Dose-dependent inhibition of allergic inflammation and bronchial hyperresponsiveness by budesonide in ovalbumin-sensitised Brown-Norway rats

Pulmonary Pharmacology and Therapeutics

Volumn 21, Issue 1, 2008, Pages 98-104

  Leung, Sum Yee ^a   Williams, Alison S ^a   Nath, Puneeta ^a   Dinh, Q Thai ^a   Oates, Timothy ^a   Blanc, F Xavier ^a   Eynott, Paul R ^a   Chung, Kian Fan ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Airway inflammation; Asthma; Bronchial hyperresponsiveness; Budesonide

Indexed keywords

BUDESONIDE; GLUCOCORTICOID; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRONCHUS HYPERREACTIVITY; BROWN NORWAY RAT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EOSINOPHIL; EOSINOPHIL COUNT; EOSINOPHILIA; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; RESPIRATORY TRACT MUCOSA; SENSITIZATION; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

ACETYLCHOLINE; ANIMALS; BLOOD CELL COUNT; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; BUDESONIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOCORTICOIDS; HYPERSENSITIVITY; MALE; OVALBUMIN; RATS;

EID: 38049094902     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2007.01.001     Document Type: Article

References (32)

1. Djukanovic R., Wilson J.W., Britten K.M., Wilson S.J., Walls A.F., Roche W.R., et al. Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis 142 (1990) 863-871
2. Chung K.F., Aizawa H., Leikauf G.D., Ueki I.F., Evans T.W., and Nadel J.A. Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. J Pharmacol Exp Ther 236 (1986) 580-584
3. Behrens B.L., Clark R.A., Marsh W., and Larsen G.L. Modulation of the late asthmatic response by antigen-specific immunoglobulin G in an animal model. Am Rev Respir Dis 130 (1984) 1134-1139
4. Reid L.M. Needs for animal models of human diseases of the respiratory system. Am J Pathol 101 (1980) S89-S101
5. Wanner A. Utility of animal models in the study of human airway disease. Chest 98 (1990) 211-217
6. Elwood W., Lotvall J.O., Barnes P.J., and Chung K.F. Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized Brown-Norway rats. J Allergy Clin Immunol 88 (1991) 951-960
7. Huang T.J., Newton R., Haddad E.B., and Chung K.F. Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 104 (1999) 644-652
8. Eum S.Y., Creminon C., Haile S., Lefort J., and Vargaftig B.B. Inhibition of airways inflammation by dexamethasone is followed by reduced bronchial hyperreactivity in BP2 mice. Clin Exp Allergy 26 (1996) 971-979
9. Trifilieff A., El Hashim A., and Bertrand C. Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment. Am J Physiol Lung Cell Mol Physiol 279 (2000) L1120-L1128
10. Matsubara S., Fushimi K., Kikkawa H., Naito K., and Ikezawa K. Difference in inhibitory effects of dexamethasone and cyclosporin A on Sephadex bead-induced airway hyperresponsiveness and inflammation in rats. Jpn J Pharmacol 77 (1998) 89-98
11. Birrell M.A., Battram C.H., Woodman P., McCluskie K., and Belvisi M.G. Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways. Respir Res 4 (2003) 3
12. Tigani B., Hannon J.P., Schaeublin E., Mazzoni L., and Fozard J.R. Effects of immunomodulators on airways hyperresponsiveness to adenosine induced in actively sensitised Brown Norway rats by exposure to allergen. Naunyn Schmiedebergs Arch Pharmacol 368 (2003) 17-25
13. Haczku A., Moqbel R., Elwood W., Sun J., Kay A.B., Barnes P.J., et al. Effects of prolonged repeated exposure to ovalbumin in sensitized Brown Norway rats. Am J Respir Crit Care Med 150 (1994) 23-27
