A straightforward protocol for the solution-phase parallel synthesis of ceramide analogues

European Journal of Organic Chemistry

Volumn , Issue 1, 2008, Pages 150-155

  Grijalvo, Santiago ^a,b   Matabosch, Xavier ^a   Llebaria, Amadeu ^a   Delgado, Antonio ^a,b  

^a DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Amino alcohols; Ceramide analogues; Combinatorial chemistry; Scavengers; Supported reagents

Indexed keywords

EID: 38049086665     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200700814     Document Type: Article

References (17)

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14. When required, traces of unreacted starting amine were removed with the acidic resin Amberlyte IR120 hydrogen form (Aldrich, ref 216534) as follows: A solution of the corresponding ceramide analogue in MeOH (2.0 mL) was treated with Amberlyte IR120 (100 mg, equivalent to 0.4 mmol based on resin loading) and stirred overnight at room temperature. The resin was filtered out, and the solution was evaporated to dryness to afford the required ceramide analogues.
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