A phase II trial of transcatheter arterial infusion chemotherapy with an epirubicin-Lipiodol emulsion for advanced hepatocellular carcinoma refractory to transcatheter arterial embolization

Cancer Chemotherapy and Pharmacology

Volumn 61, Issue 4, 2008, Pages 683-688

  Tanaka, Tsutomu ^a   Ikeda, Masafumi ^a   Okusaka, Takuji ^a   Ueno, Hideki ^a   Morizane, Chigusa ^a   Ogura, Takashi ^a   Hagihara, Atsushi ^a   Iwasa, Satoru ^a  

^a NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

Epirubicin; Hepatocellular carcinoma; Transcatheter arterial embolization; Transcatheter arterial infusion chemotherapy

Indexed keywords

EPIRUBICIN; IODINATED POPPYSEED OIL;

ADULT; ADVANCED CANCER; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHEMOEMBOLIZATION; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EMULSION; FEMALE; HUMAN; LEUKOPENIA; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SIDE EFFECT; SURVIVAL TIME; THROMBOCYTOPENIA; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-FETOPROTEINS; ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA, HEPATOCELLULAR; CATHETERIZATION, PERIPHERAL; DISEASE-FREE SURVIVAL; EMBOLIZATION, THERAPEUTIC; EMULSIONS; EPIRUBICIN; FEMALE; HUMANS; INFUSIONS, INTRA-ARTERIAL; IODIZED OIL; LIVER NEOPLASMS; MALE; MIDDLE AGED;

EID: 38049001948     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0523-7     Document Type: Article

References (23)

1. Cottone M, Turri M, Caltagirone M et al (1988) Early detection of hepatocellular carcinoma associated with cirrhosis by ultrasound and alpha-fetoprotein: a prospective study. Hepatogastroenterology 35:101
2. Ensminger WD, Gyves JW (1983) Clinical pharmacology of hepatic arterial chemotherapy. Semin Oncol 10:176-182
3. Geschwind JF, Salem R, Carr BI, Soulen MC, Thurston KG, Goin KA et al (2004) Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Gastroenterology 127:S194-S205
4. Hochster HS, Green MD, Speyer J, Fazzini E, Blum R, Muggia FM (1985) 4'-epidoxorubicin (Epirubicin): activity in hepatocellular carcinoma. J Clin Oncol 3:1535-1540
5. Japan Society for Cancer (1993) Therapy criteria for the evaluation of the clinical effects of solid cancer chemotherapy. J Jpn Soc Cancer Ther 28:101-130
6. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 63:457-481
7. Lai CL, Wu PC, Chan GC, Lok AS, Lin HJ (1988) Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial. Cancer 62:479-483
8. Llovet JM, Bruix J (2003) Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 37:429-442
9. Llovet JM, Real MI, Montana X, Planas R, Coll S, Aponte J et al (2002) Arterial embolization or chemoembolization versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomized controlled trial. Lancet 359:1734-1739
10. Lo CM, Ngan H, Tsu WK, Liu CL, Lam CM, Poon RT et al (2002) Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 35:1164
11. Matsui O, Kadoya M, Yoshikawa J, Gabata T, Takashima T, Demachi H et al (1993) Small hepatocellular carcinoma: treatment with subsegmental transcatheter arterial embolization. Radiology 188:79-83
12. Minoyama A, Yoshikawa M, Ebara M, Saisho H, Sugiura N, Ohto M (1995) Study of repeated arterial infusion chemotherapy with a subcutaneously implanted reservoir for advanced hepatocellular carcinoma. J Gastroenterol 30:356-366
13. Nagasue N, Yukaya H, Okamura J, Kuroda C, Kubo Y, Hirai K et al (1987) Intraarterial administration of epirubicin in the treatment of non-resectable hepatocellular carcinoma. Cancer Chemother Pharmacol 19:183-189
14. Ohishi Y, Uchida H, Yoshimura H, Ohue S, Ueda J, Katsuragi M et al (1985) Hepatocellular carcinoma detected by iodized oil: use of anticancer agents. Radiology 154:25-29
15. Okuda K (1992) Hepatocellular carcinoma: recent progress. Hepatology 15:948-963
16. Okuda K, Tanaka M, Shibata J, Ando E, Ogata T, Kinoshita H et al (1999) Hepatic arterial infusion chemotherapy with continuous low dose administration of cisplatin and 5-fluorouracil for multiple recurrence of hepatocellular carcinoma after surgical treatment. Oncol Rep 6:587-591
17. Okuda S (1998) Transcatheter arterial embolization for advanced hepatocellular carcinoma: The controversy continues. Hepatology 27:1743-1744
18. Ramming KP (1983) The effectiveness of hepatic artery infusion in treatment of primary hepatobiliary tumors. Semin Oncol 10:199-205
19. Sala M, Llovet JM, Vilana R et al (2004) Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma. Hepatology 40:1352-1360
20. Sangro B, Rios R, Bilbao I, Beloqui O, Herrero JI, Quiroqa J et al (2002) Efficacy and toxicity of intra-arterial cisplatin and etoposide for advanced hepatocellular carcinoma. Oncology 62:293-298
21. Sumie S, Yamashida F, Ando E, Tanaka M, Yano Y, Fukumori K, Sata M (2003) Interventional radiology for advanced hepatocellular carcinoma: comparison of hepatic artery infusion chemotherapy and chemoembolization. Am J Roentgenol 181:1327-1334
22. Yoshikawa M, Saisho H, Ebara M, Iijima T, Iwama S, Endo F et al (1994) A randomized trial of intrahepatic arterial infusion of 4'-epidoxorubicin with lipiodol versus 4'-epidoxorubicin alone in the treatment of hepatocellular carcinoma. Cancer Chemother Pharmacol 33:S149-S152
23. Yumoto Y, Jinno K, Tokuyama K, Araki Y, Ishimitsu T, Maeda H et al (1985) Hepatocellular carcinoma detected by iodized oil. Radiology 154:19-24