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Volumn 8, Issue 3, 2007, Pages 239-251

Molecular targets in squamous cell carcinoma of the head and neck

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; BORTEZOMIB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; GEFITINIB; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE; HYDROXYUREA; IMATINIB; IRINOTECAN; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MATUZUMAB; PACLITAXEL; PANITUMUMAB; PLATINUM COMPLEX; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT PROTEIN; SORAFENIB; SUNITINIB; TRASTUZUMAB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VB4 845; ZALUTUMUMAB;

EID: 38149020563     PISSN: 15272729     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11864-007-0030-4     Document Type: Article
Times cited : (22)

References (60)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 2000, 100(1):57-70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 23944515326 scopus 로고    scopus 로고
    • Intracellular signal transduction pathway proteins as targets for cancer therapy
    • Adjei AA, Hidalgo M: Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Oncol 2005, 23(23):5386-5403
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5386-5403
    • Adjei, A.A.1    Hidalgo, M.2
  • 3
    • 33749018813 scopus 로고    scopus 로고
    • Clinical implications of the mechanism of epidermal growth factor receptor inhibitors
    • Marshall J: Clinical implications of the mechanism of epidermal growth factor receptor inhibitors. Cancer 2006, 107(6):1207-1218
    • (2006) Cancer , vol.107 , Issue.6 , pp. 1207-1218
    • Marshall, J.1
  • 4
    • 23844498514 scopus 로고    scopus 로고
    • The role of cetuximab in the treatment of squamous cell cancer of the head and neck
    • Burtness B: The role of cetuximab in the treatment of squamous cell cancer of the head and neck. Expert Opin Biol Ther 2005, 5(8):1085-1093
    • (2005) Expert Opin Biol Ther , vol.5 , Issue.8 , pp. 1085-1093
    • Burtness, B.1
  • 5
    • 0020933452 scopus 로고
    • Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
    • Sato JD, Kawamoto T, Le AD, Mendelsohn J, Polikoff J, Sato GH: Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med 1983, 1(5):511-529
    • (1983) Mol Biol Med , vol.1 , Issue.5 , pp. 511-529
    • Sato, J.D.1    Kawamoto, T.2    Le, A.D.3    Mendelsohn, J.4    Polikoff, J.5    Sato, G.H.6
  • 7
    • 33644971314 scopus 로고    scopus 로고
    • Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: A pilot phase II study of a new combined-modality paradigm
    • Pfister DG, Su YB, Kraus DH, Wolden SL, Lis E, Aliff TB, Zahalsky AJ, Lake S, Needle MN, Shaha AR et al: Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: A pilot phase II study of a new combined-modality paradigm. J Clin Oncol 2006, 24(7):1072-1078
    • (2006) J Clin Oncol , vol.24 , Issue.7 , pp. 1072-1078
    • Pfister, D.G.1    Su, Y.B.2    Kraus, D.H.3    Wolden, S.L.4    Lis, E.5    Aliff, T.B.6    Zahalsky, A.J.7    Lake, S.8    Needle, M.N.9    Shaha, A.R.10
  • 8
    • 41949107494 scopus 로고    scopus 로고
    • Experience with cetuximab plus paclitaxel/carboplatinum in primary platinum-resistant recurrent head and neck cancer
    • [abstract 6077] June 20 Supplement 6077
    • Buentzel J, Vries Ad, Micke O: Experience with cetuximab plus paclitaxel/ carboplatinum in primary platinum-resistant recurrent head and neck cancer [abstract 6077] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6077
