Production of cromolyn sodium microparticles for aerosol delivery by supercritical assisted atomization

AAPS PharmSciTech

Volumn 8, Issue 4, 2007, Pages

  Reverchon, Ernesto ^a   Adami, Renata ^a,b   Caputo, Giuseppe ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Atomization; Cromolyn sodium; Microparticles; Supercritical fluids

Indexed keywords

CROMOGLYCATE DISODIUM; ANTIASTHMATIC AGENT; WATER;

AEROSOL; ARTICLE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG MANUFACTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE ANALYSIS; LASER MICROSCOPY; NEBULIZATION; PARTICLE SIZE; RADIOGRAPHY; SCANNING ELECTRON MICROSCOPY; TEMPERATURE SENSITIVITY; THERMOGRAVIMETRY; VOLUMETRY; WATER CONTENT; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; DRUG STABILITY; EVALUATION; INHALATIONAL DRUG ADMINISTRATION; LASER; METHODOLOGY; PHARMACEUTICS; POWDER; PRECIPITATION; RADIATION SCATTERING; SUPERCRITICAL FLUID CHROMATOGRAPHY; SURFACE PROPERTY; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, INHALATION; AEROSOLS; ANTI-ASTHMATIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, SUPERCRITICAL FLUID; CROMOLYN SODIUM; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG STABILITY; LASERS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POWDERS; PRECIPITATION; SCATTERING, RADIATION; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; THERMOGRAVIMETRY; WATER;

EID: 38049170778     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0804114     Document Type: Article

References (29)

1. O'Neil MJ, Smith A, Heckelman PE, Budavari S, eds. The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th ed. New York, NY. John Wiley & Sons; 2001.
2. Reynolds J. Sodium Cromoglycate and Related Anti-Allergic Agents. London, UK: Pharmaceutical Press; 1989.
3. Hickey AJ. Inhalation Aerosols: Physical and Biological Basis for Therapy. New York, NY. Marcel Dekker, 1996.
4. Gonda I. Targeting by deposition. In: Hickey AJ, ed. Pharmaceutical Inhalation Aerosol Technology. New York, NY: Marcel Dekker; 1992:61-82.
5. Phillips EM, Stella VJ. Rapid expansion from supercritical solutions: application to pharmaceutical processes. Int J Pharm. 1993; 94:1-10.
6. Hanna M, York P, inventorsUniversity of Bradford. Method and apparatus for the formation of particles. World patent 9 501 221. January 12, 1995.
7. Shekunov BY, York P. Crystallization processes in pharmaceutical technology and drug delivery design. J Cryst Growth. 2000;211: 122-136.
8. Reverchon E. Supercritical antisolvent precipitation of micro- and nano-particles. J Supercrit Fluids. 1999;15:1-21.
9. Thiering R, Dehghani F, Foster NR. Current issues relating to anti-solvent micronisation techniques and their extension to industrial scales. J Supercrit Fluids. 2001;21:159-177.
10. Shariati A, Peters CJ. Recent developments in particle design using supercritical fluids. Curr Opin Solid State Mater Sci. 2003;7: 371-383.
11. Yeo SD, Kiran E. Formation of polymer particles with supercritical fluids: a review. J Supercrit Fluids. 2005;34:287-308.
12. Reverchon E, Adami R. Nanomaterials and supercritical fluids. J Supercrit Fluids. 2006;37:1-22.
13. Reverchon E. Supercritical-assisted atomization to produce micro- and/or nanoparticles of controlled size and distribution. Ind Eng Chem Res. 2002;41:2405-2411.
14. Reverchon E, Della Porta G. Terbutaline microparticles suitable for aerosol delivery produced by supercritical assisted atomization. Int J Pharm. 2003;258:1-9.
15. Reverchon E, Della Porta G, Spada A, Antonacci A. Griseofulvin micronization and dissolution rate improvement by supercritical assisted atomization. J Pharm Pharmacol. 2004;56:1379-1387.
16. Reverchon E, Adami R, Caputo G. Supercritical assisted atomization: performance comparison between laboratory and pilot scale. J Supercrit Fluids. 2006;37:298-306.
17. Della Porta G, De Vittori C, Reverchon E. Supercritical assisted atomization: a novel technology for microparticles preparation of an asthma-controlling drug. AAPS PharmSciTech [serial online]. 2005;6: E421-E428.
18. Jaarmo S, Rantakylä M, Aaltonen O. Particle tailoring with supercritical fluids: production of amorphous pharmaceutical particles. Proceedings of the 4th International Symposium on Supercritical Fluids, Vol A. 4th International Symposium on Supercritical Fluids; May 11-14; Sendai, Japan. Sendai, Japan: Tohoku University Press; 1997:263-266.
19. Rantakyla MJ. Particle Production by Superctitical Antisolvent Processing Techniques [thesis]. Helsinki, Finland: University of Technology, Helsinki (Espoo), Finland; 2004.
20. Radulovic D, Kocic-Pesic V, Pecanac D, Zivanovic L. HPLC determination of sodium chromoglycate in pharmaceutical dosage forms. Farmaco. 1994;49:375-376.
21. Lunn G, Schmuff NR. HPLC Methods for Pharmaceutical Analysis. New York, NY. NViley; 1997.
22. Chen LR Jr, Young VG Jr, Lechuga-Ballesteros D, Grant DJW. Solid-state behavior of cromolyn sodium hydrates. J Pharm Sci. 1999;88:1191-1200.
23. Stephenson GA, Diseroad BA. Structural relationship and desolvation behavior of cromolyn, cefazolin and fenoprofen sodium hydrates. Int J Pharm. 2000;198:161-177.
24. Najafabadi AR, Gilani K, Barghi M, Rafiee-Tehrani M. The effect of vehicle on physical properties and aerosolization behaviour of disodium cromoglycate microparticles spray dried alone or with L-leucine. Int J Pharm. 2004;285:97-108.
25. Cox JSG, Woodard GD, McCrone WC. Solid-state chemistry of cromolyn sodium (disodium cromoglycate). J Pharm Sci. 1971;60:1458-1465.
26. Reverchon E, Della Porta G, Spada A. Ampicillin micronization by supercritical assisted atomization. J Pharm Pharmacol. 2003;55: 1465-1471.
27. Reverchon E, Della Porta G. Micropization of antibiotics by supercritical assisted atomization. J Supercrit Fluids. 2003;26:243-252.
28. Reverchon E, Spada A. Erythromycin micro-particles produced by supercritical fluid atomization. Powder Technol. 2004;141:100-108.
29. Reverchon E, Antonacci A. Cyclodextrins micrometric powders obtained by supercritical fluid processing. Biotechnol Bioeng. 2006; 94:753-761.