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Volumn 7, Issue 4, 2007, Pages 214-222

Lubiprostone: A new drug for the treatment of chronic idiopathic constipation

Author keywords

Constipation; Irritable bowel syndrome; Lubiprostone

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ANTACID AGENT; ANTIDIARRHEAL AGENT; ANTIPARKINSON AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; DIURETIC AGENT; IRON; LAXATIVE; LUBIPROSTONE; MACROGOL; MISOPROSTOL; MORPHINE; MOXIFLOXACIN; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PLACEBO; PROSTAGLANDIN E1; TEGASEROD; TRICYCLIC ANTIDEPRESSANT AGENT;

EID: 37849038254     PISSN: 1533001X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (2)

References (39)
  • 1
    • 0034465039 scopus 로고    scopus 로고
    • AGA technical review on constipation
    • American Gastroenterological Association
    • American Gastroenterological Association. AGA technical review on constipation. Gastroenterology. 2000;119:1766-1778.
    • (2000) Gastroenterology , vol.119 , pp. 1766-1778
  • 2
    • 0034464011 scopus 로고    scopus 로고
    • American Gastroenterological Association medical position statement: Guidelines on constipation
    • American Gastroenterological Association
    • American Gastroenterological Association. American Gastroenterological Association medical position statement: guidelines on constipation. Gastroenterology. 2000;119:1761-1766.
    • (2000) Gastroenterology , vol.119 , pp. 1761-1766
  • 3
    • 28744437214 scopus 로고    scopus 로고
    • Treatment of constipation in older adults
    • Hsieh C. Treatment of constipation in older adults. Am Fam Physician. 2005;72:2277-2284.
    • (2005) Am Fam Physician , vol.72 , pp. 2277-2284
    • Hsieh, C.1
  • 4
    • 33748799429 scopus 로고    scopus 로고
    • Treating chronic constipation: How should we interpret the recommendations?
    • Johnson DA. Treating chronic constipation: how should we interpret the recommendations? Clin Drug Invest. 2006;26:547-557.
    • (2006) Clin Drug Invest , vol.26 , pp. 547-557
    • Johnson, D.A.1
  • 5
    • 37849016508 scopus 로고    scopus 로고
    • Hanover, NJ: Novartis Pharmaceuticals; July, Available at:, Accessed September 11, 2007
    • Novartis Pharmaceuticals. Zelnorm (tegaserod maleate). East Hanover, NJ: Novartis Pharmaceuticals; July 2007. Available at: www.zelnorm.com. Accessed September 11, 2007.
    • (2007) Novartis Pharmaceuticals. Zelnorm (tegaserod maleate). East
  • 6
    • 37849048155 scopus 로고    scopus 로고
    • Sucampo Pharmaceuticals. Amitiza (lubiprostone) soft gelatin capsules [package insert, Bethesda, MD: Sucampo Pharmaceuticals; February 2006
    • Sucampo Pharmaceuticals. Amitiza (lubiprostone) soft gelatin capsules [package insert]. Bethesda, MD: Sucampo Pharmaceuticals; February 2006.
  • 7
    • 6044278151 scopus 로고    scopus 로고
    • SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents
    • Cuppoletti J, Malinowska DH, Tewari KP, et al. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol. 2004;287:C1173-C1183.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Cuppoletti, J.1    Malinowska, D.H.2    Tewari, K.P.3
  • 8
    • 33645837674 scopus 로고    scopus 로고
    • Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers
    • Camilleri M, Bharucha AE, Ueno R, et al. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol. 2006;290:G942-G947.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Camilleri, M.1    Bharucha, A.E.2    Ueno, R.3
  • 9
    • 37849011793 scopus 로고    scopus 로고
    • Effects of lubiprostone, a novel GI chloride channel activator, on isolated smooth muscle [abstract 900]
    • Perentesis GP, Crawford DF, Engelke KJ, et al. Effects of lubiprostone, a novel GI chloride channel activator, on isolated smooth muscle [abstract 900]. Am J Gastroenterol. 2005;100(9 suppl):S330.