14. Haczku A., Moqbel R., Jacobson M., Kay A.B., Barnes P.J., and Chung K.F. T-cells subsets and activation in bronchial mucosa of sensitized Brown-Norway rats after single allergen exposure. Immunology 85 (1995) 591-597
15. Gibson P.G., Saltos N., and Fakes K. Acute anti-inflammatory effects of inhaled budesonide in asthma: a randomized controlled trial. Am J Respir Crit Care Med 163 (2001) 32-36
16. Wilson S.J., Wallin A., Della-Cioppa G., Sandstrom T., and Holgate S.T. Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma. Am J Respir Crit Care Med 164 (2001) 1047-1052
17. Huang T.J., Eynott P., Salmon M., Nicklin P.L., and Chung K.F. Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats. Eur J Pharmacol 437 (2002) 187-194
18. Brattsand R., and Miller-Larsson A. The role of intracellular esterification in budesonide once-daily dosing and airway selectivity. Clin Ther 25 Suppl C (2003) C28-C41
19. Dahlback M., Bergstrand H., and Brattsand R. Antigen-induced bronchial anaphylaxis in actively sensitized SD rats. Effects of glucocorticoid treatment. Allergy 41 (1986) 210-219
20. Abraham W.M., Lanes S., Stevenson J.S., and Yerger L.D. Effect of an inhaled glucocorticosteroid (budesonide) on post-antigen induced increases in airway responsiveness. Bull Eur Physiopathol Respir 22 (1986) 387-392
21. Hayes J.P., Barnes P.J., Taylor A.J., and Chung K.F. Effect of a topical corticosteroid on airway hyperresponsiveness and eosinophilic inflammation induced by trimellitic anhydride exposure in sensitized guinea pigs. J Allergy Clin Immunol 92 (1993) 450-456
22. Woolley M.J., Wattie J., Ellis R., Lane C.G., Stevens W.H., Woolley K.L., et al. Effect of an inhaled corticosteroid on airway eosinophils and allergen-induced airway hyperresponsiveness in dogs. J Appl Physiol 77 (1994) 1303-1308
23. Haddad E., Underwood S.L., Dabrowski D., Birrell M.A., McCluskie K., Battram C.H., et al. Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification. J Immunol 168 (2002) 3004-3016
24. Xu L., Olivenstein R., Martin J.G., and Powell W.S. Inhaled budesonide inhibits OVA-induced airway narrowing, inflammation, and cys-LT synthesis in BN rats. J Appl Physiol 89 (2000) 1852-1858
25. Vanacker N.J., Palmans E., Pauwels R.A., and Kips J.C. Dose-related effect of inhaled fluticasone on allergen-induced airway changes in rats. Eur Respir J 20 (2002) 873-879
26. Kelly E.A., Busse W.W., and Jarjour N.N. Inhaled budesonide decreases airway inflammatory response to allergen. Am J Respir Crit Care Med 162 (2000) 883-890
27. Deleuze V., Lefort J., Bureau M.F., Scherman D., and Vargaftig B.B. LPS-induced bronchial hyperreactivity: interference by mIL-10 differs according to site of delivery. Am J Physiol Lung Cell Mol Physiol 286 (2004) L98-L105
28. Vincent D., Lefort J., Bureau M., Dry J., and Vargaftig B.B. Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. Agents Actions 34 (1991) 203-204
29. Pare P.D. Airway hyperresponsiveness in asthma: geometry is not everything!. Am J Respir Crit Care Med 168 (2003) 913-914
30. Fernandes D.J., Mitchell R.W., Lakser O., Dowell M., Stewart A.G., and Solway J. Invited review: do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?. J Appl Physiol 95 (2003) 844-853
31. Taube C., Nick J.A., Siegmund B., Duez C., Takeda K., Rha Y.H., et al. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. Am J Respir Cell Mol Biol 30 (2004) 837-843
32. Taylor B.M., Kolbasa K.P., Chin J.E., Richards I.M., Fleming W.E., Griffin R.L., et al. Roles of adhesion molecules ICAM-1 and alpha 4 integrin in antigen-induced changes in microvascular permeability associated with lung inflammation in sensitized Brown Norway rats. Am J Respir Cell Mol Biol 17 (1997) 757-766