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Buentzel, J.1    Vries, A.D.2    Micke, O.3
  • 10
    • 38149123171 scopus 로고    scopus 로고
    • Phase II evaluation of cetuximab (C225) combined with induction paclitaxel and carboplatin followed by C225, paclitaxel, carboplatin, and radiation for stage III/IV operable squamous cancer of the head and neck (ECOG, E2303)
    • [abstract 6015] June 20 Supplement: 6015
    • Wanebo HJ, Ghebremichael M, Burtness B, Spencer S, Ridge J, Forastiere A, Ghebremichael M: Phase II evaluation of cetuximab (C225) combined with induction paclitaxel and carboplatin followed by C225, paclitaxel, carboplatin, and radiation for stage III/IV operable squamous cancer of the head and neck (ECOG, E2303) [abstract 6015] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6015
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Wanebo, H.J.1    Ghebremichael, M.2    Burtness, B.3    Spencer, S.4    Ridge, J.5    Forastiere, A.6    Ghebremichael, M.7
  • 11
    • 47349120856 scopus 로고    scopus 로고
    • Phase II trial of docetaxel (T), cisplatin (P), and cetuximab (E) followed by concurrent radiation (RT), P, and E in locally advanced head and neck squamous cell carcinoma (HNSCC)
    • [abstract 6051] June 20 Supplement 6051
    • Argiris A, Karamouzis MV, Heron DE, Smith R, Ferris R, Lai S, Kim S, Branstetter B, Johnson J, Grandis J: Phase II trial of docetaxel (T), cisplatin (P), and cetuximab (E) followed by concurrent radiation (RT), P, and E in locally advanced head and neck squamous cell carcinoma (HNSCC) [abstract 6051] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6051
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Argiris, A.1    Karamouzis, M.V.2    Heron, D.E.3    Smith, R.4    Ferris, R.5    Lai, S.6    Kim, S.7    Branstetter, B.8    Johnson, J.9    Grandis, J.10
  • 12
    • 47349101706 scopus 로고    scopus 로고
    • Cetuximab (C-mab) and chemo-radiation (CT-RT) for loco-regional advanced squamous cell carcinoma of the head and neck (HNC): A phase II study
    • [abstract 6043] June 20 Supplement 6043
    • Merlano C, Russi EG, Benasso M, Colantonio I, Vigna Taglianti R, Lanzilotta L, Vigo V, Bacigalupo A: Cetuximab (C-mab) and chemo-radiation (CT-RT) for loco-regional advanced squamous cell carcinoma of the head and neck (HNC): A phase II study [abstract 6043] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6043
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Merlano, C.1    Russi, E.G.2    Benasso, M.3    Colantonio, I.4    Vigna Taglianti, R.5    Lanzilotta, L.6    Vigo, V.7    Bacigalupo, A.8
  • 13
    • 36048934209 scopus 로고    scopus 로고
    • Cetuximab extends survival of patients with recurrent or metastatic SCCHN when added to first line platinum based therapy - Results of a randomized phase III (Extreme) study
    • Vermorken J, Mesia R, Vega V, Remenar E, Hitt R, Kawecki A, Rottey S, Amellal N, Cupissol D, Licitra L: Cetuximab extends survival of patients with recurrent or metastatic SCCHN when added to first line platinum based therapy - Results of a randomized phase III (Extreme) study. ASCO Ann Meet 2007
    • (2007) ASCO Ann Meet
    • Vermorken, J.1    Mesia, R.2    Vega, V.3    Remenar, E.4    Hitt, R.5    Kawecki, A.6    Rottey, S.7    Amellal, N.8    Cupissol, D.9    Licitra, L.10
  • 14
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
    • Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA: Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study. J Clin Oncol 2005, 23(34):8646-8654
