Hepatic alteration of tryptophan metabolism in an acute porphyria model. Its relation with gluconeogenic blockage

Biochemical Pharmacology

Volumn 75, Issue 3, 2008, Pages 704-712

  Lelli, Sandra M ^a   Mazzetti, Marta B ^a   San Martín de Viale, Leonor C ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

2 Allyl 2 isopropylacetamide; 3,5 Diethoxycarbonyl 1,4 dihydrocollidine; Acute porphyria model; Phosphoenolpyruvate carboxykinase; Tryptophan metabolism; Tryptophan pyrrolase

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; 5 AMINOLEVULINATE SYNTHASE; ALLYLISOPROPYLACETAMIDE; FERROCHELATASE; HEME; KYNURENINE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PORPHOBILINOGEN; QUINOLINIC ACID; SEROTONIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRYPTOPHAN 2,3 DIOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; ENZYME ACTIVITY; FEMALE; GLUCONEOGENESIS; LIVER METABOLISM; LIVER MICROSOME METABOLISM; LIVER TOXICITY; NONHUMAN; PORPHYRIA; PRIORITY JOURNAL; RAT; SEROTONINERGIC TRANSMISSION; TRYPTOPHAN METABOLISM;

5-AMINOLEVULINATE SYNTHETASE; ACUTE DISEASE; ALLYLISOPROPYLACETAMIDE; ANIMALS; DICARBETHOXYDIHYDROCOLLIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCONEOGENESIS; LIVER; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PORPHYRIAS; RATS; RATS, WISTAR; TRYPTOPHAN;

EID: 38049056756     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.09.023     Document Type: Article

References (45)

