Cardiopulmonary effects of dexmedetomidine in goats and sheep anaesthetised with sevoflurane

Veterinary Record

Volumn 159, Issue 19, 2006, Pages 624-629

  Kutter, A P N ^a   Kastner S B R ^a   Bettschart Wolfensberger, R ^a   Huhtinen, M ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ORION CORPORATION   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CARPROFEN; DEXMEDETOMIDINE; SEVOFLURANE;

ANESTHESIA; ANIMAL EXPERIMENT; ARTERIAL OXYGEN TENSION; ARTERIAL PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; CARDIOPULMONARY BYPASS; CARDIOPULMONARY FUNCTION; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG TISSUE LEVEL; FEMALE; GOAT; HEART OUTPUT; HEART RATE; LUNG ALVEOLUS; LUNG ARTERY PRESSURE; LUNG CAPILLARY PRESSURE; LUNG COMPLIANCE; LUNG DEAD SPACE; LUNG FUNCTION; LUNG RESISTANCE; LUNG WEDGE PRESSURE; MALE; NONHUMAN; POSITION; SHEEP; SPECIES DIFFERENCE;

ANIMALIA; CAPRA HIRCUS; OVIS ARIES;

EID: 37849188371     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.159.19.624     Document Type: Article

References (46)

1. AHMED, T., OLIVER, W. & WANNER, A. (1983) Variability of hypoxic pulmonary vasoconstriction in sheep. American Review of Respiratory Diseases 127, 59-62
2. AZIZ, M. A. & CARLYLE, S. S. (1978) Cardiovascular and respiratory effects of xylazine in sheep. Zentralblatt für Veterinärmedizin A 25, 173-180
3. BACON, P. J., JONES, J. G., TAYLOR, P., STEWART, S., WILSON-NUNN, D. & KERR, M. (1998) Impairment of gas exchange due to alveolar oedema during xylazine sedation in sheep; absence of a free radical-mediated inflammatory mechanism. Research in Veterinary Science 65, 71-75
4. BOLLER, J., KÄSTNER, S. B. R., KUTTER, A. P. N., BETTSCHART-WOLFENSBERGER, R. & HUHTINEN, M. (2004) The effect of dexmedetomidine constant rate infusion on cardiopulmonary parameters in sheep during sevoflurane anaesthesia. Proceedings of the Association of Veterinary Anaesthetists Autumn Meeting. Vienna, Austria, September 15 to 17, 2004. p 80
5. CAULKETT, N. A., DUKE, T. & CRIBB, P. H. (1996) Cardiopulmonary effects of medetomidine-ketamine in domestic sheep (Ovis ovis) maintained in sternal recumbency. Journal of Zoo and Wildlife Medicine 27, 217-226
6. 2-adrenergic receptor agonists. American Journal of Veterinary Research 60, 154-161
7. 2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. Journal of Pharmacology and Experimental Therapy 289, 712-720
8. 2-adrenoceptor agonist ST-91 in conscious sheep. Journal of Veterinary Pharmacology and Therapeutics 20, 472-478
9. 2-adrenoceptor agonists (xylazine, romifidine, detomidine and medetomidine) in sheep. Journal of Veterinary Pharmacology and Therapeutics 20, 464-471
10. CLARKE, K. W. (1999) Desflurane and sevoflurane; new volatile anaesthetic agents. Veterinary Clinics of North America: Small Animal Practice 29, 793-809
11. CLARKE, K. W. & HALL, L. W. (1969) Xylazine - a new sedative for horses and cattle. Veterinary Record 85, 512-517
12. DOCHERTY, J. R. & MCGRATH, J. C. (1980) A comparison of pre- and postjunctional potencies of several α-adrenoceptor agonists in the cardiovascular system and anococcygeus muscle of the rat. Naunyn-Schmiedeberg's Archives of Pharmacology 312, 107-116
13. DYCK, J. B., MAZE, M., HAAK, C. & VUORILEHTO, L. (1993) The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology 78, 813-820
14. 2-adrenergic mechanism. Journal of Pharmacology and Experimental Therapy 244, 247-252
15. 2-adrenergic agonist, MPV-2426, in sheep. Anesthesiology 91, 1425-1436
16. HEDENSTIERNA, G., LUNDQUIST, H., LUNDH, B., TOKICS, L., STRANDBERG, A., BRISMAR, B. & FROSTELL, C. (1989) Pulmonary densities during anesthesia. An experimental study on lung morphology and gas exchange. European Respiration Journal 2, 528-535
17. ISHIBE, Y, GUI, X., UNO, H., SHIOKAWA, Y., UMEDA, T. & SUEKANE, K. (1993) Effect of sevoflurane on hypoxic pulmonary vasoconstriction in the perfused rabbit lung. Anesthesiology 79, 1348-1353
18. KÄSTNER, S. B. R., KUTTER, A. P. N., VON RECHENBERG, B. & BETTSCHART-WOLFENSBERGER, R. (2006) Comparison of two pre-anaesthetic medetomidine doses in isoflurane anaesthetized sheep. Veterinary Anaesthesia and Analgesia 33, 8-16
19. KÄSTNER, S. B. R., VON RECHENBERG, B., KELLER, K. & BETTSCHART-WOLFENSBERGER, R. (2001) Comparison of medetomidine and dexme-detomidine as premedication in isoflurane anaesthesia for orthopaedic surgery in domestic sheep. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine 48, 231-241
