Use of p63 and CD10 in the differential diagnosis of papillary neoplasms of the breast

Breast Journal

Volumn 14, Issue 1, 2008, Pages 68-75

  De Moraes Schenka, Natália Guimarães ^a   Schenka, André Almeida ^a   De Souza Queiroz, Luciano ^a   De Almeida Matsura, Marisa ^a   Vassallo, José ^a   Alvarenga, Marcelo ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Breast; CD10; Myoepithelial cells; p63; Papillary neoplasms

Indexed keywords

CALPONIN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; PROTEIN P63; TUMOR MARKER;

ARTICLE; BENIGN TUMOR; BREAST CARCINOMA; BREAST PAPILLOMA; BREAST TUMOR; CELL STRUCTURE; CONTROLLED STUDY; CROSS REACTION; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; MALIGNANT NEOPLASTIC DISEASE; MYOEPITHELIUM CELL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STAINING; TUMOR DIFFERENTIATION;

BREAST NEOPLASMS; CALCIUM-BINDING PROTEINS; CARCINOMA, PAPILLARY; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; NEPRILYSIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 37849038636     PISSN: 1075122X     EISSN: 15244741     Source Type: Journal    
DOI: 10.1111/j.1524-4741.2007.00518.x     Document Type: Article

References (29)

1. Tavassoli FA, Devilee P, World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Breast and Female Genital Organs. Lyon : IARC Press, 2003.
2. Tavassoli FA. Pathology of the Breast, 2nd edn. New York : McGraw-Hill, 1999.
3. Azzopardi JG. Papilloma and papillary carcinoma. In : Azzopardi JG, ed. Problems in Breast Pathology. Philadelphia : WB Saunders, 1979 : 150 66.
4. Putti TC, Pinder SE, Elston CW, Lee AHS, Ellis IO. Breast pathology practice: most common problems in a consultation service. Histopathology 2005 47 : 445 57.
5. Maluf HM, Koerner FC. Solid papillary carcinoma of the breast. Am J Surg Pathol 1995 19 : 1237 44.
6. Papotti M, Eusebi V, Gugliotta P, Bussolati G. Immunohistochemical analysis of benign and malignant papillary lesions of the breast. Am J Surg Pathol 1983 7 : 451 61.
7. Carder PJ, Garvican J, Haigh I, Liston JC. Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast. Histopathology 2005 46 : 320 7.
8. Ivan D, Selinko V, Sahin AA, Sneige N, Middleton LP. Accuracy of core needle biopsy in assessing papillary breast lesions: histologic predictors for malignancy. Mod Pathol 2004 17 : 165 71.
9. Egan MJ, Newman J, Crocker J, Collard M. Immunohistochemical localization of S-100 protein in benign and malignant conditions of the breast. Arch Pathol Lab Med 1987 111 : 28 31.
10. Raju UB, Lee MW, Zarbo RJ, Crissman JD. Papillary neoplasia of the breast: immunohistochemically defined myoepithelial cells in the diagnosis of benign and malignant papillary breast neoplasms. Mod Pathol 1989 2 : 569 76.
11. Mosunjac MB, Lewis MM, Lawson D, Cohen C. Use of a novel marker, calponin, for myoepithelial cells in fine-needle aspirates of papillary breast lesions. Diagn Cytopathol 2000 23 : 151 5.
12. NTR) as a marker of breast myoepithelial cells. Mod Pathol 2005 18 : 1535 41.
13. Gugliotta P, Sapino A, Macri L, et al. Specific demonstration of myoepithelial cells by anti-alpha smooth muscle actin antibody. J Histochem Cytochem 1988 36 : 659 63.
14. Moritani S, Kushima R, Sugihara H, et al. Availability of CD10 immunohistochemistry as a marker of breast myoepithelial cells on paraffin sections. Mod Pathol 2002 15 : 397 405.
15. Barbareschi M, Pecciarini L, Cangi MG, et al. p63, a p53 homologue is a selective nuclear marker of myoepithelial cells of the human breast. Am J Surg Pathol 2001 25 : 1054 60.
16. de Moraes Schenka NG, Schenka AA, de Souza Queiroz L, et al. p63 and CD10: reliable markers in discriminating benign sclerosing lesions from tubular carcinoma of breast? Appl Immunohistochem Mol Morphol 2006 14 : 71 7.
17. Werling RW, Hwang H, Yaziji H, Gown AM. Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain. Am J Surg Pathol 2003 27 : 82 90.
18. Mills AA, Zheng B, Wang XJ, et al. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999 398 : 708 13.
19. Di Como CJ, Urist MJ, Babayan I, et al. p63 expression profiles in human normal and tumor tissues. Clin Cancer Res 2002 8 : 494 501.
20. Zhang RR, Man YG, Vang R, et al. A subset of morphologically distinct mammary myoepithelial cells lacks corresponding immunophenotypic markers. Breast Cancer Res 2003 5 : R151 6.
21. Popnikolov NK, Ayala AG, Graves K, Gatalica Z. Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrix-producing and spindle cell carcinomas. Am J Clin Pathol 2003 120 : 161 7.
22. Reis-Filho JS, Simpson PT, Martins A, et al. Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch 2003 443 : 122 32.
23. Ribeiro-Silva A, Zamzelli Ramalho LN, Garcia SB, Zucoloto S. Is p63 reliable in detecting microinvasion in ductal carcinoma in situ of the breast? Pathol Oncol Res 2003 9 : 20 3.
24. Kalof AN, Tam D, Beatty B, Cooper K. Immunostaining patterns of myoepithelial cells in breast lesions: a comparison of CD10 and smooth muscle myosin heavy chain. J Clin Pathol 2004 57 : 625 9.
25. Troxell ML, Masek M, Sibley RK Immunohistochemical markers in papillary lesions of the breast. Modern Pathol 2002 15 : 54A [Abstract 213].
26. Hill CB, Yeh IT. Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas. Am J Clin Pathol 2005 123 : 36 44.
27. Puglisi F, Zuiani C, Bazzocchi M, et al. Role of mammography, ultrasound and large core biopsy in the diagnostic evaluation of papillary breast lesions. Oncology 2003 65 : 311 5.
28. Jacobs TW, Connolly JL, Schnitt SJ. Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? Am J Surg Pathol 2002 26 : 1095 110.
29. Agoff SA, Lawson TJ. Papillary lesions of the breast with and without atypical ductal hyperplasia: can we accurately predict benign behavior from core needle biopsy? Am J Clin Pathol 2004 122 : 440 3.