1. Kappas A., Sassa S., Galbraith R.A., and Nordmann Y. The porphyrias. In: Scriver C.R., Beaudet A.L., Sly W.S., Valle D., Stanbury J.B., Wibgaarden J.B., and Fredickson D.S. (Eds). Metabolic and molecular basis of inherited disease (1995), McGraw-Hill, New York 2103-2159
2. Litman D.A., and Correia M.A. l-Tryptophan: a common denominator of biochemical and neurological events of acute hepatic porphyria?. Science 222 (1983) 1031-1033
3. Tschudy D.P. Clinical aspects of drug reactions in hereditary hepatic porphyria. Ann N Y Acad Sci 151 (1968) 850-860
4. Doss M., Sixel-Dietrich F., and Verspohl F. "Glucose effect" and rate limiting function of uroporphyrinogen synthase on porphyrin metabolism in hepatocyte culture: relationship with human acute hepatic porphyrias. J Clin Chem Clin Biochem 23 (1985) 505-513
5. Bonkowsky H.L. Porphyrin and heme metabolism and the porphyrias. In: Zakim D., and Boyer T.D. (Eds). Hepathology: a textbook of medicine (1982), Saunders, Philadelphia 352-396
6. Smith A.G., and De Matteis F. Drugs and hepatic porphyrias. Clin Haematol 9 (1980) 399-425
7. Ortiz de Montellano P.R., Beilan H.S., and Kunze K.L. N-Alkylprotoporphyrin IX formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the alkyl group from the substrate to the porphyrin. J Biol Chem 256 (1981) 6708-6713
8. Ortiz de Montellano P.R., Kunze K.L., Cole S.P., and Marks G.S. Differential inhibition of hepatic ferrochelatase by the isomers of N-ethylprotoporphyrin IX. Biochem Biophys Res Commun 103 (1981) 581-586
9. Lelli S.M., San Martin de Viale L.C., and Mazzetti M.B. Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species. Toxicology 216 (2005) 49-58
10. Monteiro H.P., Abdalla D.S.P., Augusto O., and Bechara E.J.H. Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathies. Arch Biochem Biophys 271 (1989) 206-216
11. Hanson R.W., and Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem 66 (1997) 581-611
12. Mazzetti M.B., Taira M.C., Lelli S.M., Dascal E., Basabe J.C., and San Martin de Viale L.C. Hexachlorobenzene impairs glucose metabolism in a rat model of porphyria cutanea tarda: a mechanistic approach. Arch Toxicol 78 (2004) 25-33
13. Weber L.W., Lebofsky M., Greim H., and Rozman K. Key enzymes of gluconeogenesis are dose-dependently reduced in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. Arch Toxicol 65 (1991) 119-123
14. Fan F., and Rozman K.K. Relationship between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and disturbance of intermediary metabolism in the Long-Evans rat. Arch Toxicol 69 (1994) 73-78
15. Stahl B.U., Beer D.G., Weber L.W., and Rozman K. Reduction of hepatic phosphoenolpyruvate carboxykinase (PEPCK) activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is due to decreased mRNA levels. Toxicology 79 (1993) 81-95
16. Veneziale C.M., Walter P., Kneer N., and Lardy H.A. Influence of l-tryptophan and its metabolites on gluconeogenesis in the isolated, perfused liver. Biochemistry 6 (1967) 2129-2138
17. Elliott K.R., Pogson C.I., and Smith S.A. Effects of tryptophan on gluconeogenesis in the rat and the guinea pig. Biochem Soc Trans 4 (1976) 1048-1049
18. Smith S.A., and Pogson C.I. Tryptophan and the control of plasma glucose concentrations in the rat. Biochem J 168 (1977) 495-506
19. Feigelson P., and Greengard O. A microsomal iron-porphyrin activator of rat liver tryptophan pyrrolase. J Biol Chem 236 (1961) 153-157
20. Badawy A.A., and Evans M. Regulation of rat liver tryptophan pyrrolase by its cofactor haem: experiments with hematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms. Biochem J 150 (1975) 511-520
21. Schimke R.T., Sweeney E.W., and Berlin C.M. The roles of synthesis and degradation in the control of rat liver tryptophan pyrrolase. J Biol Chem 240 (1965) 322-331
22. Knox W.E. Two mechanisms which increase in vivo the liver tryptophan peroxidase activity: specific enzyme adaptation and stimulation of the pituitary adrenal system. Br J Exp Pathol 32 (1951) 462-469
23. Knox W.E. The regulation of tryptophan pyrrolase activity by tryptophan. Adv Enzyme Regul 4 (1966) 287-297
24. Bissell D.M., and Hammaker L.E. Effect of endotoxin on tryptophan pyrrolase and delta-aminolevulinate synthase: evidence for an endogenous regulatory haem fraction in rat liver. Biochem J 166 (1977) 301-304
25. Badawy A.A. Tryptophan pyrrolase, the regulatory free haem and hepatic porphyrias. Early depletion of haem by clinical and experimental exacerbators of porphyria. Biochem J 172 (1978) 487-494
26. Correia M.A., and Burk R.F. Rapid stimulation of hepatic microsomal heme oxygenase in selenium-deficient rats. An effect of phenobarbital. J Biol Chem 253 (1978) 6203-6210
27. Weber L.W., Palmer C.D., and Rozman K. Reduced activity of tryptophan 2,3-dioxygenase in the liver of rats treated with chlorinated dibenzo-p-dioxins (CDDs): dose-responses and structure-activity relationship. Toxicology 86 (1994) 63-69
28. Morgan C.J., and Badawy A.A. Effects of acute carbamazepine administration on haem metabolism in rat liver. Biochem Pharmacol 43 (1992) 1473-1477
29. Tschudy D.P., Welland F.H., Collins A., and Hunter Jr. G. The effect of carbohydrate feeding on the induction of δ-aminolevulinic acid synthetase. Metabolism 13 (1964) 396-405
30. De Matteis F. Rapid loss of cytochrome P-450 and haem caused in the liver microsomes by the porphyrinogenic agent 2-allyl-2-isopropilacetamide. FEBS Lett 6 (1970) 343-345
31. De Matteis F., Abbritti G., and Gibbs A.H. Decreased liver activity of porphyrin metal chelatase in hepatic porphyria caused by 3,5-dietoxicarbonyl-1,4-dyhidrocollidine. Biochem J 134 (1973) 717-727
32. Marver H.S., Tscudy D.P., Perlroth M.J., and Collins A. Delta-aminolevulinic acid synthase. I. Studies in liver homogenates. J Biol Chem 241 (1966) 2803-2809
33. Petrescu I., Bojan O., Saied M., Barzu O., Schmidt F., and Kuhnle H.F. Determination of phosphoenolpyruvate-carboxykinase activity with deoxyguanosine 5′-diphosphate as nucleotide substrate. Anal Biochem 96 (1979) 279-281
34. Badawy A.A., and Evans M. Guinea-pig liver tryptophan pyrrolase. Absence of detectable apoenzyme activity and of hormonal induction by cortisol and possible regulation by tryptophan. Biochem J 138 (1974) 445-451
35. Piper W.N., Condie L.W., and Tephly T.R. The role of substrates for glycine acyltransferase in the reversal of chemically induced porphyria in the rat. Arch Biochem Biophys 159 (1973) 671-677
36. Mauzerall D., and Granick S. The occurence and determination of δ-aminoleculinic acid and porphobilinogen in urine. J Biol Chem 219 (1956) 435-446
37. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95 (1979) 351-358
38. Wolf W.A., and Kuhn D.M. Simultaneous determination of 5-hydroxytryptamine, its amino acid precursors and acid metabolite in discrete brain region by high-performance liquid chromatography with fluorescence detection. J Chromatogr 275 (1983) 1-9
39. Moran G.R., and Fitzpatrick P.F. A continuous fluorescence assay for tryptophan hydroxylase. Anal Biochem 266 (1999) 148-152
40. Lowry H.O., Rosebrough R.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
41. Badawy A.A., and Evans M. The effects of chemical porphyrogens and drugs on the activity of rat liner tryptophan pyrrolase. Biochem J 136 (1973) 885-892
42. Correia M.A., and Lunetta J.M. Acute hepatic heme depletion: impaired gluconeogenesis in rats. Semin Hematol 26 (1989) 120-127
43. Price J.M. Some effects of chelating agents on tryptophan metabolism in man. Fed Proc 20 (1961) 223-226
44. White A., Handler P., and Smith E.L. Amino acids metabolism-metabolic fates of amino acids. In: White A., Handler P., and Smith E.L. (Eds). Principles of biochemistry (1964), McGraw-Hill, New York 539-557
45. Rose J.A., Hellman E.S., and Tschudy D.P. Effect of diet on induction of experimental porphyria. Metabolism 10 (1961) 514-521