    • (2005) J Clin Oncol , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 15
    • 41949121745 scopus 로고    scopus 로고
    • Phase II study of combination cetuximab and weekly paclitaxel in patients with metastatic/recurrent squamous cell carcinoma of head and neck (SCCHN): Spanish Head and Neck Cancer Group (TTCC)
    • [abstract 6012] June 20 Supplement 6012
    • Hitt R, Irigoyen A, Nuñez J, Grau J, Saenz JG, Pastor M, Jara C, Giron CG, Hidalgo M, Hernandez JC: Phase II study of combination cetuximab and weekly paclitaxel in patients with metastatic/recurrent squamous cell carcinoma of head and neck (SCCHN): Spanish Head and Neck Cancer Group (TTCC) [abstract 6012] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6012
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Hitt, R.1    Irigoyen, A.2    Nuñez, J.3    Grau, J.4    Saenz, J.G.5    Pastor, M.6    Jara, C.7    Giron, C.G.8    Hidalgo, M.9    Hernandez, J.C.10
  • 16
    • 38149099099 scopus 로고    scopus 로고
    • A Phase I Study of Adjuvant OSI-774 (Tarcevaé) in Patients Following Combined Chemo-Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (NCT00079053). National Cancer Institute of Canada
    • A Phase I Study of Adjuvant OSI-774 (Tarcevaé) in Patients Following Combined Chemo-Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (NCT00079053). National Cancer Institute of Canada
  • 17
    • 38149044780 scopus 로고    scopus 로고
    • A Randomised, Double-Blind, Placebo-Controlled, Multi-Centre, Phase III Study of Post-Operative Adjuvant Lapatinib or Placebo and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib or Placebo Monotherapy in High-Risk Subjects With Resected Squamous Cell Carcinoma of the Head and Neck (NCT00424255). International
    • A Randomised, Double-Blind, Placebo-Controlled, Multi-Centre, Phase III Study of Post-Operative Adjuvant Lapatinib or Placebo and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib or Placebo Monotherapy in High-Risk Subjects With Resected Squamous Cell Carcinoma of the Head and Neck (NCT00424255). International
  • 18
    • 0037115674 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    • Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, Fu KK, Milas L: Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 2002, 62(24):7350-7356
    • (2002) Cancer Res , vol.62 , Issue.24 , pp. 7350-7356
    • Ang, K.K.1    Berkey, B.A.2    Tu, X.3    Zhang, H.Z.4    Katz, R.5    Hammond, E.H.6    Fu, K.K.7    Milas, L.8
  • 19
    • 38149099838 scopus 로고    scopus 로고
    • EGFR expression by immunohistochemistry (IHC) and response to chemotheraphy and cetuximab in squamous cell carcinoma of the head and neck (SCCHN)
    • [abstract 6024]. June 20 Supplement 6024
    • Kies M, Ghebremichael M, Katz T: EGFR expression by immunohistochemistry (IHC) and response to chemotheraphy and cetuximab in squamous cell carcinoma of the head and neck (SCCHN) [abstract 6024]. J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6024
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Kies, M.1    Ghebremichael, M.2    Katz, T.3
  • 20
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies, Abstract 817
    • Saltz L, Kies M, Abbruzzese JL, Azarnia N, Needle M: The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Abstract 817. Proc Am Soc Clin Oncol 2003, 22
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.L.3    Azarnia, N.4    Needle, M.5
  • 21
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining?
