Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF-κB

Respirology

Volumn 13, Issue 1, 2008, Pages 63-72

  Ou, Xue Mei ^a   Feng, Yu Ling ^a   Wen, Fu Qiang ^a   Wang, Ke ^a   Yang, Jie ^a   Deng, Zhi Pin ^a   Liu, Dai Shun ^a   Li, Yan Ping ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Airway; LPS; Macrolide; Mucus; NF B

Indexed keywords

AMOXICILLIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; JOSAMYCIN; LECTIN; LIPOPOLYSACCHARIDE; MACROLIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUCIN; MUCIN 5AC; ROXITHROMYCIN; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOPLASM; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; LUNG LAVAGE; MALE; MUCUS SECRETION; NEUTROPHIL COUNT; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; UPREGULATION; WESTERN BLOTTING;

AMOXICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; JOSAMYCIN; LIPOPOLYSACCHARIDES; MALE; MUCINS; MUCUS; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MUCOSA; RNA, MESSENGER; ROXITHROMYCIN;

EID: 38049153039     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2007.01213.x     Document Type: Article

References (42)

1. Rose MC, Nickola TJ, Voynow JA. Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. Am. J. Respir. Cell Mol. Biol. 2001 25 : 533 7.
2. Lange P, Nyboe J, Appleyard M, Jensen G, Schnohr P. Relation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease and from all causes. Thorax 1990 45 : 579 85.
3. Ichikawa Y, Ninomiya H, Koga H, Tanaka M, Kinoshita M et al. Erythromycin reduces neutrophils and neutrophil-derived elastolytic-like activity in the lower respiratory tract of bronchiolitis patients. Am. Rev. Respir. Dis. 1992 146 : 196 203.
4. Sakito O, Kadota J, Kohno S, Abe K, Shirai R et al. Interleukin 1 beta, tumor necrosis factor alpha, and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis: a potential mechanism of macrolide therapy. Respiration 1996 63 : 42 8.
5. Oishi K, Sonoda F, Kobayashi S, Iwagaki A, Nagatake T et al. Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases. Infect. Immun. 1994 62 : 4145 52.
6. Tagaya E, Tamaoki J, Kondo M, Nagai A. Effect of a short course of clarithromycin therapy on sputum production in patients with chronic airway hypersecretion. Chest 2002 122 : 213 8.
7. Suez D, Szefler SJ. Excessive accumulation of mucus in children with asthma: a potential role for erythromycin? A case discussion. J. Allergy Clin. Immunol. 1986 77 : 330 4.
8. Willey RF, Gould JC, Grant IW. A comparison of ampicillin, erythromycin and erythromycin with sulphametopyrazine in the treatment of infective exacerbations of chronic bronchitis. Br. J. Dis. Chest 1978 72 : 13 20.
9. Rubin BK, Henke MO. Immunomodulatory activity and effectiveness of macrolides in chronic airway disease. Chest 2004 125 : 70S 78S.
10. Takeshita K, Yamagishi I, Harada M, Otomo S, Nakagawa T et al. Immunological and anti-inflammatory effects of clarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages. Drugs Exp. Clin. Res. 1989 15 : 527 33.
11. Hand WL, Hand DL, King-Thompson NL. Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes. Antimicrob. Agents Chemother. 1990 34 : 863 70.
12. Mikasa K, Kita E, Sawaki M, Kunimatsu M, Hamada K et al. The anti-inflammatory effect of erythromycin in zymosan-induced peritonitis of mice. J. Antimicrob. Chemother. 1992 30 : 339 48.
13. Ichiyama T, Nishikawa M, Yoshiytomi T. Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells. Antimicrob. Agents Chemother. 2001 45 : 44 7.
14. Inamura K, Ohta N, Fukase S, Kasajima N, Aoyagi M. The effects of erythromycin on human peripheral neutrophil apoptosis. Rhinology 2000 38 : 124 9.
15. Noma T, Sugawara Y, Fujiwara S, Ogawa N, Kawano Y et al. Effect of roxithromycin on induction of apoptosis in peripheral blood lymphocytes from patients with bronchial asthma. Jpn. J. Antibiot. 2001 54 (Suppl. A 148 52.
16. Nelson S, Summer WR, Terry PB, Warr GA, Jakab GJ. Erythromycin-induced suppression of pulmonary antibacterial defenses. A potential mechanism of superinfection in the lung. Am. Rev. Respir. Dis. 1987 136 : 1207 12.
