α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 694-699

  Ott, Gregory R ^a   Asakawa, Naoyuki ^a   Lu, Zhonghui ^a   Liu, Rui Qin ^a   Covington, Maryanne B ^a   Vaddi, Krishna ^a   Qian, Mingxin ^a   Newton, Robert C ^a   Christ, David D ^a   Traskos, James M ^a   Decicco, Carl P ^a   Duan, James J W ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

amino acid; Matrix metalloproteinase; MMP; TACE; TNF ; Tumor necrosis factor converting enzyme

Indexed keywords

ALPHA,BETA CYCLIC BETA BENZAMIDOHYDROXAMIC ACID DERIVATIVE; CYCLOPENTANE DERIVATIVE; CYCLOPENTANYL BETA BENZAMIDOHYDROXAMIC ACID; HYDROXAMIC ACID DERIVATIVE; LIPOPOLYSACCHARIDE; PYRROLIDINE DERIVATIVE; PYRROLIDINYL BETA BENZAMIDOHYDROXAMIC ACID; TETRAHYDROFURAN DERIVATIVE; TETRAHYDROFURANYL BETA BENZAMIDOHYDROXAMIC ACID; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; RAT;

ADAM PROTEINS; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; RATS; STEREOISOMERISM;

EID: 38149000234     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.059     Document Type: Article

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