    • (2005) Am J Gastroenterol , vol.100 , Issue.9 SUPPL.
    • Perentesis, G.P.1    Crawford, D.F.2    Engelke, K.J.3
  • 10
    • 34147183836 scopus 로고    scopus 로고
    • Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the Clc-2 chloride channel, Spi-0211 [abstract]
    • Moeser A, Engelke K, Perentesis GP, et al. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the Clc-2 chloride channel, Spi-0211 [abstract]. Gastroenterology. 2005;128(4 suppl 2):A539.
    • (2005) Gastroenterology , vol.128 , Issue.4 SUPPL. 2
    • Moeser, A.1    Engelke, K.2    Perentesis, G.P.3
  • 12
    • 37849044070 scopus 로고    scopus 로고
    • Lubiprostone activates single chloride channels in the apical membrane of A6 epithelial cells [abstract T1875]
    • Presented at, May 19-24, Washington, DC
    • Eaton DC, Bao H, Liu L, Ueno R. Lubiprostone activates single chloride channels in the apical membrane of A6 epithelial cells [abstract T1875]. Presented at Digestive Disease Week 2007; May 19-24, 2007; Washington, DC.
    • (2007) Digestive Disease Week 2007
    • Eaton, D.C.1    Bao, H.2    Liu, L.3    Ueno, R.4
  • 13
    • 37849042996 scopus 로고    scopus 로고
    • Stimulation of mucosal secretion by lubiprostone in guinea-pig small intestine and colon [abstract W1206]
    • Presented at, May 19-24, Washington, DC
    • Fei G, Liu S, Wang G, et al. Stimulation of mucosal secretion by lubiprostone in guinea-pig small intestine and colon [abstract W1206]. Presented at Digestive Disease Week 2007; May 19-24, 2007; Washington, DC.
    • (2007) Digestive Disease Week 2007
    • Fei, G.1    Liu, S.2    Wang, G.3
  • 14
    • 34147173976 scopus 로고    scopus 로고
    • Lubiprostone: A chloride channel activator
    • Lacy BE, Levy LC. Lubiprostone: a chloride channel activator. J Clin Gastroenterol. 2007;41:345-351.
    • (2007) J Clin Gastroenterol , vol.41 , pp. 345-351
    • Lacy, B.E.1    Levy, L.C.2
  • 15
    • 15544388091 scopus 로고    scopus 로고
    • Structure and function of CLC channels
    • Chen TY. Structure and function of CLC channels. Annu Rev Physiol. 2005;67:809-839.
    • (2005) Annu Rev Physiol , vol.67 , pp. 809-839
    • Chen, T.Y.1
  • 16
    • 33847009038 scopus 로고    scopus 로고
    • Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the CIC-2 chloride channel, lubiprostone
    • Moeser AJ, Nighot PK, Engelke KJ, et al. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the CIC-2 chloride channel, lubiprostone. Am J Physiol Gastrointest Liver Physiol. 2007;292:G647-G656.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Moeser, A.J.1    Nighot, P.K.2    Engelke, K.J.3
  • 17
    • 37849011793 scopus 로고    scopus 로고
    • Pharmacokinetic profile on lubiprostone, a selective GI chloride channel activator, after a single oral dose in multiple animal species [abstract 901]
    • Crawford DF, Perentesis GP, Engelke KJ, et al. Pharmacokinetic profile on lubiprostone, a selective GI chloride channel activator, after a single oral dose in multiple animal species [abstract 901]. Am J Gastroenterol. 2005;100(9 suppl):S330.
    • (2005) Am J Gastroenterol , vol.100 , Issue.9 SUPPL.
    • Crawford, D.F.1    Perentesis, G.P.2    Engelke, K.J.3
  • 18
    • 0037741690 scopus 로고    scopus 로고
    • Efficacy and safety of a novel compound, RU-0211, for the treatment of constipation [abstract 1511]
    • Johanson JF, Gargano MA, Patchen ML, Ueno R. Efficacy and safety of a novel compound, RU-0211, for the treatment of constipation [abstract 1511]. Gastroenterology. 2002;122:A315.