    • Perez-Soler R, Saltz L: Cutaneous adverse effects with HER1/ EGFR-targeted agents: Is there a silver lining? J Clin Oncol 2005, 23(22):5235-5246
    • (2005) J Clin Oncol , vol.23 , Issue.22 , pp. 5235-5246
    • Perez-Soler, R.1    Saltz, L.2
  • 22
    • 34547174846 scopus 로고    scopus 로고
    • Cetuximab dose-escalation study in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic and efficacy data of a randomized study. Abstract 237
    • Cutsem EV, Humblet Y, Gelderblom H, Vermorken JB, Viret F, Glimelius B, Ciardiello F, Gallerani E, Amellal N, Peeters M: Cetuximab dose-escalation study in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic and efficacy data of a randomized study. Abstract 237. Gastrointestinal Cancers Symposium, 2007
    • (2007) Gastrointestinal Cancers Symposium
    • Cutsem, E.V.1    Humblet, Y.2    Gelderblom, H.3    Vermorken, J.B.4    Viret, F.5    Glimelius, B.6    Ciardiello, F.7    Gallerani, E.8    Amellal, N.9    Peeters, M.10
  • 23
    • 33749014247 scopus 로고    scopus 로고
    • Anti-EGFR mechanism of action: Antitumor effect and underlying cause of adverse events
    • Lenz HJ: Anti-EGFR mechanAsm of action: antitumor effect and underlying cause of adverse events. Oncology (Williston Park) 2006, 20(5 Suppl 2):5-13
    • (2006) Oncology (Williston Park) , vol.20 , Issue.5 SUPPL. 2 , pp. 5-13
    • Lenz, H.J.1
  • 24
    • 3442891161 scopus 로고    scopus 로고
    • Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
    • Huang S, Armstrong EA, Benavente S, Chinnaiyan P, Harari PM: Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res 2004, 64(15):5355-5362
    • (2004) Cancer Res , vol.64 , Issue.15 , pp. 5355-5362
    • Huang, S.1    Armstrong, E.A.2    Benavente, S.3    Chinnaiyan, P.4    Harari, P.M.5
  • 25
    • 17444378212 scopus 로고    scopus 로고
    • Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Impact on cell growth and molecular factors
    • Fischel JL, Formento P, Milano G: Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Impact on cell growth and molecular factors. Br J Cancer 2005, 92(6):1063-1068
    • (2005) Br J Cancer , vol.92 , Issue.6 , pp. 1063-1068
    • Fischel, J.L.1    Formento, P.2    Milano, G.3
  • 26
    • 38149079591 scopus 로고    scopus 로고
    • Randomized Study of Bevacizumab/Tarceva and Tarceva/Sulindac in Squamous Cell Carcinoma of the Head and Neck (NCT00392665). Dana-Farber Cancer Institute
    • Randomized Study of Bevacizumab/Tarceva and Tarceva/Sulindac in Squamous Cell Carcinoma of the Head and Neck (NCT00392665). Dana-Farber Cancer Institute
  • 27
    • 38149137920 scopus 로고    scopus 로고
    • Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer (NCT00140556). Duke University
    • Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer (NCT00140556). Duke University
  • 28
    • 38149125376 scopus 로고    scopus 로고
    • A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer (NCT00409565). University of Pittsburgh
    • A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer (NCT00409565). University of Pittsburgh
  • 29
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Rosen F, Stadler WM, Recant W, Stenson K, Huo D, Vokes EE: Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003, 21(10):1980-1987
    • (2003) J Clin Oncol , vol.21 , Issue.10 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3    Recant, W.4    Stenson, K.5    Huo, D.6    Vokes, E.E.7
  • 31
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL: Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004, 22(1):77-85
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarwala, S.S.5    Siu, L.L.6
  • 32
    • 29144496710 scopus 로고    scopus 로고
    • Integration of Gefitinib (G), into a Concurrent Chemoradiation (CRT) Regimen Followed by G Adjuvant Therapy in Patients with Locally Advanced Head and Neck Cancer (HNC)'a Phase II Trial
    • [abstract 5506] June 20 Supplement 5506
