Synthesis and pharmacological activity of aminoindanone dimers and related compounds

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 248-254

  Sheridan, H ^a   Butterly, S ^a   Walsh, J J ^a   Cogan, C ^a   Jordan, M ^a   Nolan, O ^a   Frankish, N ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

3 Aminoindanones; Bi indanyl amines; Indanones; Mediator release inhibition; Smooth muscle relaxant activity

Indexed keywords

3 (CYCLOPENTYLAMINO)INDAN 1 ONE; 3 (N CYCLOPENTYL N METHYLAMINO)INDAN 1 ONE; AMINE; COMPOUND 48-80; CROMOGLYCATE DISODIUM; DIMER; HISTAMINE; INDANONE DERIVATIVE; NIFEDIPINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; GUINEA PIG; HISTAMINE RELEASE; MEDIATOR RELEASE; NONHUMAN; RAT; SMOOTH MUSCLE RELAXATION; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; FEMALE; GUINEA PIGS; HISTAMINE; ILEUM; INDANS; MAST CELLS; MUSCLE RELAXATION; MUSCLE, SMOOTH; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38049030636     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.09.041     Document Type: Article

References (16)

1. Vaccva J., Dorsey B., Schleif W., Levin R., McDaniel S., Darke P., Zugay J., Quinterno J., Blahy O., and Roth E. Proc. Natl Acad. Sci. U.S.A. 91 (1994) 4096-4100
2. Buckle D., Morgan N., Ross J., Smith H., and Spicer B. J. Med. Chem. 16 (1973) 1334-1339
3. Heinzelmann R., Kolloff H., and Hunter J. J. Org. Chem. 14 (1940) 907-910
4. Sheridan H., Lemon S., Frankish N., McCardle P., Higgins T., James J., and Bhandari P. Eur. J. Med. Chem. 25 (1990) 603-608
5. Sheridan H., Frankish N., and Farrell R. Eur. J. Med. Chem. 34 (1999) 953-966
6. Sheridan H., Frankish N., and Farrell R. Planta Med. 65 (1999) 271-272
7. Frankish N., Farrell R., and Sheridan H. J. Pharm. Pharmacol. 56 (2004) 1423-1427
8. Walsh, J.; Frankish, N.; Sheridan, H.; Byrne, W. US Patent 6,423,752, 2002.
9. Ho S., Yang M., Wu T., and Wang C. Planta Med. 51 (1985) 148-150
10. Yang M. Planta Med. 52 (1996) 25-27
11. Theoharides T., and Kalogeromitros D. Ann. N. Y. Acad. Sci. 1088 (2006) 78-99
12. Stassen M., Hultner L., Muller C., and Schmitt E. Arch. Immunol. Ther. Exp. 50 (2002) 179-185
13. Tanizaki Y., Ohtani J., and Kimura I. Agents Actions 37 (1992) 8-15
14. Loeffler L., Lovenberg W., and Sjoerdsma A. Biochem. Pharmacol. 20 (1971) 2287-2297
15. Amellel M., Binck M., Frossard N., Ilien B., and Landry Y. Br. J. Pharmacol. 82 (1984) 423-430
16. Shore P., Burkhalter A., and Cohn V. J. Pharmacol. Exp. Ther. 127 (1959) 182