Aminotransferases are associated with insulin resistance and atherosclerosis in rheumatoid arthritis

BMC Cardiovascular Disorders

Volumn 7, Issue , 2007, Pages

  Dessein, Patrick H ^a,b   Woodiwiss, Angela J ^a   Joffe, Barry I ^a   Norton, Gavin R ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b MILPARK HOSPITAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; AZATHIOPRINE; CHLOROQUINE; FOLIC ACID; LEFLUNOMIDE; METHOTREXATE; MINOCYCLINE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; SALAZOSULFAPYRIDINE; ANTIRHEUMATIC AGENT;

ADULT; AGE DISTRIBUTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; DISEASE ASSOCIATION; DRUG INTERACTION; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; HUMAN; HYPERTENSION; HYPOTHYROIDISM; INSULIN RESISTANCE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; RISK FACTOR; SEX RATIO; ABDOMINAL FAT; BIOLOGICAL MODEL; BLOOD; CARDIOVASCULAR DISEASE; CAROTID ARTERY DISEASE; COHORT ANALYSIS; COMPARATIVE STUDY; ECHOGRAPHY; ENZYMOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; RISK; STATISTICAL MODEL; UPREGULATION;

ABDOMINAL FAT; ALANINE TRANSAMINASE; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; ASPARTATE AMINOTRANSFERASES; CARDIOVASCULAR DISEASES; CAROTID ARTERY DISEASES; COHORT STUDIES; FEMALE; HUMANS; INSULIN RESISTANCE; LOGISTIC MODELS; MALE; METHOTREXATE; MIDDLE AGED; MODELS, BIOLOGICAL; ODDS RATIO; RISK ASSESSMENT; RISK FACTORS; UP-REGULATION;

EID: 38049129055     PISSN: None     EISSN: 14712261     Source Type: Journal    
DOI: 10.1186/1471-2261-7-31     Document Type: Article

References (45)