    • (2002) Gastroenterology , vol.122
    • Johanson, J.F.1    Gargano, M.A.2    Patchen, M.L.3    Ueno, R.4
  • 19
    • 34248595894 scopus 로고    scopus 로고
    • Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Aliment Pharmacol Ther. 2007;25:1351-1361.
    • Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Aliment Pharmacol Ther. 2007;25:1351-1361.
  • 20
    • 2442466372 scopus 로고    scopus 로고
    • Phase III efficacy and safety of RU-0211, a novel chloride channel activator, for the treatment of constipation [abstract]
    • Johanson JF, Gargano MA, Holland PC, et al. Phase III efficacy and safety of RU-0211, a novel chloride channel activator, for the treatment of constipation [abstract]. Gastroenterology. 2003;124:A48.
    • (2003) Gastroenterology , vol.124
    • Johanson, J.F.1    Gargano, M.A.2    Holland, P.C.3
  • 21
    • 33646770937 scopus 로고    scopus 로고
    • Initial and sustained effects of lubiprostone, a chloride channel-2 (ClC-2) activator for the treatment of constipation: Data from a 4-week phase III study [abstract 884]
    • Johanson JR, Gargano MA, Holland PC, et al. Initial and sustained effects of lubiprostone, a chloride channel-2 (ClC-2) activator for the treatment of constipation: data from a 4-week phase III study [abstract 884]. Am J Gastroenterol. 2005;100(9 suppl):S324-S325.
    • (2005) Am J Gastroenterol , vol.100 , Issue.9 SUPPL.
    • Johanson, J.R.1    Gargano, M.A.2    Holland, P.C.3
  • 22
    • 33645058986 scopus 로고    scopus 로고
    • Phase III study of lubiprostone, a chloride channel-2 (ClC-2) activator for the treatment of constipation: Safety and primary efficacy [abstract 896]
    • Johanson JF, Gargano MA, Holland PC, et al. Phase III study of lubiprostone, a chloride channel-2 (ClC-2) activator for the treatment of constipation: safety and primary efficacy [abstract 896]. Am J Gastroenterol. 2005;100(9 suppl):S328-S329.
    • (2005) Am J Gastroenterol , vol.100 , Issue.9 SUPPL.
    • Johanson, J.F.1    Gargano, M.A.2    Holland, P.C.3
  • 23
    • 33645058986 scopus 로고    scopus 로고
    • Phase III patient assessments of the effects of lubiprostone, a chloride channel-2 (ClC-2) activator, for the treatment of constipation [abstract 899]
    • Johanson JF, Gargano MA, Holland PC, et al. Phase III patient assessments of the effects of lubiprostone, a chloride channel-2 (ClC-2) activator, for the treatment of constipation [abstract 899]. Am J Gastroenterol. 2005;100(9 suppl): S329-S330.
    • (2005) Am J Gastroenterol , vol.100 , Issue.9 SUPPL.
    • Johanson, J.F.1    Gargano, M.A.2    Holland, P.C.3
  • 24
    • 33749985076 scopus 로고    scopus 로고
    • Efficacy and safety of lubiprostone for the treatment of chronic constipation in elderly vs non-elderly subjects [abstract]
    • Ueno R, Joswick TR, Wahle A, et al. Efficacy and safety of lubiprostone for the treatment of chronic constipation in elderly vs non-elderly subjects [abstract] Gastroenterology. 2006;130:A189.
    • (2006) Gastroenterology , vol.130
    • Ueno, R.1    Joswick, T.R.2    Wahle, A.3
  • 25
    • 33749985076 scopus 로고    scopus 로고
    • Efficacy and safety of lubiprostone for the treatment of chronic constipation in male vs female subjects [abstract]
    • Ueno R, Joswick TR, Wahle A, et al. Efficacy and safety of lubiprostone for the treatment of chronic constipation in male vs female subjects [abstract]. Gastroenterology. 2006;130:A322.
