The toxicity of Senecio inaequidens DC

Journal of the South African Veterinary Association

Volumn 78, Issue 3, 2007, Pages 121-129

  Dimande, A F P ^a   Botha, Christo J ^a   Prozesky, L ^a   Bekker, L ^a   Rosemann G M ^a   Labuschagne, L ^b   Retief, E ^c  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b ONDERSTEPOORT VETERINARY INSTITUTE   (South Africa)

^c SOUTH AFRICAN NATIONAL BIODIVERSITY INSTITUTE   (South Africa)

Author keywords

Cattle; Hepatotoxicity; Pyrrolizidine alkaloids; Rats; Senecio inaequidens; Sheep

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CREATININE; GAMMA GLUTAMYLTRANSFERASE; PLANT EXTRACT; PYRROLIZIDINE ALKALOID; RETRORSINE; SENECIO INAEQUIDENS EXTRACT; SENECIONINE; UNCLASSIFIED DRUG; UREA;

ANIMAL DISEASE; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CHEMICAL ANALYSIS; CLINICAL FEATURE; CONTROLLED STUDY; HISTOPATHOLOGY; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; PHYTOCHEMISTRY; PLANT INTOXICATION; RAT; SENECIO; SENECIO INAEQUIDENS; SHEEP; SOUTH AFRICA; TISSUE DISTRIBUTION; TOXICITY TESTING;

ANIMALIA; ASTERACEAE; BOS; HEDYOTIS MANNII; OVIS ARIES; RATTUS; SENECIO INAEQUIDENS;

ANIMAL FEED; ANIMALS; CATTLE; CATTLE DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; PLANT POISONING; PYRROLIZIDINE ALKALOIDS; RATS; RATS, SPRAGUE-DAWLEY; SENECIO; TOXICITY TESTS;

EID: 38049079184     PISSN: 10199128     EISSN: 22249435     Source Type: Journal    
DOI: 10.4102/jsava.v78i3.302     Document Type: Article

References (27)

1. Barros C S L, Driemer D, Pilati C, Barros S S, Castilhos L M L1992 Senecio poisoning in cattle in southern Brazil. Veterinary and Human Toxicology 34:241-246
2. Bicchi C, D'Amato A, Cappelletti E 1985 Determination of pyrrolizidine alkaloids in Senecio inaequidens DC. by capillary gas chromatography. Journal of Chromatography 349: 23-29
3. Cheeke P R 1998 Natural toxicants in feeds, forages and poisonous plants. (2nd edn). Interstate Publishers. Danville, Illinois
4. Craig A M, Pearson E G, Meyer C, Schmitz J A 1991 Serum liver enzyme and histopathology changes in calves with chronic and chronic-delayed Senecio jacobaea toxicosis. American Journal of Veterinary Research 52: 1969-1978
5. Craigmill A L 1981 Toxic plants II. Pyrrolizidine alkaloids. Cooperative Extension, University of California Environmental Toxicology Newsletter 1(4). http://extoxnet.orst.edu/newsletters/n14_81.htm
6. Elliot J R, Bain PJ, Latimer K S 2005 Pyrrolizidine alkaloid toxicity. College of Veterinary Medicine, University of Georgia. Athens, GA
7. European and Mediterranean Plant Protection (EPPO), 2006. Senecio inaequidens. Data sheet on invasive plants, http://www.eppo.org/ quarantine/plants/senecio-inaequidens/seniq-ds.pdf
8. Ghadially F N 1997 Ultrastructural pathology of the cell and matrix Vols 1, 2 (4th edn). Butterworth-Heinemann, Boston
9. Habermehel G G, Martz W, Tokarnia C H, Dobereiner J, Mendez M C 1988 Livestock poisoning in South America by species of the Senecio plant. Toxicon 26: 275-286
10. Johnson A E, Molineux R J 1984 Toxicity of thread leaf groundsel ( Senecio douglasii var longilobus) to cattle. American Journal of Veterinary Research 45: 26-31
11. Johnson A E, Molineux R J, Stuart L D 1985 Toxicity of riddell's groundsel (Senecio riddellii) to cattle. American Journal of Veterinary Research 46: 577-582
12. Karam F S C, Soares M P, Haraguchi M, Riet-Correa F, Méndez M C, Jerenkow J A 2004 Aspectos epidemiológicos da seneciosis na região sul do Rio Grande do Sul. Pesquisa Veterinária Brasileira 24: 191-198
13. Kellerman T S, Naudé T W, Fourie N 1996 The distribution and estimated economic impact of plant poisoning and mycotoxicoses in South Africa. Onderstepoort Journal of Veterinary Research 63: 65-90
14. Kellerman T S, Coetzer J A W, Naudé T W, Botha C J 2005 Plant poisonings and mycotoxicoses of livestock in Southern Africa. Oxford University Press, Cape Town
15. Lessard P, Wilson W D, Olander H J, Rogers Q R Mendel V E 1986 Clinicopathologic study of horses surviving pyrrolizidine alkaloid ( Senecio vulgaris) toxicosis. American Journal of Veterinary Research 47: 1776-80
16. Mattocks A R 1986 Chemistry and toxicology of pyrrolizidine alkaloids. Academic Press Inc., London
17. Molineux R J, Johnson E A, Olsen J D, Baker C D 1991 Toxicity of pyrrolizidine alkaloids from riddell groundsel (Senecio riddellii) to cattle. American Journal of Veterinary Research 52: 146-151
18. Pearson E G 1990 Pyrrolizidine alkaloid toxicity. In Smith B P (ed.) Large animal internal medicine. Diseases of horses, cattle, sheep and goats. The C V Molsby Company, St Louis: 850-852
19. Powrie L 2004 Common names of Karoo plants. Strelitzia 16. National Botanical Institute, Pretoria
20. Röder E, Wiedenfeld H, Stengl P 1981 Pyrrolizidine alkaloids senecionine and retrorsine from Senecio inaequidens. Planta Medica 41: 412-413
21. Rösemann G M 2007 Analysis of pyrrolizidine alkaloids in Crotalaria species by HPLC-MS/MS in order to evaluate related food risks. PhD thesis, University of Pretoria
22. Rzedowski J, Vibrans H, Rzedowski G C 2003 Senecio inaequidens DC. (Compositae, Senecioneae), una maleza prejudicial introducida en Mexico. Acta Botanica Mexicana 63: 83-96
23. Smith L W, Culvenor C C J 1981 Plant sources of hepatotoxic pyrrolizidine alkaloids. Journal of Natural Products 44: 129-52
24. Stegelmeier, B L, Edgar J A, Colegate S M, Gardner D R, Schoch T K, Coulombe, R A, Molineux R J 1999 Pyrrolizidine alkaloids in plants, metabolism and toxicity. Journal of Natural Toxins 8: 95-116
25. Van Wyk B, Malan S 1997 Field guide to the wild flowers of the Highveld. Struik, Cape Town
26. Wachenheim D E, Blythe L L, Craig A M 1992 Effects of antibacterial agents on in vitro ovine ruminal biotransformation of hepatotoxic pyrrilozidine alkaloid jacobine. Applied and Environmental Microbiology 58: 2559-2564
27. Wachenheim D E, Blythe L L, Craig A M 1992 Characterization of rumen bacterial pyrrolizidine alkaloid biotransformation in ruminants of various species. Veterinary and Human Toxicology 34: 513-517