20. KÄSTNER, S. B. R., WAPF, P., FEIGE, K., DEMUTH, D., BETTSCHART-WOLFENSBERGER, R., AKENS, M. K. & HUHTINEN, M. (2003) Pharmacokinetics and sedative effects of intramuscular medetomidine in domestic sheep. Journal of Veterinary Pharmacology and Therapeutics 26, 271-276
21. KUMAR, A. & THURMON, J. C. (1979) Cardiopulmonary, hemocytologic and biochemical effects of xylazine in goats. Laboratory Animal Science 29, 486-491
22. LAWRENCE, C. J., PRINZEN, F. W. & DE LANGE, S. (1997) Hemodynamic and coronary vascular effects of dexmedetomidine in the anesthetized goat. Acta Anaesthesiologica Scandinavica 41, 830-836
23. LUKASIK, V. M., NOGAMI, W. M. & MORGAN, S. E. (1998) Minimum alveolar concentration and cardiovascular effects of sevoflurane in sheep. Veterinary Surgery 27, 168
24. MARSHALL, C., LINDGREN, L. & MARSHALL, B. E. (1984) Effects of halothane, enflurane, and isoflurane on hypoxic pulmonary vasoconstriction in rat lungs in vitro. Anesthesiology 60, 304-308
25. 2-adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 74, 581-605
26. MITCHELL, B. & WILLIAMS, J. B. (1977) Respiratory function changes in sheep associated with lying in lateral recumbency and with sedation by xylazine. Proceedings of the Association of Veterinary Anaesthetists 6, 30-36
27. MOGOA, E. G., STEGMANN, G. R & GUTHRIE, A. J. (2000) Effects of xylazine on acid-base balance and arterial blood-gas tensions in goats under different environmental temperature and humidity conditions. Journal of the South African Veterinary Association 71, 229-231
28. MUGE, D. K., CHAMBERS, J. P., LIVINGSTON, A. & WATERMAN, A. E. (1994) Analgesic effects of medetomidine in sheep. Veterinary Record 135, 43-44
29. 2-adrenoceptor agonists on airway pressure in anaesthetized sheep. Journal of Veterinary Pharmacology and Therapeutics 9, 157-163
30. O'HALLORAN, K. D., HERMAN, J. K. & BISGARD, G. E. (2000) Clonidine induces upper airway closure in awake goats. Respiration Physiology 123, 165-176
31. 2A-adrenoceptor mediated tachypnea in awake goats. Respiration Physiology 125, 169-179
32. PAPAZOGLOU, L., RAPTOPOULOS, D. & KOKOLIS, N. (1994) Increased airway pressure in response to xylazine is inhibited by both atipamezole and atropine in sheep. Zentralblatt für Veterinärmedizin A 41, 568-572
33. PAPAZOGLOU, L., RAPTOPOULOS, D. & KOUNENIS, G. (1995) The effect of xylazine on the isolated sheep trachea Journal of Veterinary Pharmacology and Therapeutics 18, 216-219
34. RAPTOPOULOS, D., KOUTINAS, A., MOUSTARDAS, N. & PAPASTERIADIS, A. (1985) The effect of xylazine or xylazine plus atropine on blood gases in sheep. Proceedings of the 2nd International Congress of Veterinary Anaesthesia. Sacramento, USA, October 7 to 10, 1985. pp 201-202
35. RAPTOPOULOS, D., WEAVER, B. M. Q., PAPANASTASSOPOULOS, M., STADDEN, G. E. & PARKINSON, T. J. (1995) The effect of xylazine on plasma thromboxane B2 concentration in sheep. Journal of Veterinary Pharmacology and Therapeutics 18, 438-441
36. ROBINSON, N. E. (1982) Some functional consequences of species-differences in lung anatomy. Advances in Veterinary Science and Comparative Medicine 26, 1-33
37. SAKAMOTO, H., KIRIHARA, H., FUJIKI, M., MIURA, N. & MISUMI, K. (1997) The effects of medetomidine on maternal and fetal cardiovascular and pulmonary function, intrauterine pressure and uterine blood flow in pregnant goats. Experimental Animals 46, 67-73
38. SAKAMOTO, H., MISUMI, K., NAKAMA, M. & AOKI, Y. (1996) The effects of xylazine on intrauterine pressure, uterine blood flow, maternal and fetal cardiovascular and pulmonary function in pregnant goats. Journal of Veterinary Medical Science 58, 211-217
39. 2-adrenoreceptors. Journal of Autonomic Pharmacology 6, 275-284
40. 2-antagonist on organ blood flow in sheep. Anesthesia and Analgesia 90, 1060-1066
41. TAYLOR, P. M. (1991) Anaesthesia in sheep and goats. In Practice 13, 31-36
42. UGGLA, A. & LINDQUIST, A. (1983) Acute pulmonary oedema as an adverse reaction to the use of xylazine in sheep. Veterinary Record 113, 42
43. 2-agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Research 319, 69-101
44. VICKERY, R. G. & MAZE, M. (1989) Action of the stereoisomers of medetomidine, in halothane-anesthetized dogs. Acta Veterinaria Scandinavica 85, 71-76
45. 2-adrenergic agonist in halothane anesthetized dogs. Anesthesia and Analgesia 67, 611-615
46. 2-adrenoceptor agonist. European Journal of Pharmacology 150, 9-14