1. Eckel RH Grundy SM Zimmet PZ The metabolic syndrome Lancet 2005, 365:1415-1428. 10.1016/S0140-6736(05)66378-7 15836891
2. American Heart Association National Heart, Lung, and Blood Institute Grundy SM Cleeman JI Daniels SR Donato KA Eckel RH Franklin BA Gordon DJ Krauss RM Savage PJ Smith SC Jr Spertus JA Costa F Diagnosis and management of the metabolic syndrome. An American Heart Association/ National Heart, Lung, and Blood Institute Scientific Statement. Executive Summary Cardiol Rev 2005, 13(6):322-327. 16708441
3. Yip J Facchini FS Reaven GM Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease J Clin Endocrinol Metab 1998, 83:2773-2776. 10.1210/jc.83.8.2773 9709945
4. Hanley AJ Williams K Stern MP Haffner SM Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: The San Antonio Heart Study Diabetes Care 2002, 25:1177-1184. 10.2337/diacare.25.7.1177 12087016
5. Hedblad B Nilsson P Engstrom G Berglund G Janzon L Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death Diabet Med 2007, 19:470-475. 10.1046/ j.1464-5491.2002.00719.x
6. Bonora E Kiechl S Willeit J Oberhollenzer F Egger G Meigs JB Bonadonna RC Muggeo M Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in Caucasian subjects from the general population Diabetes Care 2007, 30:318-324. 10.2337/dc06-0919 17259501
7. Reilly MP Wolfe ML Rhodes T Girman C Mehta N Rader DJ Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis Circulation 2004, 110:803-809. 10.1161/01.CIR.0000138740.84883.9C 15289378
8. Solomon DH Karlson EW Rimm EB Cannuscio CC Mandl LA Manson JE Stampfer MJ Curhan GC Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis Circulation 2003, 107:1303-1307. 10.1161/ 01.CIR.0000054612.26458.B2 12628952
9. Maradit-Kremers H Nicola PJ Crowson CS Ballman KV Gabriel SE Cardiovascular death in rheumatoid arthritis: A population-based study Arthritis Rheum 2005, 52:722-732. 10.1002/art.20878 15751097
10. Goodson N Marks J Lunt M Symmons D Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s Ann Rheum Dis 2005, 64:1595-1601. 10.1136/ard.2004.034777 15843450
11. Sattar N McCarey DW Capell H McInnes IB Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis Circulation 2003, 108:2957-2963. 10.1161/ 01.CIR.0000099844.31524.05 14676136
12. Gonzalez-Gay MA Gonzalez-Juanatey C Martin J Rheumatoid arthritis: A disease associated with accelerated atherogenesis Semin Arthritis Rheum 2005, 35:8-17. 10.1016/j.semarthrit.2005.03.004 16084219
13. Gonzalez-Gay MA De Matias JM Gonzalez-Juanatey C Garcia-Porrua C Sanchez-Andrade A Martin J Llorca J Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis Clin Exp Rheumatol 2006, 24:83-86. 16539824
14. Dessein PH Stanwix AE Joffe BI Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: Acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis Arthritis Res 2002, 4:R5. 125299 12223108 10.1186/ar428
15. Dessein PH Joffe BI Stanwix AE Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: A pilot study Arthritis Res 2002, 4:R12. 153842 12453315 10.1186/ar597
16. Dessein PH Tobias M Veller MG Metabolic syndrome and subclinical atherosclerosis in rheumatoid arthritis J Rheumatol 2006, 33:2425-2432. 17080519
17. Chung CP Oeser A Solus JF Avalos I Gebretsadik T Shintani A Raggi P Sokka T Pincus T Stein CM Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis Atherosclerosis 2007 [Epub ahead of print]
18. Alberti KGMM Zimmet P Shaw J The metabolic syndrome-a new worldwide definition Lancet 2005, 366:1059-1062. 10.1016/S0140-6736(05)67402-8 16182882
19. Grundy SM Cleeman JI Daniels SR Donato KA Eckel RH Franklin BA Gordon DJ Krauss RM Savage PJ Smith SC Jr Spertus JA Costa F Diagnosis and management of the metabolic syndrome: An American Heart Association/ National Heart, Lung, and Blood Institute Scientific Statement Circulation 2005, 112:2735-2752. 10.1161/CIRCULATIONAHA.105.169404 16157765
20. Angulo P Nonalcoholic fatty liver disease N Engl J Med 2002, 346:1221-1231. 10.1056/NEJMra011775 11961152
21. Yki-Jarvinen H Fat in the liver and insulin resistance Ann Med 2005, 37:347-356. 10.1080/07853890510037383 16179270
22. Westerbacka J Corner A Tiikkainen M Tamminen M Vehkavaara S Hakkinen AM Fredriksson J Yki-Jarvinen H Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk Diabetologia 2004, 47:1360-1369. 10.1007/s00125-004-1460-1 15309287
23. Clark JM Brancati FL Diehl AM The prevalence and etiology of elevated aminotransferase levels in the United States Am J Gastroenterol 2003, 98:960-967. 10.1111/j.1572-0241.2003.07486.x 12809815
