int Suppl 1999; 72: S15-9.
6. Kellum J, Song M, Venkataran M, Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemia. Crit Care Med 2004; 32: 801-5.
7. Stange J, Hassanein TI, Mehta R, et al. The molecular adsorbent recycling system (as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective rabdomized, controlled clinical trial, and clinical experience from 19 centres). Int J Artif Organs 2002; 26: 103-10.
8. Strobl W, Vogt G, Mitteregger R, et al. [The "fractionated plasma separation and adsorption system" (FPSA), a new membrane adsorption-assisted adjunctive extracorporeal blood purification system for liver failure]. Biomed Tech (Berl) 1998; 43 (Suppl): S168-9.
9. Falkenhagen D, Strobl W, Vogt G, et al. Fractionated plasma separation and adsorption system: a novel system for blood purification to remove albumin bound substances. Artif Organs 1999; 23: 81-6.
10. Krause A. Prometheus - a new extracorporeal liver support therapy. In: Arroyo V, Forns X, Garcia-Pagán JC, Rodés J, Eds. Progress in the Treatment of Liver Diseases. Barcelona, Spain: Ars Medica 2003, pp 437-43.
11. Krisper P, Stauber RE. Tecnology insight: artificial extra-corporeal liver support - how does Prometheus compare with MARS? Nat Clin Pract Nephrol 2007; 3: 267-76.
12. Evenpoel P, Laleman W, Wilmer A, et al. Prometheus versus Molecular Adsorbents Recirculating system: comparison of efficiency in two different liver detoxification devices. Artif Organs 2006; 30: 276-84.
13. Jalan R, Williams R. Acute-on-chronic liverfailure: pathophysiological basis of therapeutic options. Blood Purif 2002; 20: 252-61.
14. Evenepoel P, Laleman W, Wilmer A, et al. Detoxifying capacity and kinetics of Prometheus - a new extracorporeal system for the treatment of liver failure. Blood Purif 2005; 23: 349-58.
15. Skwarek A, Grodzicki M, Nyckowski P, et al. The use Prometheus FPSA system in the treatment of acute liver failure: preliminary results. Transplant Proc 2006; 38: 209-11.
16. Rifai K, Ernst T, Kretschmer U, et al. The Prometheus® device for extracorporeal support of combined liver and renal failure. Blood Purif 2005; 23: 298-302.
17. Santoro A, Mancini E, Fieramosca E, Faenza S. Liver support systems. Contrib Nephrol 2007; 156: 396-404.
18. Liu J, Kjaergard LL, Als-Nilsen B, et al. Artificial and bioartificial support systems for liver failure: a Cochrane Hepato-Biliary Group Protocol. Liver 2002; 22: 433-8.
19. Rifai K, Hafer C, Rosenau J, et al. Treatment of severe refractory pruritus with fractionated plasma separation and adsorption (Prometheus®). Scand J Gastroenterol 2006; 41: 1212-7.
20. Meijers BK, Verhamme P, Nevens F, et al. Major coagulation disturbances during Fractionated Plasma Separation and Adsorption. Am J Transplant 2007; 7: 2195-9.