Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+

Proteins: Structure, Function and Genetics

Volumn 70, Issue 2, 2008, Pages 517-527

  Nango, Eriko ^a   Kumasaka, Takashi ^a   Hirayama, Toshifumi ^a   Tanaka, Nobuo ^a   Eguchi, Tadashi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Aminoglycoside antibiotics; Biosynthesis; Deoxystreptamine; Mechanism based inhibitor; Reaction mechanism

Indexed keywords

2 DEOXY SCYLLO INOSOSE SYNTHASE; 2 DEOXYSTREPTAMINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; COBALT; DIMER; ENZYME; GLUCOSE 6 PHOSPHATE; GLUTAMIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR MODEL; PRIORITY JOURNAL; REACTION ANALYSIS;

ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; HEXOSAMINES; LYASES; MODELS, MOLECULAR; NAD; PROTEIN CONFORMATION;

BACILLUS CIRCULANS;

EID: 37849043342     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21526     Document Type: Article

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