Greater impact of oral fluconazole on drug interaction with intravenous calcineurin inhibitors as compared with intravenous fluconazole

European Journal of Clinical Pharmacology

Volumn 64, Issue 1, 2008, Pages 89-91

  Mihara, Ai ^a   Mori, Takehiko ^a   Aisa, Yoshinobu ^a   Yamazaki, Rie ^a   Iketani, Osamu ^b   Tanigawara, Yusuke ^b   Ikeda, Yasuo ^a   Okamoto, Shinichiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Calcineurin inhibitors; Cyclosporine A; Drug interaction; Fluconazole; Tacrolimus

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN A; FLUCONAZOLE; TACROLIMUS;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG MONITORING; GRAFT VERSUS HOST REACTION; HUMAN; MAJOR CLINICAL STUDY; MYCOSIS; PRIORITY JOURNAL; RECIPIENT; STEADY STATE;

ANTIFUNGAL AGENTS; CALCINEURIN; CYCLOSPORINE; DRUG INTERACTIONS; FLUCONAZOLE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFUSIONS, INTRAVENOUS; RETROSPECTIVE STUDIES; TACROLIMUS;

EID: 38049051387     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-007-0395-0     Document Type: Article

References (12)

1. Goodman JL, Winston DJ, Greenfield RA, Chandrasekar PH, Fox B, Kaizer H et al (1992) A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med 326:845-851
2. Grant SM, Clissod SP (1990) Fluconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs 39:877-916
3. Canafax DM, Graves NM, Hilligoss DM, Carleton BC, Gardner MJ, Matas AJ (1991) Interaction between cyclosporine and fluconazole in renal allograft recipients. Transplantation 51:1014-1018
4. Campana C, Regazzi MB, Buggia I, Molinaro M (1995) Clinically significant drug interactions with cyclosporine. Clin Pharmacokinet 30:141-179
5. Christians U, Jacobsen W, Benet LZ, Lampen A (2002) Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet 41:813-851
6. Saad AH, DePestel DD, Carver PL (2006) Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants. Pharmacotherapy 26:1730-1744
7. Watkins PB (1997) The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv Drug Deliv Rev 27:161-170
8. Kaplan B, Lown K, Craig R, Abecassis M, Kaufman D, Leventhal J et al (1997) Low bioavailability of cyclosporine microemulsion and tacrolimus in a small bowel transplant recipient: possible relationship to intestinal P-glycoprotein activity. Transplantation 67:333-335
9. Masuda S, Uemoto S, Hashida T, Inomata Y, Tanaka K, Inui K (2000) Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient. Clin Pharmacol Ther 68:98-103
10. Ahonen J, Olkkola KT, Neuvonen PJ (1997) Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam. Eur J Clin Pharmacol 51:415-419
11. Palkama VJ, Isohanni MH, Neuvonen PJ, Olkkola KT (1998) The effect of intravenous and oral fluconazole on the pharmacokinetics and pharmacodynamics of intravenous alfentanil. Anesth Analg 87:190-194
12. Osowski CL, Dix SP, Lin LS et al (1996) Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant recipients. Transplantation 61:1268-1272