    • Cohen EE, Haraf DJ, Stenson KM, Blair E, Brockstein BE, Mauer AM, Dekker A, Williams R, Lester E, Vokes EE: Integration of Gefitinib (G), into a Concurrent Chemoradiation (CRT) Regimen Followed by G Adjuvant Therapy in Patients with Locally Advanced Head and Neck Cancer (HNC)'a Phase II Trial [abstract 5506] J Clin Oncol, ASCO Ann Meet Proc 2005, 23(16S, Part I of II, June 20 Supplement):5506
    • (2005) J Clin Oncol, ASCO Ann Meet Proc , vol.23 , Issue.PART of II
    • Cohen, E.E.1    Haraf, D.J.2    Stenson, K.M.3    Blair, E.4    Brockstein, B.E.5    Mauer, A.M.6    Dekker, A.7    Williams, R.8    Lester, E.9    Vokes, E.E.10
  • 35
    • 38149091412 scopus 로고    scopus 로고
    • Sequence-dependent cytoxicity of docetaxel and erlotinib in head and neck squamous cell carcinoma (HNSCC)
    • [abstract 6084] June 20 Supplement 6084
    • Glisson BS, Saigal B, Xu Y, Johnson FM: Sequence-dependent cytoxicity of docetaxel and erlotinib in head and neck squamous cell carcinoma (HNSCC) [abstract 6084] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6084
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Glisson, B.S.1    Saigal, B.2    Xu, Y.3    Johnson, F.M.4
  • 36
    • 38149026887 scopus 로고    scopus 로고
    • Open-Labeled An Trial With a Dose-Escalation Part and a Parallel Group Design Investigating Zalutumumab, an Anti-EGF Receptor Antibody, in Combination With Chemo-Radiation as First Line Treatment of Patients With Cancer of the Head and Neck (NCT00401401). Internation
    • An Open-Labeled Trial With a Dose-Escalation Part and a Parallel Group Design Investigating Zalutumumab, an Anti-EGF Receptor Antibody, in Combination With Chemo-Radiation as First Line Treatment of Patients With Cancer of the Head and Neck (NCT00401401). Internation
  • 37
    • 38149108118 scopus 로고    scopus 로고
    • An Open-Labeled Randomized Parallel Group Trial of Zalutumumab, a Human Monoclonal Anti-EGFr Antibody, in Combination With Best Supportive Care (BSC) vs BSC, in Pts With Non-Curable SCCHN Who Have Failed Standard Platinum-Based Chemotherapy (NCT00382031). International
    • An Open-Labeled Randomized Parallel Group Trial of Zalutumumab, a Human Monoclonal Anti-EGFr Antibody, in Combination With Best Supportive Care (BSC) vs BSC, in Pts With Non-Curable SCCHN Who Have Failed Standard Platinum-Based Chemotherapy (NCT00382031). International
  • 38
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara N: Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 2004, 9(Suppl 1):2-10
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 2-10
    • Ferrara, N.1
  • 41
    • 44649195401 scopus 로고    scopus 로고
    • Randomized phase II study of concomitant chemoradiotherapy with 5-fluorouracil-hydroxyurea (FHX) compared to FHX and bevazicumab (BFHX) in intermediate stage head and neck cancer (HNC)
    • [abstract 6034] June 20 Supplement 6034
    • Choong NW, Haraf DJ, Cohen EE, Stenson KM, Blair EA, Dekker A, Williams R, Karrison TG, Vokes EE: Randomized phase II study of concomitant chemoradiotherapy with 5-fluorouracil-hydroxyurea (FHX) compared to FHX and bevazicumab (BFHX) in intermediate stage head and neck cancer (HNC) [abstract 6034] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6034
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Choong, N.W.1    Haraf, D.J.2    Cohen, E.E.3    Stenson, K.M.4    Blair, E.A.5    Dekker, A.6    Williams, R.7    Karrison, T.G.8    Vokes, E.E.9
  • 42
    • 36049031069 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed (P) and bevacizumab (B) in patients (pts) with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC): An interim analysis
    • [abstract 6049] June 20 Supplement 6049
    • Karamouzis MV, Friedland D, Johnson R, Rajasenan K, Branstetter B, Argiris A: Phase II trial of pemetrexed (P) and bevacizumab (B) in patients (pts) with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC): An interim analysis [abstract 6049] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6049
