Correlation between patient weight and defects in DNA mismatch repair: Is this the link between an increased risk of previous cancer in thinner women with endometrial cancer?

International Journal of Gynecological Cancer

Volumn 18, Issue 1, 2008, Pages 136-140

  Cohn, D E ^a   Pavelka, J C ^a   Frankel, W L ^a   Morrison, C D ^a   Hampel, H ^a   Copeland, L J ^a   Fowler, J M ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Endometrial cancer; Mismatch repair; Obesity

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; BODY WEIGHT; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOMETRIUM CANCER; FEMALE; GENE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MLH1 GENE; MSH2 GENE; MSH6 GENE; OBESITY; PMS2 GENE; PRIORITY JOURNAL; TISSUE MICROARRAY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATASES; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; BODY WEIGHT; BREAST NEOPLASMS; DNA MISMATCH REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; ENDOMETRIAL NEOPLASMS; FEMALE; GENOTYPE; HUMANS; IMMUNOENZYME TECHNIQUES; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; THINNESS; TISSUE ARRAY ANALYSIS;

EID: 38049041551     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2007.00964.x     Document Type: Article

References (13)

1. Jemal A, Siegel R, Ward E et al. Cancer statistics, 2006. CA Cancer J Clin 2006 56 : 106 30.
2. Aarnio M, Sankila R, Pukkala E et al. Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 1999 81 : 214 8.
3. Risinger JI, Berchuck A, Kohler MF, Watson P, Lynch HT, Boyd J. Genetic instability of microsatellites in endometrial carcinoma. Cancer Res 1993 53 : 5100 3.
4. Esteller M, Levine R, Baylin SB, Ellenson LH, Herman JG. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 1998 17 : 2413 7.
5. Pavelka JC, Ben-Shachar I, Fowler JM et al. Morbid obesity and endometrial cancer: surgical, clinical, and pathologic outcomes in surgically managed patients. Gynecol Oncol 2004 95 : 588 92.
6. Kuriyama S, Tsubono Y, Hozawa A et al. Obesity and risk of cancer in Japan. Int J Cancer 2005 113 : 148 57.
7. Pan SY, Johnson KC, Ugnat AM, Wen SW, Mao Y. Association of obesity and cancer risk in Canada. Am J Epidemiol 2004 159 : 259 68.
8. Simon R, Mirlacher M, Sauter G. Tissue microarrays in cancer diagnosis. Expert Rev Mol Diagn 2003 3 : 421 30.
9. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983 15 : 10 7.
10. Anderson B, Connor JP, Andrews JI et al. Obesity and prognosis in endometrial cancer. Am J Obstet Gynecol 1996 174 : 1171 8 discussion 1178 9.
11. Sherman ME, Bur ME, Kurman RJ. p53 in endometrial cancer and its putative precursors: evidence for diverse pathways of tumorigenesis. Hum Pathol 1995 26 : 1268 74.
12. Risinger JI, Maxwell GL, Berchuck A, Barrett JC. Promoter hypermethylation as an epigenetic component in Type I and Type II endometrial cancers. Ann N Y Acad Sci 2003 983 : 208 12.
13. McCourt CK, Mutch DG, Gibb RK et al. Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer. Gynecol Oncol 2007 104 : 535 9.