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Guarantor of the article: Nicholas J. Talley, M.D., Ph.D. Specific author contributions: Study design, review of data, manuscript revision - Nicholas J. Talley, G. Richard Locke, III, M. McNally, Alan R. Zinsmeister, and L. Joseph Melton, III. Manuscript preparation - Nicholas J. Talley. Statistical analysis - Alan R. Zinsmeister and Cathy D. Schleck. Financial support: None. Potential competing interests: Nicholas J. Talley: grant/research support: Tap Pharmaceuticals, GlaxoSmithKline. G. Richard Lock, III: grant/research support: AstraZeneca, GlaxoSmithKline, Janssen, TAP; consulting: Boehringer Ingelheim, GlaxoSmithKline, Novartis, Solvay, Takeda. Meredythe McNally: none to declare. Cathy D. Schleck: none to declare. Alan R. Zinsmeister: none to declare. L. Joseph Melton, III: none to declare.
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