    • (2006) Gastroenterology , vol.130
    • Ueno, R.1    Joswick, T.R.2    Wahle, A.3
  • 26
    • 33846443895 scopus 로고    scopus 로고
    • Efficacy and safety of lubiprostone in a subgroup of constipation patients diagnosed with irritable bowel syndrome with constipation (IBS-C) [abstract]
    • Johanson J, Wahle A, Ueno R. Efficacy and safety of lubiprostone in a subgroup of constipation patients diagnosed with irritable bowel syndrome with constipation (IBS-C) [abstract]. Am J Gastroenterol. 2006;101(9 suppl):S491.
    • (2006) Am J Gastroenterol , vol.101 , Issue.9 SUPPL.
    • Johanson, J.1    Wahle, A.2    Ueno, R.3
  • 27
    • 18144425423 scopus 로고    scopus 로고
    • Phase III, randomized withdrawal study of RU-0211, a novel chloride channel activator for the treatment of constipation [abstract]
    • Johanson JF, Gargano MA, Holland PC, et al. Phase III, randomized withdrawal study of RU-0211, a novel chloride channel activator for the treatment of constipation [abstract]. Gastroenterology. 2004;128:A100.
    • (2004) Gastroenterology , vol.128
    • Johanson, J.F.1    Gargano, M.A.2    Holland, P.C.3
  • 28
    • 33645375828 scopus 로고    scopus 로고
    • Multicenter open-label study of oral lubiprostone for the treatment of chronic constipation [abstract 903]
    • Johanson JF, Gargano MA, Holland PC, et al. Multicenter open-label study of oral lubiprostone for the treatment of chronic constipation [abstract 903]. Am J Gastroenterol. 2005;100(9 suppl):S331.
    • (2005) Am J Gastroenterol , vol.100 , Issue.9 SUPPL.
    • Johanson, J.F.1    Gargano, M.A.2    Holland, P.C.3
  • 29
    • 33749996742 scopus 로고    scopus 로고
    • Long-term efficacy of lubiprostone for the treatment of chronic constipation [abstract]
    • Johanson J, Panas R, Holland PC, Ueno R. Long-term efficacy of lubiprostone for the treatment of chronic constipation [abstract]. Gastroenterology. 2006;130:A317.
    • (2006) Gastroenterology , vol.130
    • Johanson, J.1    Panas, R.2    Holland, P.C.3    Ueno, R.4
  • 30
    • 33846443895 scopus 로고    scopus 로고
    • Evaluation of safety and efficacy in a twelve-month study of lubiprostone for the treatment of chronic idiopathic constipation [abstract]
    • Ueno R, Wahle A, Panas R, et al. Evaluation of safety and efficacy in a twelve-month study of lubiprostone for the treatment of chronic idiopathic constipation [abstract]. Am J Gastroenterol. 2006;101(9 suppl):S491.
    • (2006) Am J Gastroenterol , vol.101 , Issue.9 SUPPL.
    • Ueno, R.1    Wahle, A.2    Panas, R.3
  • 31
    • 33750012942 scopus 로고    scopus 로고
    • Long-term safety and efficacy of lubiprostone for the treatment of chronic constipation in elderly subjects [abstract]
    • Ueno R, Panas R, Wahle A, et al. Long-term safety and efficacy of lubiprostone for the treatment of chronic constipation in elderly subjects [abstract]. Gastroenterology. 2006;130:A188.
    • (2006) Gastroenterology , vol.130
    • Ueno, R.1    Panas, R.2    Wahle, A.3
  • 32
    • 33748928189 scopus 로고    scopus 로고
    • A dose-ranging, double-blind, placebo-controlled study of lubiprostone in subjects with irritable bowel syndrome and constipation (c-IBS) [abstract]
    • Johanson J, Panas R, Holland PC, Ueno R. A dose-ranging, double-blind, placebo-controlled study of lubiprostone in subjects with irritable bowel syndrome and constipation (c-IBS) [abstract]. Gastroenterology. 2006;130:A25.