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Karamouzis, M.V.1    Friedland, D.2    Johnson, R.3    Rajasenan, K.4    Branstetter, B.5    Argiris, A.6
  • 43
    • 36048982710 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN)
    • [abstract 6068] June 20 Supplement 6068
    • Savvides P, Greskovich J, Bokar J, Stepnick DW, Fu FJ, Patel C, Wasman J, Remick S, Lavertu P: Phase II study of bevacizumab in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN) [abstract 6068] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6068
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Savvides, P.1    Greskovich, J.2    Bokar, J.3    Stepnick, D.W.4    Fu, F.J.5    Patel, C.6    Wasman, J.7    Remick, S.8    Lavertu, P.9
  • 44
    • 36048978575 scopus 로고    scopus 로고
    • A phase II trial of sorafenib in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC): A Southwest Oncology Group (SWOG) trial
    • [abstract 6044] June 20 Supplement 6044
    • Williamson SK, Moon J, Huang CH, Guaglianone P, Wolf GT, Urba SG: A phase II trial of sorafenib in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC): A Southwest Oncology Group (SWOG) trial [abstract 6044] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6044
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Williamson, S.K.1    Moon, J.2    Huang, C.H.3    Guaglianone, P.4    Wolf, G.T.5    Urba, S.G.6
  • 47
    • 38149019804 scopus 로고    scopus 로고
    • An Open Label, Multi-Center, Phase I Study To Assess The Maximum Tolerated Dose of ZD6474 (ZACTIMA) Given Concomitantly With Radiation Therapy or Concomitantly With Weekly Cisplatin Chemotherapy and Radiation Therapy in Patients With Previously Untreated, Unresected, Stage III-IV Head and Neck Squamous Cell Carcinoma (NCT00411710). M. D. Anderson Cancer Center
    • An Open Label, Multi-Center, Phase I Study To Assess The Maximum Tolerated Dose of ZD6474 (ZACTIMA) Given Concomitantly With Radiation Therapy or Concomitantly With Weekly Cisplatin Chemotherapy and Radiation Therapy in Patients With Previously Untreated, Unresected, Stage III-IV Head and Neck Squamous Cell Carcinoma (NCT00411710). M. D. Anderson Cancer Center
  • 48
    • 26844452967 scopus 로고    scopus 로고
    • Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
    • Boccadoro M, Morgan G, Cavenagh J: Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int 2005, 5(1):18
    • (2005) Cancer Cell Int , vol.5 , Issue.1 , pp. 18
    • Boccadoro, M.1    Morgan, G.2    Cavenagh, J.3
  • 49
    • 38149024711 scopus 로고    scopus 로고
    • Phase II Two Arm Trial of the Proteasome Inhibitor, PS-341 (Velcade) in Combination With Irinotecan or PS-341 Alone Followed by the Addition of Irinotecan at Time Progression in Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (NCT00103259). Eastern Cooperative Oncology Group (ECOG)
    • Phase II Two Arm Trial of the Proteasome Inhibitor, PS-341 (Velcade) in Combination With Irinotecan or PS-341 Alone Followed by the Addition of Irinotecan at Time Progression in Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (NCT00103259). Eastern Cooperative Oncology Group (ECOG)
  • 50
    • 38149003577 scopus 로고    scopus 로고
    • A Phase I Study of Concomitant Therapy With Proteasome Inhibitor PS-341 and Radiation in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (NCT00016003). National Cancer Institute (NCI)
    • A Phase I Study of Concomitant Therapy With Proteasome Inhibitor PS-341 and Radiation in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (NCT00016003). National Cancer Institute (NCI)
  • 52
    • 38149113382 scopus 로고    scopus 로고
    • A Phase I Study of Weekly Low-Dose Cisplatin Plus Escalating Doses of Oral RAD001(Everolimus) for Patients With Advanced Solid Tumors (NCT00423865). Memorial Sloan-Kettering Cancer Center
