Molecular modeling and site directed mutagenesis of the O-methyltransferase, SOMT-9 reveal amino acids important for its reaction and regioselectivity

Bulletin of the Korean Chemical Society

Volumn 28, Issue 12, 2007, Pages 2248-2252

  So, Hyun Park ^a   Bong, Gyu Kim ^a   Sun, Hee Lee ^a   Lim, Yoongho ^a   Cheong, Youhoon ^a   Ahn, Joong Hoon ^a  

^a Konkuk University   (South Korea)

Author keywords

Molecular modeling; O methyltransferase; Quercetin; Site directed mutagenesis

Indexed keywords

MOLECULAR MODELING; MUTAGENESIS; REGIOSELECTIVITY;

ADOMET BINDING; METAL BINDING; MOLECULAR DOCKING; QUERCETIN;

AMINO ACIDS;

EID: 38049121659     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2007.28.12.2248     Document Type: Article

References (16)

1. Ibrahim, R. K.; Bruneau, A.; Bantignies, B. Plant Mol. Biol. 1988, 36, 1.
2. Joshi, C. P.; Chiang, V. L. Plant Mol. Biol. 1998, 37, 663.
3. Ibdah, M.; Zhang, X.-H.; Schnot, J.; Vogt, T. J. Biol. Chem. 2003, 278, 43961.
4. Kim, B. G.; Shin, K. H.; Lee, Y.; Hur, H.-G.; Lim, Y.; Ahn, J.-H. Biotechnol. Lett. 2005, 27, 1861.
5. Kim, B. G.; Lee, Y.; Hur, H.-G.; Lim, Y.; Ahn, J.-H. Phytochemistry 2006, 67, 387.
6. Kim, B. G.; Kim, H.; Kim, J.-H.; Lim, Y.; Ahn, J.-H. Bull. Korean Chem. Soc. 2006, 27, 357.
7. Kim, B. G.; Lee, Y.; Hur, H. G.; Lim, Y.; Ahn, J.-H. Biosci. Biotech. Biochem. 2006, 70, 1269.
8. Kim, J. H.; Kim, B. G.; Park, Y.; Han, J. H.; Lim, Y.; Ahn, J.-H. Agric. Chem. Biotechnol. 2006, 49, 114.
9. Zubieta, C.; Kota, P.; Ferrer, J.-L.; Dixon, R. F.; Noel, J. P. Plant Cell 2002, 14, 1265.
10. Zubieta, C.; He, X.-Z.; Dixon, R. F.; Noel, J. P. Nature Stru. Biol. 2001, 8, 271.
11. Ferrer, F.-L.; Zubieta, C.; Dixon, R. A.; Noel, J. P. Plant Physiol. 2005, 137, 1009.
12. Yang, H.; Ahn, J.-H.; Jeong, K. J.; Lee, S.; Lim, Y. Bull. Korean Chem. Soc. 2003, 24, 1.
13. Yang, H.; Ahn, J.-H.; Ibrahim, R. K.; Lee, S.; Lim, Y. J. Mol. Model. 2004, 23, 77.
14. Lee, J.-Y.; Lee, S.-A.; Kim, Y. Bull. Korean Chem. Soc. 2007, 28, 941.
15. Kim, B. G.; Lee, H. J.; Park, Y.; Lim, Y.; Ahn, J.-H. Plant Physiol. Biochem. 2006, 44, 236.
16. Laskowski, R. A.; MacArthur, M. W.; Moss, D. S.; Thornton, J. M. J. Appl. Cryst. 1993, 26, 1647.