17. Labro MT, Benna J, Babin-Chevaye C. Comparison of the in-vitro effect of several macrolides on the oxidative burst of human neutrophils. J. Antimicrob. Chemother. 1989 24 : 561 72.
18. Culic O, Erakovic V, Parnham MJ. Anti-inflammatory effects of macrolide antibiotics. Eur. J. Pharmacol. 2001 429 : 209 29.
19. Tamaoki J. The effects of macrolides on inflammatory cells. Chest 2004 125 : 41S 51S.
20. Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y. In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Am. J. Respir. Crit. Care Med. 2003 168 : 581 7.
21. Kim DY, Takeuchi K, Ishinaga H, Kishioka C, Suzuki S et al. Roxithromycin suppresses mucin gene expression in epithelial cells. Pharmacology 2004 72 : 6 11.
22. 2u purinoceptor regulation of mucin secretion in SPOC1 cells, a goblet cell line from the airways. Biochem. J. 1996 316 : 943 51.
23. Singer M, Lefort J, Vargaftig BB. Granulocyte depletion and dexamethasone differentially modulate airways hyperreactivity, inflammation, mucus accumulation, and secretion induced by rmIL-13 or antigen. Am. J. Respir. Cell Mol. Biol. 2002 26 : 74 84.
24. Yanagihara K, Seki M, Cheng PW. Lipopolysaccharide induces mucus cell metaplasia in mouse lung. Am. J. Respir. Cell Mol. Biol. 2001 24 : 66 73.
25. Xing Z, Jordana M, Gauldie J, Wang J. Cytokines and pulmonary inflammatory and immune diseases. Histol. Histopathol. 1999 14 : 185 201.
26. Lynch EL, Little FF, Wilson KC, Center DM, Cruikshank WW. Immunomodulatory cytokines in asthmatic inflammation. Cytokine Growth Factor Rev. 2003 14 : 489 502.
27. Higgins GC, Foster JL, Postlethwaite AE. Interleukin 1 beta propeptide is detected intracellularly and extracellularly when human monocytes are stimulated with LPS in vitro. J. Exp. Med. 1994 180 : 607 14.
28. Lin G, Pearson AE, Scamurra RW, Zhou Y, Baarsch MJ et al. Regulation of interleukin-8 expression in porcine alveolar macrophages by bacterial lipopolysaccharide. J. Biol. Chem. 1994 269 : 77 85.
29. Ohtsuka H, Ohki K, Tanaka T, Tajima M, Yoshino T et al. Circulating tumor necrosis factor and interleukin-1 after administration of LPS in adult cows. J. Vet. Med. Sci. 1997 59 : 927 9.
30. Kunkel SL, Standiford T, Kasahara K, Strieter RM. Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung. Exp. Lung Res. 1991 17 : 17 23.
31. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur. Respir. J. Suppl. 2001 34 : 50s 59s.
32. Anderson BO, Brown JM, Bensard DD, Grosso MA, Banerjee A et al. Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms. Surgery 1990 108 : 262 7.
33. Kishi M, Richard LF, Webster RO, Dahms TE. Role of neutrophils in xanthine/xanthine oxidase-induced oxidant injury in isolated rabbit lungs. J. Appl. Physiol. 1999 87 : 2319 25.
34. Kawabata K, Hagio T, Matsuoka S. The role of neutrophil elastase in acute lung injury. Eur. J. Pharmacol. 2002 451 : 1 10.
35. Sheridan BC, McIntyre RC Jr, Moore EE, Meldrum DR, Agrafojo J et al. Neutrophils mediate pulmonary vasomotor dysfunction in endotoxin-induced acute lung injury. J. Trauma 1997 42 : 391 6.
36. Breyer I, Vulcano M, Alves Rosa MF, Isturiz MA. Human polymorphonuclear neutrophils (PMN) induce lipopolysaccharide (LPS) liberation from gram-negative bacteria. Medicina (B Aires) 1998 58 : 61 4 (in Spanish).
37. Gegner JA, Ulevitch RJ, Tobias PS. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J. Biol. Chem. 1995 270 : 5320 5.
38. An H, Xu H, Yu Y, Zhang M, Qi R et al. Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways. Immunol. Lett. 2002 81 : 165 9.
39. Adcock IM. Transcription factors as activators of gene transcription: AP-1 and NF-kappa B. Monaldi Arch. Chest Dis. 1997 52 : 178 86.
40. Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell Biol. 1999 19 : 5785 99.
41. Schulta MJ, Speelman P. Erythromycin inhibits Pseudomonas aeruginosa-induced tumor necrosis factor-alpha production in human whole blood. J. Antimicrob. Chemother. 2001 48 : 275 8.
42. Hippenstiel S, Soeth S, Kellas B, Fuhrmann O, Seybold J et al. Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells. Blood 2000 95 : 3044 51.