Synthesis and characterization of chitosan-based biomaterials modified with different active groups and their relationship with cytotoxicity

Journal Wuhan University of Technology, Materials Science Edition

Volumn 22, Issue 4, 2007, Pages 695-700

  Lv, Yinghui ^a,b   Chen, Xiguang ^a   Wang, Qizhao ^a,b   Wang, Ye ^a   Zhang, Jing ^a   Liu, Chengsheng ^a   Liu, Chenguang ^a   Meng, Xianghong ^a   Yu, Lejun ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b HUAQIAO UNIVERSITY   (China)

Author keywords

Carboxymethylated chitosan (CMCH); Cytotoxicity; Deoxycholic acid modified chitosan (DACH); Linoleic acid modified chitosan (LACH)

Indexed keywords

BLOOD; CELL CULTURE; CYTOTOXICITY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS (CHEMICAL);

CARBOXYMETHYLATED-CHITOSAN (CMCH); LINOLEIC ACID MODIFIED-CHITOSAN (LACH);

BIOMATERIALS;

EID: 38049186679     PISSN: 10002413     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11595-006-4695-5     Document Type: Article

References (27)

1. Ouchi T, Nishizawa H, Ohya Y. Aggregation Phenomenon of PEG-grafted Chitosan in Aqueous Solution[J]. Polymer, 1998, 39(21):5171-5175
2. Holme K R, Perlin A S. Chitosan N-sulfate. A Water-soluble Polyelectrolyte[J]. Carbohyd. Res., 1997, 302(1-2):7-12
3. Krause T J, Goldsmith N K, Ebner S, et al. An Inhibitor of Cell Proliferation Associated with Adhesion Formation is Suppressed by N,O-carboxymethyl Chitosan[J]. J. Invest. Surg., 1998, 11(2):105-113
4. Uchegbu I F, Sadiq L, Arastoo M, et al. Quaternary Ammonium Palmitoyl Glycol Chitosan-a New Polysoap for Drug Delivery[J]. Int. J. Pharm., 2001, 224(1-2):185-199
5. Liu C G, Desai K G H, Chen X G, et al. Linolenic-Acid Modified Chitosan for Formation of Self-Assembled Nanoparticles[J]. J. Agr. Food. Chem., 2005, 53(2):437-441
6. Chen X G, Lee C M, Park H J. O/W Emulsification for the Self-aggregation and Nanoparticle Formation of Linoleic Acid Modified Chitosan in the Aqueous System[J]. J. Agr. Food. Chem., 2003, 51(10):3135-3139
7. Lee K Y, Kim Y H, Kwon I C, et al. Self-aggregates of Deoxycholic Acid-modified Chitosan as a Novel Carrier of Adriamycin[J]. Colloid. Polym. Sci., 2000, 278(12):1216-1219
8. Chen X G, Wang Z, Liu W S, et al. The Effect of Carboxymethyl-chitosan on Proliferation and Collagen Secretion of Normal and Keloid Skin Fibroblasts[J]. Biomaterials, 2002, 23(23):4609-4614
9. Kim K, Kwon S, Park J H, et al. Physicochemical Characterizations of Self-assembled Nanoparticles of Glycol Chitosan-deoxycholic Acid Conjugates[J]. Biomacromolecules, 2005, 6(2):1154-1158
10. Lee K Y, Known I C, Kim Y H, et al. Preparation of Chitosan Self-aggregates as a Gene Delivery System[J]. J. Control. Release., 1998, 51(2-3):213-220
11. Liu X F, Guan Y L, Yang D Z, et al. Antibacterial Action of Chitosan and Carboxymethylated Chitosan[J]. J. Appl. Polym. Sci., 2001, 79(7):1324-1335
12. Lee K Y, Jo W H, Kwon I C, et al. Structural Determination and Interior Polarity of Self-aggregates Prepared from Deoxycholic Acid-modified Chitosan in Water[J]. Macromolecules, 1998, 31:378-383
13. 13C NMR[J]. In.t. J. Biol. Macromol., 1992, 14(3):122-128
14. Parnham M J, Wetzig H. Toxicity Screening of Liposomes[J]. Chem. Phys. Lipids., 1993, 64(1-3):263-274
15. Hansen M B, Nielsen S E, BerK g. Re-examination and Further Development of a Precise and Rapid Dye Method for Measuring Cell Growth/Cell Kill[J]. J. Immunol. Methods, 1989, 119(2):203-210
16. Brugnerotto J, Lizardi J, Goycoolea F M, et al. An Infrared Investigation in Relation with Chitin and Chitosan Characterization[J]. Polymer., 2001, 42(8):3569-3580
17. Chen X G, Park H J. Chemical Characteristics of O-carboxymethyl Chitosans Related to the Preparation Conditions[J]. Carbohyd. Polym., 2003, 53(4):355-359
18. Ragnhild J, Hjerde N, Varum K M, et al. Chemical Composition of O-(carboxymethyl)-chitins in Relation to Lysozyme Degradation Rates[J]. Carbohyd. Polym., 1997, 34(3):131-139
19. Setchell K D R, Kritchevsky D, Nair P P. The Bile Acid: Chemistry, Physiology, and Metabolism. Volume 4: Methods and Applications[M]. New York: Plenum Press, 1988, 68
20. Rao S B, Sharma C P. Use of Chitosan as a Biomaterial: Studies on its Safety and Hemostatic Potential[J]. J. Biomed. Mater. Res., 1997, 34(1):21-28
21. Howling G I, Dettmar P W, Goddard P A, et al. The Effect of Chitin and Chitosan on the Proliferation of Human Skin Fibroblasts and Keratinosytes in vitro[J]. Biomaterials, 2001, 22(22):2959-2966
22. Fischer D, Li Y, Ahlemeyer B, et al. In vitro Cytotoxicity Testing of Polycations: Influence of Polymer Structure on Cell Viability and Hemolysis[J]. Biomaterials, 2003, 24(7):1121-1131
23. Quinton P M, Phillpot C W. A Role for Anionic Sites in Epithelial Architecture. Effect of Cationic Polymers on Cell Membrane Structure[J]. J. Cell. Biol., 1973, 56(3):787-796
24. Dekie L, Toncheva V, Dubruel P, et al. Poly-L-glutamic Acid Derivatives as Vectors for Gene Therapy[J]. J. Control. Rel., 2000, 65(1-2):187-202
25. Choksakulnimitr S, Masuda S, Tokuda H, et al. In vitro Cytotoxicity of Macromolecules in Different Cell Culture Systems[J]. J. Control. Rel., 1995, 34(3):233-241
26. Ryser H J. A Membrane Effect of Basic Polymers Dependent on Molecular Size[J]. Nature, 1967, 215(104):934-936
27. Hirano S, Noishiki Y, Kinugawa J. Chitin and Chitosan for use as Novel Biomedical Material[J]. Polym. Mater. Sci. Eng., 1985, 53:649-653