    • A Phase I Study of Weekly Low-Dose Cisplatin Plus Escalating Doses of Oral RAD001(Everolimus) for Patients With Advanced Solid Tumors (NCT00423865). Memorial Sloan-Kettering Cancer Center
  • 53
    • 18844396087 scopus 로고    scopus 로고
    • Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo
    • Yin X, Zhang H, Burrows F, Zhang L, Shores CG: Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo. Clin Cancer Res 2005, 11(10):3889-3896
    • (2005) Clin Cancer Res , vol.11 , Issue.10 , pp. 3889-3896
    • Yin, X.1    Zhang, H.2    Burrows, F.3    Zhang, L.4    Shores, C.G.5
  • 54
    • 34147115929 scopus 로고    scopus 로고
    • A phase I open-label study to evaluate safety, tolerability and pharmacokinetic (PK) profile of VB4-845, an anti-EpCAM immunotoxin, in subjects with SCCHN
    • [abstract 5539] June 1 Supplement 5539
    • Quenneville J, Fitsialos D, Rasamoelisolo M, Cross M, Glover N, MacDonald G: A phase I open-label study to evaluate safety, tolerability and pharmacokinetic (PK) profile of VB4-845, an anti-EpCAM immunotoxin, in subjects with SCCHN [abstract 5539] J Clin Oncol, ASCO Ann Meet Proc 2005, 23(16S, Part I of II, June 1 Supplement):5539
    • (2005) J Clin Oncol, ASCO Ann Meet Proc , vol.23 , Issue.PART I of II
    • Quenneville, J.1    Fitsialos, D.2    Rasamoelisolo, M.3    Cross, M.4    Glover, N.5    MacDonald, G.6
  • 55
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden JE, Peart MJ, Johnstone RW: Anticancer activities of histone deacetylase inhibitors. Nat Rev 2006, 5(9):769-784
    • (2006) Nat Rev , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 56
    • 33847271170 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma
    • Slomiany MG, Black LA, Kibbey MM, Tingler MA, Day TA, Rosenzweig SA: Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma. Cancer Lett 2007, 248(2):269-279
    • (2007) Cancer Lett , vol.248 , Issue.2 , pp. 269-279
    • Slomiany, M.G.1    Black, L.A.2    Kibbey, M.M.3    Tingler, M.A.4    Day, T.A.5    Rosenzweig, S.A.6
  • 58
    • 38149136345 scopus 로고    scopus 로고
    • Prognostic significance of human papillomavirus (HPV) tumor status for patients with head and neck squamous cell carcinoma (HNSCC) in a prospective, multi-center phase II clinical trial
    • [abstract 6000] June 20 Supplement 6000
    • Fakhry C, Westra W, Li S, Cmelak A, Ridge J, Pinto H, Forastiere A, Gillison M: Prognostic significance of human papillomavirus (HPV) tumor status for patients with head and neck squamous cell carcinoma (HNSCC) in a prospective, multi-center phase II clinical trial [abstract 6000] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6000
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Fakhry, C.1    Westra, W.2    Li, S.3    Cmelak, A.4    Ridge, J.5    Pinto, H.6    Forastiere, A.7    Gillison, M.8
  • 59
    • 52349099810 scopus 로고    scopus 로고
    • Incidence trends for human papillomavirus-related (HPV-R) and unrelated (HPV-U) head and neck squamous cell carcinomas (HNSCC) in the United States (US)
    • [abstract 6001] June 20 Supplement 6001
    • Chaturvedi A, Engels E, Anderson W, Gillison M: Incidence trends for human papillomavirus-related (HPV-R) and unrelated (HPV-U) head and neck squamous cell carcinomas (HNSCC) in the United States (US) [abstract 6001] J Clin Oncol, ASCO Ann Meet Proc 2007, 25(18S, Part I, June 20 Supplement):6001
    • (2007) J Clin Oncol, ASCO Ann Meet Proc , vol.25 , Issue.PART I
    • Chaturvedi, A.1    Engels, E.2    Anderson, W.3    Gillison, M.4
  • 60
    • 38149089352 scopus 로고    scopus 로고
    • MAGE-A3/HPV 16 Peptide Based Immunotherapeutic Vaccines for Squamous Cell Carcinoma of the Head and Neck (NCT00257738). University of Maryland
    • MAGE-A3/HPV 16 Peptide Based Immunotherapeutic Vaccines for Squamous Cell Carcinoma of the Head and Neck (NCT00257738). University of Maryland


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