24. Schindhelm RK Dekker JM Nijpels G Bouter LM Stehouwer CDA Heine RJ Diamant M Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study Atherosclerosis 2007, 191(2):391-396. 10.1016/j.atherosclerosis.2006.04.006 16682043
25. Arnett FC Edworthy SM Bloch DA McShane DJ Fries JF Cooper NS The American Rheumatology Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324. 10.1002/art.1780310302 3358796
26. Andrews NC Disorders of iron metabolism N Engl J Med 1999, 341:1986-1995. 10.1056/NEJM199912233412607 10607817
27. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 2005, 28:537-542. 10.2337/diacare.28.5.1245
28. Dessein PH Joffe BI Veller MG Stevens BA Tobias M Reddy K Stanwix AE Traditional and nontraditional cardiovascular risk factors are associated with atherosclerosis in rheumatoid arthritis J Rheumatol 2005, 32:435-442. 15742434
29. Wallace TM Levy JC Matthews DR Use and abuse of HOMA modeling Diabetes Care 2004, 27:1487-1495. 10.2337/diacare.27.6.1487 15161807
30. Peduzzi P Concato J Kemper E Holford TR Feinstein AR A simulation study of the number of events per variable in logistic regression analysis J Clin Epidemiol 1996, 49:1371-1379. 10.1016/S0895-4356(96)00236-3
31. del Rincon I Williams K Stern MP Freeman GL O'Leary DH Escalante A Association between carotid atherosclerosis and markers of inflammation in rheumatoid arthritis patients and healthy subjects Arthritis Rheum 2003, 48:1833-1840. 10.1002/art.11078 12847676
32. del Rincon I Freeman GL Haas RW O'Leary DH Escalante A Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis Arthritis Rheum 2005, 52:3413-3423. 10.1002/art.21397 16255018
33. Siest G Study of reference values and biological variation: A necessity and a model for Preventive Medicine Centers Clin Chem Lab Med 2004, 42:810-816. 10.1515/CCLM.2004.134 15327017
34. Saha B Maity C Alteration of serum enzymes in primary hypothyroidism Clin Chem Lab Med 2002, 40:609-611. 10.1515/CCLM.2002.105 12211657
35. Chang Y Ryu S Sung E Jang Y Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease Clin Chem 2007, 53:686-692. 10.1373/ clinchem.2006.081257 17272484
36. Kerner A Avizohar O Sella R Bartha P Zinder O Markiewicz W Levy Y Brook GJ Aronson D Association between elevated liver enzymes and C-reactive protein: Possible hepatic contribution to systemic inflammation in the metabolic syndrome Arterioscler Thromb Vasc Biol 2005, 25(1):193-197. 15499043
37. Yamada J Tomiyama H Yambe M Koji Y Motobe K Shiina K Yamamoto Y Yamashina A Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome Atherosclerosis 2006, 189:198-205. 10.1016/j.atherosclerosis.2005.11.036 16405892
38. den Boer M Voshol PJ Kuipers F Havekes LM Romijn JA Hepatic steatosis: A mediator of the metabolic syndrome. Lessons from animal models Arterioscler Thromb Vasc Biol 2004, 24:644-649. 10.1161/ 01.ATV.0000116217.57583.6e 14715643
39. Prati D Taioli E Zanella A Della Torre E Butelli S Del Vecchio E Vianella L Zanuso F Mozzi F Milani S Conte D Colombo M Sirchia G Updated definitions of healthy ranges for serum alanine aminotransferase levels Ann Intern Med 2002, 137:1-9. 12093239
40. Kahn R Buse J Ferrannini E Stern M American Diabetes Association: European Association for the Study of Diabetes. The metabolic syndrome: time for a critical appraisal Diabetes Care 2005, 28:2289-2304. 10.2337/ diacare.28.9.2289 16123508
41. Choi HK Heman MA Seeger JD Robins JM Wolfe F Methotrexate and mortality in patients with rheumatoid arthritis: A prospective study Lancet 2002, 359:1173-1177. 10.1016/S0140-6736(02)08213-2 11955534
42. Ellis LA Brown D Conradie JD Paterson A Sher R Millo J Theodossiadou E Dusheiko GM Prevalence of hepatitis C in South Africa: Detection of anti-HCV in recent and stored serum J Med Virol 1990, 32:249-251. 10.1002/jmv.1890320410 2127942
43. Veller MG Fisher CM Nicolaides AN Renton S Geroulakos G Stafford MJ Sarker A Szendro G Belcaro G Measurement of the ultrasonic intima-media complex thickness in normal subjects J Vasc Surg 1993, 17:719-725. 10.1067/mva.1993.41133 8464091
44. Dessein PH Norton GR Woodiwiss AJ Joffe BI Wolfe F Impact of non-classical cardiovascular risk factors on the accuracy of predicting subclinical atherosclerosis in rheumatoid arthritis J Rheumatol 2007, 34:943-951. 17444592
45. Roman MJ Moeller E Davis A Paget SA Crow MK Lockshin MD Sammaritano L Devereux RB Schwartz JE Levine DM Salmon JE Preclinical carotid atherosclerosis in patients with rheumatoid arthritis Ann Intern Med 2006, 144:249-256. 16490910