    • (2006) Gastroenterology , vol.130
    • Johanson, J.1    Panas, R.2    Holland, P.C.3    Ueno, R.4
  • 33
    • 34848846152 scopus 로고    scopus 로고
    • Lubiprostone significantly improves symptom relief rates in adults with irritable bowel syndrome and constipation (IBS-C): Data from two twelve-week, randomized, placebo-controlled, double-blind trials [abstract]
    • Drossman DA, Chey W, Panas R, et al. Lubiprostone significantly improves symptom relief rates in adults with irritable bowel syndrome and constipation (IBS-C): data from two twelve-week, randomized, placebo-controlled, double-blind trials [abstract]. Gastroenterology. 2007;132:2586.
    • (2007) Gastroenterology , vol.132 , pp. 2586
    • Drossman, D.A.1    Chey, W.2    Panas, R.3
  • 34
    • 37849052624 scopus 로고    scopus 로고
    • Effect of lubiprostone, a novel type-2 chloride channel (ClC-2) activator, in pregnant Rhesus monkeys [abstract T1683]
    • Presented at, May 19-24, Washington, DC
    • Engelke K, Harris S, Roerig B, Ueno R. Effect of lubiprostone, a novel type-2 chloride channel (ClC-2) activator, in pregnant Rhesus monkeys [abstract T1683]. Presented at Digestive Disease Week 2007; May 19-24, 2007; Washington, DC.
    • (2007) Digestive Disease Week 2007
    • Engelke, K.1    Harris, S.2    Roerig, B.3    Ueno, R.4
  • 35
    • 37849034280 scopus 로고    scopus 로고
    • Pooled analysis of the most frequent adverse events associated with the use of lubiprostone [abstract]
    • Ueno R, Wahle A, Rivera E. Pooled analysis of the most frequent adverse events associated with the use of lubiprostone [abstract]. Am J Gastroenterol. 2006;101(9 suppl):S489.
    • (2006) Am J Gastroenterol , vol.101 , Issue.9 SUPPL.
    • Ueno, R.1    Wahle, A.2    Rivera, E.3
  • 36
    • 37849039077 scopus 로고    scopus 로고
    • Rivera E, Wahle A, Joswick TR, Ueno R. Lubiprostone, a novel type-2 chloride channel (Clc-2) activator, does not affect serum electrolyte balance in elderly and non-elderly patients with chronic idiopathic constipation [abstract]. Gastroenterology. 2007;132:A191-A192.
    • Rivera E, Wahle A, Joswick TR, Ueno R. Lubiprostone, a novel type-2 chloride channel (Clc-2) activator, does not affect serum electrolyte balance in elderly and non-elderly patients with chronic idiopathic constipation [abstract]. Gastroenterology. 2007;132:A191-A192.
  • 37
    • 37849035566 scopus 로고    scopus 로고
    • Effect of lubiprostone, a unique agent for the treatment of chronic idiopathic constipation, on clinical electrocardiographic results [abstract]
    • Sprenger C, Copa A, Morganroth J, et al. Effect of lubiprostone, a unique agent for the treatment of chronic idiopathic constipation, on clinical electrocardiographic results [abstract]. Gastroenterology. 2007;132:A325.
    • (2007) Gastroenterology , vol.132
    • Sprenger, C.1    Copa, A.2    Morganroth, J.3
  • 38
    • 33846783486 scopus 로고    scopus 로고
    • Effects of lubiprostone on morphine-induced constipation and analgesia [abstract]
    • Ueno R, Osama H, Engelke KJ. Effects of lubiprostone on morphine-induced constipation and analgesia [abstract]. Gastroenterology. 2006;130:A373.
    • (2006) Gastroenterology , vol.130
    • Ueno, R.1    Osama, H.2    Engelke, K.J.3
  • 39
    • 37849008905 scopus 로고    scopus 로고
    • PR Newswire. FDA accepts Sucampo's sNDA for lubiprostone (8 μg) for the treatment of irritable bowel syndrome with constipation (IBS-C). Available at: www.prnewswire.com (key word: lubiprostone). Accessed September 17, 2007.
    • PR Newswire. FDA accepts Sucampo's sNDA for lubiprostone (8 μg) for the treatment of irritable bowel syndrome with constipation (IBS-C). Available at: www.prnewswire.com (key word: lubiprostone). Accessed September 17, 2007.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.